Sentences with phrase «small clinical trials for»

A drug used for decades to treat high blood pressure and other conditions has shown promise in a small clinical trial for autism.

Not exact matches

As an exec at Shire (shpg), which with $ 6 billion in revenue is one of the smaller Big Pharmas, he spent months persuading leaders and commercial and supply - chain people to launch a clinical trial for the ADHD drug Vyvanse to treat binge eating.

While Yervoy brought in $ 960 million in sales in 2013 (an enormous figure for a two - year - old drug with a small patient population), the company currently has more than 35 ongoing clinical trials investigating another drug that disengages the immune system's brakes: the much - awaited nivolumab, which was also from the Medarex portfolio.

To achieve this goal, several approaches are envisaged: identifying small populations with severe disease where a medicine's benefit - risk balance could be favorable; making more use of real - world data where appropriate to support clinical trial data; and involving health technology assessment bodies early in development to increase the chance that medicines will be recommended for payment and ultimately covered by national healthcare systems.

Although some SIDS experts and policy - makers endorse pacifier use recommendations that are similar to those of the AAP, 272,273 concerns about possible deleterious effects of pacifier use have prevented others from making a recommendation for pacifier use as a risk reduction strategy.274 Although several observational studies275, — , 277 have found a correlation between pacifiers and reduced breastfeeding duration, the results of well - designed randomized clinical trials indicated that pacifiers do not seem to cause shortened breastfeeding duration for term and preterm infants.278, 279 The authors of 1 study reported a small deleterious effect of early pacifier introduction (2 — 5 days after birth) on exclusive breastfeeding at 1 month of age and on overall breastfeeding duration (defined as any breastfeeding), but early pacifier use did not adversely affect exclusive breastfeeding duration.

In the randomized clinical trial, 230 adults with fibromyalgia received one of three treatments, each of which was presented for eight weekly sessions to small groups of patients.

Most Class III devices do require clinical testing, but the clinical trials are typically smaller, much less costly, and shorter in duration than those required for pharmaceuticals.

Research groups at universities and hospitals need to meet strict safety guidelines for clinical trials but some small private clinics are offering therapies to people without research or marketing approval.

AG1295 won't work inside the body because it can't get to the marrow, but Small says his team has already identified other FLT3 inhibitors potentially useful for patients, and clinical trials are just around the corner.

This small molecule is in clinical trials against cancer and has high specificity and good pharmacological properties, which could warrant its further development as antiviral drug for treatment of pH1N1 virus infection,» Dr. Oxana Denisova says.

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

Those encouraging findings from the small - scale pilot study formed the basis for this multi-center clinical trial led by Carley and Zee.

Her research at Stanford University has contributed to the development of a small molecule peptide that is currently in Phase IIA clinical trials for AD.

In a small phase I and II clinical trial, Johns Hopkins researchers and colleagues elsewhere found that the high - fat, low - carbohydrate ketogenic diet was a safe and effective treatment option for the majority of adults experiencing a relatively rare, often fatal and always severe form of epilepsy marked by prolonged seizures that require medically induced comas to prevent them from further damaging the body and the brain.

In a small, phase I clinical trial, Johns Hopkins Kimmel Cancer Center researchers say they show for the first time that the experimental drug guadecitabine (SGI - 110) is safe in combination with the chemotherapy drug irinotecan and may overcome resistance to irinotecan in patients with metastatic colorectal cancer.

This approach, however, differs from liquid biopsies, including commercial tests, which only profile a relatively small portion of the genome in patients already diagnosed with cancer for the purpose of helping monitor the disease or detect actionable alterations that can be matched to available drugs or clinical trials.

In a small, single - center clinical trial, Chadwick Miller, M.D., M.S., and colleagues found that evaluating older, more complex patients in the observation unit with stress cardiac MRI, as opposed to usual inpatient care, reduced hospital readmissions, coronary revascularization procedures and the need for additional cardiac testing.

«Epilepsy drug discovered in fish model shows promise in small pediatric clinical trial: Research suggests zebrafish models may be efficient resource for identifying drugs for clinical use.»

There is a small clinical trial trying to test it for wet AMD.

Although these platforms can be used successfully for small - scale expansion of hMSCs, other platforms will be required to generate the quantity of cells required to support the increasing number of clinical trials utilizing hMSCs and the subsequent large - scale production.

Some research efforts are closer to clinical implementation, including developing improvements in clinical management of rare diseases and trials of small molecule therapies for inherited and mosaic genetic disorders.

«Lithium, long used in mental health as a highly effective mood stabiliser, has been on the radar as a potential disease modifying treatment for Alzheimer's disease with positive evidence from preclinical studies and a number of small clinical trials.

Table 1: Selection, Design & Construction of HSV - based Oncolytic Viruses Table 2: Selection, Design & Construction of Adenovirus - based Oncolytic Viruses Table 3: Selection, Design & Construction of Vaccinia Virus - based Oncolytic Viruses Table 4: Selection, Design & Construction of Vesicular Stomatitis Virus - based Oncolytic Viruses Table 5: Selection, Design & Construction of Newcastle Disease Virus - based Oncolytic Viruses Table 6: Selection, Design & Construction of Various Virus - based Oncolytic Viruses Table 7: Current Company - Sponsored Clinical Trials of T - Vec Table 8: Clinical Trials of ColoAd1 Table 9: Clinical Trials with JX - 594 Table 10: Clinical Trials with GL - ONC1 Table 11: Clinical Trials of CAVATAK (CVA21) Table 12: Clinical Trials with MV - NIS Table 13: Overview of Oncolytic Viruses by Development Phase & Virus Family Table 14: Profile of Approved and Marketed Oncolytic Viruses Table 15: Pivotal Study Design of Oncolytic Viruses in Late Stage Development Based on Previous Clinical Results Table 16: Approved Indications of Immune Checkpoint Inhibitors Table 17: Active Clinical Studies of Oncolytic Viruses in Combination with Immune Checkpoint Inhibitors (ICI) Table 18: Planned Clinical Studies of Oncolytic Viruses in Combination with Immune Checkpoint Inhibitors (ICI) Table 19: Active or Planned Clinical Studies of Oncolytic Viruses in Combination with Other Anti-Cancer Therapeutics Table 20: Pattern of Transgenes in Oncolytic Viruses in Relation to Development Phase Tables 21a and 21b: Indications and Frquency and Way of Administration of Oncolytic Viruses in Active and / or Positive Completed Clinical Studies Table 22: Small and Medium Pharma & Biotech as Partner for Regional Co-Development of Oncolytic Viruses Table 23: Immuno - Oncology Portfolio of Major Pharma & Biotech with Interest in Oncolytic Viruses Table 24: Interests of Major Pharma & Biotech in Oncolytic Viruses Table 25: First Generation Oncology Virus Companies and their Sources of Technology Table 26: Second Generation Oncology Virus Companies and their Sources of Technology Table 27: Third Generation Oncology Virus Companies and their Sources of Technology Table 28: Fourth Generation Oncology Virus Companies and their Sources of Technology Table 29: Grants, Credits & Donations Table 30: Financing by Venture Capital, Private Equity and Other Private Placements Table 31: Collaboration & Licensing Agreements Table 32: Companies Listed on Stock Exchange & Offerings Table 33: Mergers & Acquisitions

Small, focused clinical trials are possible for certain B - cell malignancies such as Diffuse Large B - Cell Lymphoma in which patients can be stratified based on NF - kB activation status and / or presence of mutations known to activate NF - kB.

Clinical benefits of lentiviral vectors have been observed in small trials for other diseases, including the common hematopoietic disorders

SEATTLE — An imaging agent discovered by a Washington State University researcher that homes in on prostate cancer will be developed for human clinical trials thanks to a two - year $ 2 million federal Small Business Innovation Research grant.

This small clinical trial will evaluate a treatment for improving processing speed in 20 people with MS.. This computer - based treatment has been shown to be effective in an aging population.

A Clinical Core has capability to safely and efficiently distribute clinical studies of vaccine immunosafety for biomarker discovery from small intensive trials to large - scale studies of adult, paediatric and other popuClinical Core has capability to safely and efficiently distribute clinical studies of vaccine immunosafety for biomarker discovery from small intensive trials to large - scale studies of adult, paediatric and other popuclinical studies of vaccine immunosafety for biomarker discovery from small intensive trials to large - scale studies of adult, paediatric and other populations.

A total of 13 Dream Team clinical trials are active right now, for patients with bladder cancer, kidney cancer, prostate cancer, triple - negative breast cancer, gastric cancer, pancreatic cancer, small cell and non-small cell lung cancer, sarcoma, and melanoma, and seven more trials are planned.

Rethinking the traditional drug development process for rare diseases will be critical, including trial design for small populations, real - world evidence collection, stronger patient engagement for data collection and definition of clinical end - points.

The Animal and Human Imaging Shared Resource enables Cancer Center investigators to execute high throughput, quantitative and noninvasive in vivo imaging studies on animal models, apply and validate MRI, optical, CT, PET, SPECT and ultrasound methods for noninvasive detection and characterization in small animals and incorporate emerging and clinical relevant quantitative MRI and PET protocols into Phase I, II and III clinical trials in a centralized, cost effective manner.

Omecamtiv mecarbil is a selective, small - molecule currently being studied in a Phase 3 clinical trial of ~ 8000 patients as a potential treatment for heart failure with reduced ejection fraction in collaboration with Amgen and in partnership with Servier.

Since the small victory, Catherine and her foundation have continued to push for more fecal microbiota transplant (FMT) clinical trials aimed at other digestive disorders, more research funding and more public awareness and education.

20 - 30 % of patients with acute myeloid leukemia have mutations of the FLT3 biomarker that make them eligible for several FLT3 - targeted small molecule therapies currently in late stage clinical trials.

Tobacco Regulatory Science Small Grant Program for New Investigators (R03 Clinical Trial Optional)

Reviews of clinical trials on hypnosis have concluded that the evidence of its effectiveness for smoking cessation is insufficient, but other research shows promise: The preliminary results from a small 2007 study of smokers hospitalized with cardiopulmonary diseases showed that the patients who chose to participate in a hypnotherapy session were more likely to be nonsmokers six months later than patients who chose nicotinereplacement therapy (NRT) alone.

Two other small clinical trials evaluated the effects of supplementation with 200 mg zinc sulfate (providing 45 mg zinc) for 2 years in subjects with drusen or macular degeneration.

For the most part, evidence - based guidance is drawn largely from human clinical trials, experimental studies in dogs and cats [13,14] and the collective clinical experience of small animal practitioners.

To accomplish our mission, we serve as a «one - stop - shop» for our veterinary faculty, other campus units and study sponsors by providing clinical technical expertise, administrative support and financial oversight for small and large animal clinical trials in multiple disciplines, including (but not limited to) ophthalmology, oncology, neurology, cardiology, dermatology, diagnostic imaging, dentistry, internal medicine, orthopedics and soft tissue surgery.

A clinical trial for the drug is underway in the Cardiology Service at the Wilford and Kate Bailey Small Animal Teaching Hospital.

Contact: If you are interested in determining whether your dog is eligible for the trial, please schedule an appointment for evaluation with one of the participating clinical services by calling the Small Animal Clinic at [phone] for either Soft Tissue Surgery, Dentistry and Oral Surgery, or Oncology.

Purpose: This clinical trial is being done to investigate whether small particles called nanoporhphyrins can be used to better visualize tumors during surgery and potentially to see if they will be a useful method to deliver drugs into brain tumors for treatment.

But the Schmidts also found a small silver lining — the chance to participate in a clinical trial that could improve cancer treatment for not only dogs, but their humans, too.

During his academic time he had a particular interest in high - quality research and research appraisal, enrolling in a Masters degree program in Epidemiology, being involved in veterinary clinical trials of novel drugs to treat cardiac disease, and becoming cardiology associate editor for both the Journal of Small Animal Practice and Veterinary Medicine and Science, as well as being a member of the external review board for the Journal of Veterinary Cardiology.

Clinical trials — chemotherapy parity (oral and intravenous)-- for individual, small and large group plans, employer and non-employer-based HMOs

First, the effect sizes are smaller both in absolute terms and in comparison to effect sizes reported elsewhere — for example, in the UK, the National Institute for Health and Clinical Excellence reported effects of 1.7 for waiting list versus trauma focused psychological therapies and 1.18 for other active interventions for PTSD.1 Second, there are problems with the small number of trials in key areas (for example, TAU / WL n = 5), with the combining of different outcomes from the same study in the meta - analysis and the failure to consider clinical as opposed to statistical signiClinical Excellence reported effects of 1.7 for waiting list versus trauma focused psychological therapies and 1.18 for other active interventions for PTSD.1 Second, there are problems with the small number of trials in key areas (for example, TAU / WL n = 5), with the combining of different outcomes from the same study in the meta - analysis and the failure to consider clinical as opposed to statistical signiclinical as opposed to statistical significance.