Hopefully, this knowledge, coupled to utility of the mAGES system, will spark the search for
small molecule drug combinations which can safely and efficiently modulate the involved pathways and promote astrocyte to NSC conversion.
Not exact matches
The good news is that we found a
small molecule drug being tested in cancers that activates apoptosis and we decided to test it in
combination therapy.»
Many researchers are trying to find ways around this; one possibility is identifying
small drug - like
molecules that could replace the reprogramming - factor / virus delivery
combination.
Because SLC6A14 is essential for tumour growth yet dispensable for normal development and tissue maintenance,
small molecules that block amino acid import through this transporter could be effective and selective anti-cancer agents, particularly as components of rational
drug combinations.
The project that is farthest along involves the discovery of
small molecules for use in
combination with
drugs of last resort for extensively
drug - resistant tuberculosis infections.
Eventually, the team hopes that a
combination of
small,
drug - like
molecules could be developed to replace the cocktail, offering a safer and easier method of delivery.