Sentences with phrase «small molecule inhibitors including»

Not exact matches

A panel of small molecules that inhibit Zika virus infection, including one that stands out as a potent inhibitor of Zika viral entry into relevant human cell types, was discovered by researchers from the Perelman School of Medicine at the University of Pennsylvania.

That produced a class of drugs known as angiotensin - converting enzyme, or ACE, inhibitors that hit the market in the early 1980s, and during the next 25 years or so, there followed a string of blockbuster small - molecule drugs that included such familiar names as Lipitor, Zantac and Prozac.

The team is taking several approaches to inhibit HIF - 1 activity, including RNA interference, dominant negative constructs, and small molecule inhibitors.

AG490 is a small molecule inhibitor that blocks several tyrosine kinases including Jak2 (Gazit et al., 1991); Ruxolitinib is a small molecule inhibitor that specifically suppresses Jak kinases (Quintas - Cardama et al., 2010).

Particular expertise in fields relating to antibody therapeutics and formats, nucleic acid therapeutics, various small molecule therapeutics including covalent inhibitors, and vaccines.