Sentences with phrase «small molecule drug candidates»

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In their ACS Central Science study, Disney and his colleagues used DNA sequencing to evaluate thousands of small molecules as potential drug candidates.

Using computer simulations to predict which drug candidates offer the greatest potential has thus far not been very reliable, because both small drug - like molecules and the amino acids of proteins vary so much in their chemistry.

RNAi therapeutics, peptides and small molecules, drug candidate progression to clinical development, R&D management.

Determining whether a disease - related protein can react strongly with a small - molecule probe or candidate drug — in a way that alters its function — is often an essential first step in drug development.

The drug candidate is a synthetic, small molecule inhibitor of indoleamine 2,3 - dioxygenase (IDO1) that also inhibits IDO1 in the tumor micro-environment to trigger immune - modulation.

An emerging strategy in early drug discovery entails using fragments, i.e. molecules smaller than conventional drug candidates, as starting points for design of novel therapeutic compounds.

The Unit's scientific mission covers the design, synthesis, molecular modeling, as well as biophysical, biochemical and cellular studies of small - molecule probes and drug candidates targeting nucleic acids or proteins involved in cancer.

Dr. King points out that a number of oral drug candidates inhibit PKC - delta and that it may be possible to suppress PKC - delta production with microRNAs (small RNA molecules that help to regulate protein generation).

Figure 2: Comparing the patent landscapes for induced pluripotent stem cell (top) and a small - molecule drug candidate (MK - 1775, bottom) highlights need for intellectual property consideration in cell therapy DST — search and analysis conducted in Thomson Innovation and Thomson Data Analyzer (TDA) software from Thomson Reuters; themescape maps produced using TDA.

Phenotypic screening of small molecule libraries using iPSC - based models to identify novel drug candidates and disease mechanisms.