Sentences with phrase «small molecule inhibitor of»

EOS200271 is a synthetic, small molecule inhibitor of indoleamine 2,3 - dioxygenase (IDO1), an immunosuppressive enzyme that is induced in a wide range of cancers.

This product candidate is a uniquely senolytic small molecule inhibitor of the MDM2 / p53 protein interaction.

IDO1 Inhibitor (EOS200271): Synthetic, small molecule inhibitor of indoleamine 2,3 - dioxygenase (IDO1) to trigger immune - modulation in the tumor micro-environment.

The drug candidate is a synthetic, small molecule inhibitor of indoleamine 2,3 - dioxygenase (IDO1) that also inhibits IDO1 in the tumor micro-environment to trigger immune - modulation.

A Small Molecule Inhibitor of Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits Repair of Interstrand DNA Crosslink, enhances DNA Double - strand Break, and sensitizes Cancer Cells to Cisplatin.

Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis.

We discovered a potent small molecule inhibitor of furin which has proven useful both in bacterial diseases where furin activation is critical to toxin activation as well as in cancer pathogenesis.

A small molecule inhibitor of monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin.

iTeos is now developing EOS200271 which is a synthetic, small molecule inhibitor of indoleamine 2,3 - dioxygenase (IDO1), which has demonstrated the same anti-tumour activity in multiple preclinical tumour models in combination with immune checkpoint inhibitors as competitors, but also has demonstrated superior brain penetration.

This lab, in collaboration with the lab of Ruben Shaw at the Salk Institute, recently identified SBI - 0206965, the first potent and selective small molecule inhibitor of ULK1, a serine / threonine kinase that is a critical regulator of autophagy.

The authors also found that a novel small molecule inhibitor of the salvage pathway enzyme deoxycytidine kinase blocked leukemia growth in mice in combination with thymidine (to inhibit the de novo pathway).

Our team is currently developing methods that can be used to screen small molecule inhibitors of EDD1 and also looking into how the regulation of TIP60 levels can be translated into therapeutic advances for the treatment of viral - mediated cancers such as cervical cancer.

Dr. Levitsky: Other sections under the Oncology Discovery and Translation Area (DTA) focus on anti-angiogenesis, small molecule inhibitors of the p53 pathway, apoptosis, signal transduction, and the tumor microenvironment.

Whilst the function of MRP4 has been advanced by MRP4 - / - mice and RNAi, until now the absence of specific small molecule inhibitors of MRP4 has been a major constraint.

Small Molecule Inhibitors of CXCR4 Bikash Debnath, Shili Xu, Fedora Grande, Antonio Garofalo, Nouri Neamati Theranostics 2013; 3 (1): 47 - 75.

Identification of small molecule inhibitors of Cisplatin - induced hair cell death: results of a 10,000 compound screen in the zebrafish lateral line.

«We are presently testing a number of biological and small molecule inhibitors of Notch3,» he said.

She remained in Sheffield to complete a PhD and short post-doc in the lab of Professor Beining Chen, primarily working to screen and characterise small molecule inhibitors of anthrax toxins as part of a collaboration with the Health Protection Agency at Porton Down.

Finally, we show that addition of small molecule inhibitors of eIF2α dephosphorylation to muscle stem cell cultures permits their ex vivo expansion and engraftment into a preclinical mouse model of Duchenne muscular dystrophy.

Vescor, advised by its scientific founders White and Kimmelman, whose research has shown inhibition of autophagy can dramatically impact tumor growth in pre-clinical models, will develop small molecule inhibitors of a number of protein targets at critical nodes of the autophagy cascade, perform investigational new drug (IND) enabling studies, and move these into clinical development.

He went on to a postdoctoral position with Dr. Iwao Ojima evaluating anti-tubercular compound series that inhibit the cell division protein FtsZ and screening computationally designed small molecule inhibitors of Botulinum neurotoxin.

Not exact matches

«Our research and development team has made tremendous progress with our portfolio of novel, small molecule Naᵥ1.7 inhibitors for the treatment of acute and chronic pain,» said Stan Abel, President and Chief Executive Officer of SiteOne Therapeutics.

The new research, published recently as two separate studies in ACS Central Science and the Journal of the American Chemical Society, demonstrates that a new class of drugs called small molecule RNA inhibitors can successfully target and kill specific types of cancer.

Using small - molecule inhibitors to eliminate the activity of the proteins produced by the bird - specific, median signaling zone in chicken embryos, the researchers were able to induce the ancestral molecular activity and the ancestral anatomy.

In this study, the researchers screened a library of 200,000 small molecule compounds to identify potential inhibitors of Ebola virus RNA synthesis.

A panel of small molecules that inhibit Zika virus infection, including one that stands out as a potent inhibitor of Zika viral entry into relevant human cell types, was discovered by researchers from the Perelman School of Medicine at the University of Pennsylvania.

Therefore, a novel therapeutic approach in inflammatory breast cancer could involve a combination of conventional chemotherapy with small - molecule inhibitors of the Cdk2 cell cycle kinase.

The newly crafted molecule is non-toxic, simple to produce, and cost - effective compared to the production of alternate treatment strategies, such as antibodies and small molecule inhibitors.

To do so, they treated melanoma cells with a panel of small molecules and identified JNJ - 7706621 (JNJ) as the best inhibitor of cyclinB1 / cdk1.

Those features present significant challenges in drug discovery, and in fact, DNA - binding proteins traditionally have been considered to be beyond the reach of even small molecule inhibitors.

Coincidentally, co-author Lawrence Shapiro, PhD, at Columbia, was building a crystal structure of cadherin - 11 and is now working with Byers and Brenner to show how the molecule binds to Celebrex and other small molecule drug cadherin - 11 inhibitors.

By using pharmacological small molecule inhibitors as well as neutrophils from genetically modified mouse strains the team could identify essential receptor and signaling pathways involved in the nicotine - mediated activation of neutrophils.

turned into 10 years of systematic research to identify the enzyme PLK4 as a promising therapeutic target and develop a small molecule inhibitor to block it,» says Dr. Mak, Director of The Campbell Family Institute for Breast Cancer Research at the Princess Margaret Cancer Centre, University Health Network.

«If we could design a small molecule inhibitor that would look like heme - iron but would actually clog up a key metabolic pathway in bacteria, we may be able to get around the problem of antibiotic resistance,» suggests Dr. Mason, who adds that he and Dr. Justice plan to use the new five - year NIH grant to further studies of just such an inhibitor.

Small molecule MYC inhibitor conjugated to integrin - targeted nanoparticles extends survival in a mouse model of disseminated multiple myeloma.

Founded in 2015, STORM Therapeutics is a British - based developer of small - molecule inhibitors of RNA - modifying enzymes for the treatment of cancer.

Scanning electron micrograph of the coronary microvasculature of a mouse that has been treated with a small molecule tyrosine kinase inhibitor of platelet - derived growth factor receptor beta.

Hu and his collaborator Juan R. Del Valle at the University of South Florida are developing novel small molecule inhibitors against IRE - 1 to combat cancers associated with high numbers of MDSCs.

Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY - 320 and BAY - 524.

Application of high - throughput screening to identify a novel αIIb - specific small - molecule inhibitor of αIIbβ3 - mediated platelet interaction with fibrinogen.

BMS - 754807, a Small - Molecule Inhibitor of Insulin - like Growth Factor - 1 Receptor / Insulin Receptor, Enhances Gemcitabine Response in Pancreatic Cancer.

Identification of novel small - molecule inhibitors of glioblastoma cell growth and invasion by high - throughput screening.

Functional regulation of cystic fibrosis transmembrane conductance regulator - containing macromolecular complexes: a small - molecule inhibitor approach.

That produced a class of drugs known as angiotensin - converting enzyme, or ACE, inhibitors that hit the market in the early 1980s, and during the next 25 years or so, there followed a string of blockbuster small - molecule drugs that included such familiar names as Lipitor, Zantac and Prozac.

MPC - 6827: a small - molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps.

We have used a variety of cell models to test toxicity, cell penetration, and efficacy of furin inhibitors, and have identified small molecule inhibitors selective for cell surface furin action as well as inhibitors which also work intracellularly.

Navire Pharma is a new company aimed at developing novel small - molecule inhibitors of a tyrosine - protein phosphatase called SHP2 (also known as PTPN11) for genetically - driven and treatment - resistant cancer.

The University of Texas MD Anderson Cancer Center and BridgeBio Pharma today announced the launch of Navire Pharma, a biopharmaceutical company aimed at developing novel small - molecule inhibitors of a tyrosine - protein phosphatase called SHP2 for genetically driven and treatment - resistant cancer.

Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma

Practically speaking, this knowledge of how the toxin recognizes the double receptor could lead to a rational basis for designing small - molecule inhibitors to this recognition step,» he said.