Sentences with phrase «small clinical studies»

Small clinical studies of 2 - to 4 - week duration in type 2 diabetes (T2DM) have led to inconsistent results.

Two small clinical studies show brain changes among young football players with a history of concussion and exposure to high - impact hits.

Despite small clinical studies that have reported efficacy of the approach, the mechanism of action is poorly understood.

Those results were encouraging enough that within a few months Kaplan started a small clinical study of 11 bipolar patients who had not been able to control their illness with conventional medications.

A small clinical study of clarithromycin for the sleep disorder hypersomnia shows that the antibiotic can combat patients» subjective experience of sleepiness, but it does not seem to improve reaction time measured in a video - game - type vigilance task.

Not exact matches

Some small studies have suggested that synbiotics could provide benefits to a range of other conditions influenced by the gut microbiome as well, including obesity, diabetes, and non-alcoholic fatty liver disease, but larger - scale clinical trials focusing on each of those conditions are needed.

Both multinational and small and medium - sized enterprises are invited to apply to participate in the studies, the first stage in a groundbreaking public - private partnership — MaRS Excellence in Clinical Innovation and Technology Evaluation («EXCITE»).

Although it might be inferred that confidence in addressing the needs of breastfeeding mothers translates into better clinical management of breastfeeding issues, the number of residents in this study was too small to correlate the performance of individual residents in the clinical setting with their reported confidence level.

It has been observed by several clinical studies and surveyed by awareness groups that this product is no longer safe to be used in small babies.

Although some SIDS experts and policy - makers endorse pacifier use recommendations that are similar to those of the AAP, 272,273 concerns about possible deleterious effects of pacifier use have prevented others from making a recommendation for pacifier use as a risk reduction strategy.274 Although several observational studies275, — , 277 have found a correlation between pacifiers and reduced breastfeeding duration, the results of well - designed randomized clinical trials indicated that pacifiers do not seem to cause shortened breastfeeding duration for term and preterm infants.278, 279 The authors of 1 study reported a small deleterious effect of early pacifier introduction (2 — 5 days after birth) on exclusive breastfeeding at 1 month of age and on overall breastfeeding duration (defined as any breastfeeding), but early pacifier use did not adversely affect exclusive breastfeeding duration.

Maria Leadbeater, Clinical Nurse Specialist at Breast Cancer Care, said: «This small study provides a unique retrospective insight into the link between breast density and risk of recurrence after breast conserving surgery.

Small - scale studies have suggested that the nets do work, but there haven't been any large - scale clinical trials.

«We found that nearly one in four patients with small tumours are at risk of distant metastases and do benefit from chemotherapy,» said Dr Fatima Cardoso, senior author of the study, Co-Principal Investigator of MINDACT and Director of the Breast Unit of the Champalimaud Clinical Centre, Lisbon, Portugal.

A new clinical study at the University of Michigan Health System will test the ability of a once daily dose of doxycycline to reduce the growth of small abdominal aortic aneurysms.

Often, those smaller animals express the genetic abnormality very differently from humans, says clinical scientist and pediatric neurologist James Dowling at the University of Michigan, Ann Arbor, who studies the myopathies and their genetic causes in both children and zebrafish.

A global analysis of metabolites and small molecules in urine samples from patients with adrenal cancer has identified four biochemicals that, when measured together, can distinguish malignant from benign adrenal tumors, according to study results presented at the 2015 Annual Clinical Congress of the American College of Surgeons.

In a study that included children and young adults with relapsed or refractory cancer, incorporation of integrative clinical genomic sequencing data into clinical management was feasible, revealed potentially actionable findings in nearly half of the patients, and was associated with change in treatment and family genetics counseling for a small proportion of patients, according to a study in the September 1 issue of JAMA.

A sleep deficiency of even a small degree can disrupt our lives in a number of ways — from a setback in daily routine to bringing about or exacerbating existing chronic diseases,» said Andrew N. Carr, Ph.D., Clinical Scientist and study co-author, Procter & Gamble.

With the initial contract of $ 24.9 million over the next 18 months, Mapp Pharmaceutical will manufacture a small amount of the drug for early - stage clinical studies to demonstrate its safety and efficacy in people.

On parent - reporting measures, girls with autism seem to struggle more than boys with performing routine tasks like getting up and dressed or making small talk, even when the study group is normalized to meet similar basic clinical diagnostic criteria across sexes.

Using simple statistics, without data about published research, Ioannidis argued that the results of large, randomized clinical trials — the gold standard of human research — were likely to be wrong 15 percent of the time and smaller, less rigorous studies are likely to fare even worse.

In a small study, supported by Ohio State's Center for Clinical and Translational Science (CCTS) Davis Bremer Pilot Award, Powers identified more than 140 micro-RNAs that are present in the spinal fluid of eight patients who had an SAH followed by DCI.

The study, published in the June issue of the Journal of Clinical Sleep Medicine, reaffirms numerous small - scale studies in the United States, Western Europe and Japan, but it does so using data compiled across six middle - income nations and involving more than 30,000 subjects for a long - term project that began in 2007.

Previous studies have shown that a small molecule known as ONC201 currently in advanced cancer clinical trials, targets self - renewing colorectal cancer stem cells.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.

«We showed with this technique that we can detect very tiny tumors of just a few hundred cells,» Lu said, adding that the study pushed imaging boundaries, revealing smaller cancers than can be detected with current clinical imaging modalities.

Those encouraging findings from the small - scale pilot study formed the basis for this multi-center clinical trial led by Carley and Zee.

«Previous studies suggest that reducing heart fat is feasible through weight loss or weight management, but these studies only looked at small numbers of people and there have been no clinical trials linking cardiovascular outcomes with heart fat changes due to weight management interventions.

Investigative studies of human biology with an emphasis on disease, including small clinical trials

However, the researchers believe that the studies are too few and too small, and that new clinical trials are needed to take this research to the next level.

Dr Siddharth Banka, Clinical Senior Lecturer at the Manchester Centre for Genomic Medicine, who led the study, explained: «Our team has identified that this new syndrome is caused by a small deletion on chromosome 6 that affects the function of hypothalamus, a region of the brain that plays a number of important roles in the body.»

The study, published in the July issue of the journal Epidemiology, offers benefits over typically used randomized clinical trials, as such studies are often too small to identify rare side effects or may be performed in a group of patients who do not take other types of medications or have other conditions that could skew the drug's effect in a broader group following approval.

In a joint study, clinical pharmacologist Markus Zeitlinger and gastroenterologist Werner Dolak from MedUni Vienna showed that this combination of medication can result in inflammation in the small intestine.

The Pilot Bioproduction Facility headed by Dr. Kenneth H. Eckels, produced small batches of vaccine candidates that were used for the preclinical studies and is currently manufacturing a vaccine lot for use in initial human clinical studies.

The authors note the small size of the study necessitates future research in clinical models and in men and women, particularly those who have sarcopenia.

«Our study is small, retrospective and all of the patients were located at a single medical center, but it demonstrates that it's possible to use molecular diagnostics to identify subgroups of patients more likely to respond to a given treatment,» said co-first author John Paul Shen, MD, senior clinical fellow and postdoctoral fellow.

«This large population - based study in women with ICP found increased risks of later hepatobiliary cancer and immune - mediated diseases and a small increased risk of later cardiovascular disease,» explained principal investigator Hanns - Ulrich Marschall, MD, of Sahlgrenska Academy, Institute of Medicine, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.

As a frequent consultant to small start - up companies, Friedman works alongside clinical researchers to develop the research protocols in clinical studies.

«Lithium, long used in mental health as a highly effective mood stabiliser, has been on the radar as a potential disease modifying treatment for Alzheimer's disease with positive evidence from preclinical studies and a number of small clinical trials.

Vescor, advised by its scientific founders White and Kimmelman, whose research has shown inhibition of autophagy can dramatically impact tumor growth in pre-clinical models, will develop small molecule inhibitors of a number of protein targets at critical nodes of the autophagy cascade, perform investigational new drug (IND) enabling studies, and move these into clinical development.

Table 1: Selection, Design & Construction of HSV - based Oncolytic Viruses Table 2: Selection, Design & Construction of Adenovirus - based Oncolytic Viruses Table 3: Selection, Design & Construction of Vaccinia Virus - based Oncolytic Viruses Table 4: Selection, Design & Construction of Vesicular Stomatitis Virus - based Oncolytic Viruses Table 5: Selection, Design & Construction of Newcastle Disease Virus - based Oncolytic Viruses Table 6: Selection, Design & Construction of Various Virus - based Oncolytic Viruses Table 7: Current Company - Sponsored Clinical Trials of T - Vec Table 8: Clinical Trials of ColoAd1 Table 9: Clinical Trials with JX - 594 Table 10: Clinical Trials with GL - ONC1 Table 11: Clinical Trials of CAVATAK (CVA21) Table 12: Clinical Trials with MV - NIS Table 13: Overview of Oncolytic Viruses by Development Phase & Virus Family Table 14: Profile of Approved and Marketed Oncolytic Viruses Table 15: Pivotal Study Design of Oncolytic Viruses in Late Stage Development Based on Previous Clinical Results Table 16: Approved Indications of Immune Checkpoint Inhibitors Table 17: Active Clinical Studies of Oncolytic Viruses in Combination with Immune Checkpoint Inhibitors (ICI) Table 18: Planned Clinical Studies of Oncolytic Viruses in Combination with Immune Checkpoint Inhibitors (ICI) Table 19: Active or Planned Clinical Studies of Oncolytic Viruses in Combination with Other Anti-Cancer Therapeutics Table 20: Pattern of Transgenes in Oncolytic Viruses in Relation to Development Phase Tables 21a and 21b: Indications and Frquency and Way of Administration of Oncolytic Viruses in Active and / or Positive Completed Clinical Studies Table 22: Small and Medium Pharma & Biotech as Partner for Regional Co-Development of Oncolytic Viruses Table 23: Immuno - Oncology Portfolio of Major Pharma & Biotech with Interest in Oncolytic Viruses Table 24: Interests of Major Pharma & Biotech in Oncolytic Viruses Table 25: First Generation Oncology Virus Companies and their Sources of Technology Table 26: Second Generation Oncology Virus Companies and their Sources of Technology Table 27: Third Generation Oncology Virus Companies and their Sources of Technology Table 28: Fourth Generation Oncology Virus Companies and their Sources of Technology Table 29: Grants, Credits & Donations Table 30: Financing by Venture Capital, Private Equity and Other Private Placements Table 31: Collaboration & Licensing Agreements Table 32: Companies Listed on Stock Exchange & Offerings Table 33: Mergers & Acquisitions

Although these studies were limited to small patient numbers, given the rarity of this disease, PD - 1 pathway blockade seems to have clinical efficacy in mucosal melanoma, with a tolerable safety profile.

First of all, early clinical studies of MSCs involved small numbers of cells manufactured for a small numbers of patients.

Most published studies entailed small number of subjects; well - designed studies with larger sample sizes are needed to ascertain how this test can reduce clinical diagnostic uncertainty or impact treatment planning.

Evaluating the efficacy of repurposed small molecule inhibitors in treating filariasis using preclinical and clinical studies

A Clinical Core has capability to safely and efficiently distribute clinical studies of vaccine immunosafety for biomarker discovery from small intensive trials to large - scale studies of adult, paediatric and other popuClinical Core has capability to safely and efficiently distribute clinical studies of vaccine immunosafety for biomarker discovery from small intensive trials to large - scale studies of adult, paediatric and other popuclinical studies of vaccine immunosafety for biomarker discovery from small intensive trials to large - scale studies of adult, paediatric and other populations.

A comprehensive review on Aurora kinase: small molecule inhibitors and clinical trial studies

The Animal and Human Imaging Shared Resource enables Cancer Center investigators to execute high throughput, quantitative and noninvasive in vivo imaging studies on animal models, apply and validate MRI, optical, CT, PET, SPECT and ultrasound methods for noninvasive detection and characterization in small animals and incorporate emerging and clinical relevant quantitative MRI and PET protocols into Phase I, II and III clinical trials in a centralized, cost effective manner.

Omecamtiv mecarbil is a selective, small - molecule currently being studied in a Phase 3 clinical trial of ~ 8000 patients as a potential treatment for heart failure with reduced ejection fraction in collaboration with Amgen and in partnership with Servier.

Study designs, both large scale clinical trials as well as smaller mechanistic studies, will take into consideration and take advantage of the heterogeneity of clinical phenotypes in the study deStudy designs, both large scale clinical trials as well as smaller mechanistic studies, will take into consideration and take advantage of the heterogeneity of clinical phenotypes in the study destudy design.