Open Source drug discovery projects for tropical diseases We develop methods for comparative docking
of small chemical compounds and their target proteins.
It was established that the addition or removal of several
small chemical groups to or from DNA could affect gene expression.
Small chemical modifications may allow similar compounds with the same effects as progesterone to be given to patients closer to the time of injury.
«Botany and health: Very
small chemical changes to dietary flavonoids cause very large effects on human immune system.»
Ecker studies epigenetic processes in plants and animals, and is a leader in studies of methylation, in which
small chemical tags called methyl groups are attached to specific sites in the genome.
While it has been understood for some time now that tRNAs are heavily decorated
with small chemical groups such as methyls (carbon atoms bound to three hydrogens), the unprecedented discovery that one of these modifications can be removed suggests that tRNA has a regulatory role in the process of protein translation through chemical changes in itself.
Long - term heroin abusers show differences
in small chemical modifications of their DNA and the histone proteins attached to it, compared to non-abusers.
Scientists at the University of York have discovered that
very small chemical changes to dietary flavonoids cause very large effects when the plant natural products are tested for their impact on the human immune system.
This is basically tweaking the molecules:
making small chemical changes to the compound in hopes of finding something that could block the growth of blood vessel cells initially in the culture dish without having toxic effects on other cell types.
Isn't Kerry proposing a strategy in which the most likely scenarios are that either Assad survives or that the factions of a post-Assad Syria fight over
somewhat smaller chemical weapons stockpiles?
Starting just before conception, Jirtle and Waterland fed a test group of mother mice a diet rich in methyl donors,
small chemical clusters that can attach to a gene and turn it off.
The researchers have as such modified microalgae genetically to
become small chemical factories with a build in power supply.
This enzyme scavenges the sugar
from small chemicals that the body sends to the gastrointestinal track for elimination.
Dr Clarkson and his team joined up with researchers Dr Andrea Brancale and Dr Andrew Westwell from the Cardiff University School of Pharmacy and Pharmaceutical Sciences, to
develop small chemical inhibitors of the Bcl3 gene.
Predictive patterns Gerszten and his colleagues measured more than 200 metabolites,
small chemicals involved in the body's metabolism, using mass spectrometry in individuals before and after exercise.
One type of epigenetic change to the genome occurs
when small chemical groups glom on to the ladder structure of DNA.
As an answer to this question, Wu and colleagues used a genetic technique to light up the places on the surface of the R2 neurons where they actively
release small chemical neurotransmitters, sending information to neighboring cells.
To encode the membrane with a smart and dynamic response to
small chemical hazards, LLNL scientists and collaborators are surface modifying these prototype carbon nanotube membranes with chemical - threat - responsive functional groups.
«We show
how small chemical changes — involving only a few atoms — lead to big changes in assembly and disease - associated aggregation,» Fawzi said.
Dr. Schang is a virologist whose research program focuses on exploring the ways biologically
active small chemicals affect viral replication.
Plastics are polymers, long, potentially complex, molecule chains crafted from an array of
smaller chemical units.
Household waste is collected separately, based on of a variety of waste streams like organic waste, paper and cardboard and
small chemical waste.
When newly hatched majors were injected with molecules that increased the number of
small chemical groups attached to their DNA's protein scaffolding, they behaved like minors.
Histone proteins can be modified
with small chemical groups, many of which are products of cellular metabolism.
He would wake up soaked,
small chemical... [Read More]
«If we find some targets that constantly change in the eye with glaucoma, then we may be able to find
some small chemicals to target those genes in the eye,» he said of these «druggable» targets.
Epigenetic effects include modification of DNA by incorporation of
small chemical groups, methyl groups.
That made researchers worry that
small chemicals — which might be just 2 % of a protein's size — would be too puny to turn on such receptors.
But when p53 levels are restored by blocking its degradation using
a small chemical compound called Nutlin - 3, the tumors are less aggressive and have fewer cancer stem cells.
«Tiny details have amazing effects: A slight change in the substrate, like the removal of
a small chemical group, is sufficient to practically stop the reaction.»
Histone proteins have long polypeptide tails that can be modified by the addition and removal of
small chemical groups.
The histones that form the barrels can be reversibly modified via the attachment of
small chemical groups, which in turn regulates how tightly the DNA can be wrapped around them and therefore how condensed the chromatin is.
We are also fortunate to have two commercial aircraft toilets on the DC - 8; on the NSF C - 130s and the NASA P - 3, we make do with a funnel for the men and
a small chemical toilet for the women.
The idea is that
small chemical tags, such as acetylation, on chromatin marking active or inactive genes would self - propagate independently of the underlying DNA sequence and direct the activity of the genome.
According to experts,
the small chemical particles inhaled from these cleaning products cause damage that is comparable to cigarette smoking.
Organic foods have minimal toxicity, thus placing
a smaller chemical burden on the body.
This is
a small chemical company that makes chemicals used for water treatment, flavor enhancers, pharmaceuticals and other purposes.
Metabolomics is an emerging field in which a very large number of
small chemicals can be analyzed from samples of body fluids and tissues.