Sentences with phrase «small effects on disease»

The associated alleles were common in the studied populations and all had only small effects on disease risk [123].

Not exact matches

In diseases such as malaria and sickle cell disease, red blood cells break down, with harmful effects on the rest of the body — particularly the lining of small blood vessels.

Results: Daily ingestion of wheat - based starch hydrolysates, glucose syrups and maltodextrins, had no deleterious effect on small - bowel mucosal villous architecture or inflammation in coeliac disease patients when compared to the placebo group.

For the individual, such small associations, even if real, will have only minor effects or no effect on overall health or risk of disease.

The number of infants receiving mixed feeding was too small (table 1) to estimate precisely its effect on diarrhoeal disease, and for further analysis they were combined either with exclusive breast milk or with formula.

«We have discovered a small molecule compound that shows a profound and prolonged effect on autism - like social deficits without obvious side effects, while many currently used compounds for treating a variety of psychiatric diseases have failed to exhibit the therapeutic efficacy for this core symptom of autism,» said Zhen Yan, PhD, professor in the Department of Physiology and Biophysics in the Jacobs School of Medicine and Biomedical Sciences at UB, and senior author on the paper.

The researchers considered two possible explanations: Disease suppression might be the result of one or two additional substitutions on the same gene that buffer the harmful effect of the mutation; or suppression may be caused by numerous small substitutions throughout the genome that form an aggregate «shield.»

Dr Andersen said the study was important because, although there have been other studies looking at the effects of endurance exercise on various cardiovascular problems such as ischemic heart disease and stroke, there have been only a few, smaller studies of its effect on heart rhythm disturbances, and they have tended to look at people who are less physically active, or compared very sedentary people with those who were very active.

The process of drug discovery has been dominated in recent years by the screening of large libraries of structurally diverse small molecules for effects on target proteins associated with disease.

Since the recent discovery of tremendous biological effects of nitric oxide, other small gaseous molecules such as carbon monoxide or hydrogen sulfide have emerged to be similarly important in cell signaling, with a great impact on pathophysiology of various diseases.

It's no secret that smoking is harmful, but it's been hard to study its effects on chronic obstructive pulmonary disease (COPD), a disease that leaves sufferers short of breath thanks to inflammation of the small airways in the lung.

Yet most of the identified variants had a very small effect on risk, and they collectively explained only a fraction of disease heritability.

Neurologist and Researcher Dr. Zoe Arvanitakis was one of the scientists to take part in the study, and she commented that» Both large and small vessel diseases have effects on dementia and thinking abilities, independently of one another, and independently of the common causes of dementia such as Alzheimer's pathology and strokes.»

ApoE as a major causative factor and therapeutic target in Alzheimer's disease and other neurodegenerative disorders; small - molecule structure correctors to convert apoE4 to apoE3 and reverse the detrimental effects of apoE4 on mitochondria and the cytoskeleton; small - molecule protease inhibitors to block the formation of toxic fragments of apoE4; Plasma lipoprotein metabolism regulation involving apoE and apoB; cholesterol homeostasis modulation by lipoprotein receptors controlling lipoprotein clearance by the liver; Plasma HDL cholesterol (HDL - C) metabolism in the progression of atherosclerosis; the genetic epidemiology of the metabolic syndrome and low HDL - C levels established by the Turkish Heart Study.

Most of these variants are benign (having no effect on health), but a small number of variants are pathogenic (related to disease).

«The duration of the trial was too small to notice any substantial effects on coronary heart disease or death,» he said.

I am not saying that some oils can be healthy, but maybe curtains oils can have a smaller effect on cardiovascular disease, but maybe a more neutral one?

Even injured animals, those with medical conditions, and those who are pregnant or lactating should be vaccinated on entry, because vaccination will likely be effective, and the small risk of adverse effects is outweighed by the high risk of disease exposure and infection in the shelter.

The therapeutic dotential of dietary precursor modulation by a fish - oil - supplemented diet (n - 3 fatty acids), such as eicosapentaenoic acid (C20: 5,n - 3) and docosahexaenoic acid (C22: 6,n - 3) in the therapy of ulcerative colitis has been shown to result in a 35 % to 50 % decrease in neutrophil production of LTB4.28 Significant improvement in symptoms and histologic appearance of the rectal mucosa has been observed in several small series of patients with Crohn's disease and ulcerative colitis given fish oil at 3 to 4 g daily for 2 to 6 months in uncontrolled studies.29 However, a larger, randomized, double - blind trial comprising 96 patients with ulcerative colitis failed to reveal any benefit in remission maintenance or treatment of relapse on 4.5 g of eicosapentaenoic acid daily, despite a significant reduction in LTB4 synthesis by blood peripheral polymorphonuclear cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fatty acids.

This is an interesting finding as it suggests that CM / SM may be a multifactorial disease dependent on the cumulative effects of a small CCF and large cerebellum.