The team screened
a small molecule compound library and identify a drug, which they call CLP257.
Not exact matches
The technology is allowing basic scientists and
small companies to generate impressive
libraries of
molecules, on a scale once reserved for big pharma, and select from them the most useful
compounds.
In this study, the researchers screened a
library of 200,000
small molecule compounds to identify potential inhibitors of Ebola virus RNA synthesis.
Scientists for decades have applied similar «phenotypic selection» methods to
libraries of standard
small -
molecule compounds.
In one case, the researchers screened a
small -
molecule compound library and identified
compounds that bind tightly to NUCB1, an otherwise little - known protein that showed strong interactions with the arachidonoyl probes.
Such projects involve developing and optimizing assays for automation, screening a large
compound library, and characterizing each
small -
molecule probe.
The MSC is a core facility providing the use of high throughput screening technology (HTS), as well as expertise and reagents, necessary for the screening of the
library of
small molecules for biologically active
compounds in a variety of readout systems.
The course gives a broad introduction to high throughput screening (HTS) that is technique used to identify biologically active
small organic
molecules through screening of
compound libraries with the help of robust test systems and advanced instrumentation.
The emerging field of DNA - encoded chemical
library allows us to perform selection of
small molecule compounds.
Then the wells were exposed to a
library of
small -
molecule compounds.