Sentences with phrase «small molecule drug which»

Not exact matches

Shukla and colleagues discovered that a small drug molecule called BX795, which is sold to labs for use in experiments, helped clear HSV - 1 infection in cultured human corneal cells, in donated human corneas, and in the corneas of mice infected with HSV - 1.

The pH during one of the reactions was a bit too low, causing the drug to extrude a single small molecule of propionic acid, which transformed it from a powerful narcotic into a poison that laid waste to the brain's dopamine receptors.

Many drugs today are «small molecule» drugs in which molecules of active ingredients easily dissolve and diffuse because they are small enough to cross key membranes in the body.

Using computer simulations to predict which drug candidates offer the greatest potential has thus far not been very reliable, because both small drug - like molecules and the amino acids of proteins vary so much in their chemistry.

«The Holy Grail of small molecule research is to know which protein the drug directly binds to.

The researchers created a new gel, based on small molecules which self - assemble into nanofibers which could interact with a variety of anti-inflammatory, painkiller drugs, including iburofen and naproxen.

This small molecule is in clinical trials against cancer and has high specificity and good pharmacological properties, which could warrant its further development as antiviral drug for treatment of pH1N1 virus infection,» Dr. Oxana Denisova says.

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

Most do their job well, but they come with a major drawback: «Most drugs in use right now are small molecules, which are very tiny and nonspecific.

The larvae are also permeable to small molecules, which will allow scientists to batch - test different drug compounds against the infection relatively quickly and easily, said co-author David Tobin, Ph.D., assistant professor in molecular genetics and microbiology and immunology at Duke.

Basic research on cancer mechanisms has led to over 40 targeted cancer therapies currently on the market, which take the form of monoclonal antibodies, small molecule drugs, and immunotherapies.

The new method gives scientists more power not only to find new antibody - based therapies, but also to discover the biological pathways through which they work — pathways that may turn out to be more easily and cheaply targeted by small - molecule drugs.

This will give way to the development of a drug to be used in gene therapy against neurodegenerative diseases based on small molecules which enhance the expression of the gene and / or the use of fragments of the Klotho protein itself.

The basic problem the team faced with these and other vaccines they've developed is that the opioid drugs are small molecules, which are not recognized by the immune system.

A typical small - molecule drug derives its activity from such functional groups, which are bound to a relatively simple backbone structure consisting chiefly of carbon atoms.

PEG - PLA nanoparticles have an inner core that is ideally suited to carry hydrophobic small - molecule drugs, which include many chemotherapy drugs.

One effective approach is to deliver drugs made from small molecules of ribonucleic acid, or RNA, which are used to inhibit gene expression.

Interestingly, the dominant model for the mechanism by which a small molecule like a drug fits into the active site of a disease - promoting enzyme and modulates its activity is that of a «lock and key».

They collected gene expression data from six genetically diverse breast cancer cell lines, which were each exposed to 109 small - molecule drugs at multiple dosages and time points.

In another experiment, a more direct test of druggability, the researchers used a library of small molecules — broadly representing potential drug molecules — to see which could compete with the probe in binding covalently to reactive lysines on human proteins.

Hopefully, this knowledge, coupled to utility of the mAGES system, will spark the search for small molecule drug combinations which can safely and efficiently modulate the involved pathways and promote astrocyte to NSC conversion.

(That's different from manufacturing a small - molecule generic, which will have the exact chemical structure of the brand - name drug.)

TLC's first project, which is also a pilot project of the TRND program, focuses on repurposing an existing small molecule drug, auranofin, initially approved to treat rheumatoid arthritis in the mid-1980s.

Not a light read, this tome is bursting with information about monoclonal antibodies, from the history of how these therapies were first developed to new approaches such as conjugate therapy, which combines antibodies with small - molecule drugs.

Orders of magnitude more sensitive than conventional Raman microscopy, they allow mapping of 3D distributions of small molecules, such as metabolites and drugs, as well as tumor identification in tissues, which open many exciting new possibilities for biology and medicine.

Then for postdoctoral research I moved to Yale University, where I worked in a lab that looked at all kinds of different disease areas using the approaches of a field called chemical biology, which is using small molecules — chemicals — to probe biological systems in the hopes of developing compounds that could be new drugs.

Our goal is to study the molecular mechanisms by which the IL - 1R - TLRs mediate signaling, with the long - term aim of developing more effective anti-inflammatory small - molecule drugs.

The team screened a small molecule compound library and identify a drug, which they call CLP257.

As the drug enters your system, it breaks down itself into small molecules that is enough to pass through your body's cell mainly because as mentioned earlier, every cell in our body have receptors for steroids called androgen receptor which is where the steroid molecules bind.