Discovering novel
small molecule drug leads depends on the ability to efficiently search chemical diversity.
Not exact matches
For instance, a team
led by Sheng Ding of the Scripps Research Institute in La Jolla is screening for
small -
molecule drugs that can substitute for the reprogramming genes.
«The next step is to identify antibodies and
small -
molecule drugs that can successfully target Helios or genes in the Helios pathway,» says the study's
lead author, Hye - Jung Kim, PhD, of Dana - Farber.
Basic research on cancer mechanisms has
led to over 40 targeted cancer therapies currently on the market, which take the form of monoclonal antibodies,
small molecule drugs, and immunotherapies.
Thus far, the smallpox grid has generated «44 really interesting
leads —
small molecules that could potentially be turned into a
drug,» says Hubbard.
The consolidation of these efforts in an independent initiative will allow faculty from the CMI to
lead a focused investigation in
small molecule drug discovery for multiple therapeutic applications.
He served as Laboratory Director at biotech company, Prosetta Corporation,
leading several
small molecule drug discovery programs focused on viruses of interest to the United States Department of Defense.
Tags for this Online Resume: high throughput screening, cell culture, data, assay development,
drug discovery, label - free, Biacore, Perkin Elmer,
small molecule, hit - to -
lead, ion channel, GPCR, enzyme, enzymatic, assay