Such a similarity makes TNFΔARE a unique model of a complex human pathology appropriate for the simoultaneous testing of novel therapeutics and
small molecule inhibitors on two different pathologies.
Not exact matches
The company's therapeutic candidates are highly selective sodium ion channel 1.7 (Naᵥ1.7)
inhibitors based
on naturally occurring
small molecules.
Dr. Levitsky: Other sections under the Oncology Discovery and Translation Area (DTA) focus
on anti-angiogenesis,
small molecule inhibitors of the p53 pathway, apoptosis, signal transduction, and the tumor microenvironment.
Our group has 3 major goals: Develop novel therapeutic approaches based
on centrosomal clustering To further develop our first prototype
inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput
small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate
small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus
on multiple myeloma
His thesis work focused
on developing novel
small molecule inhibitors against protein targets such as survivin and STAT3 that are essential for progression and survival of cancer.
He went
on to a postdoctoral position with Dr. Iwao Ojima evaluating anti-tubercular compound series that inhibit the cell division protein FtsZ and screening computationally designed
small molecule inhibitors of Botulinum neurotoxin.
A comprehensive review
on Aurora kinase:
small molecule inhibitors and clinical trial studies
ApoE as a major causative factor and therapeutic target in Alzheimer's disease and other neurodegenerative disorders;
small -
molecule structure correctors to convert apoE4 to apoE3 and reverse the detrimental effects of apoE4
on mitochondria and the cytoskeleton;
small -
molecule protease
inhibitors to block the formation of toxic fragments of apoE4; Plasma lipoprotein metabolism regulation involving apoE and apoB; cholesterol homeostasis modulation by lipoprotein receptors controlling lipoprotein clearance by the liver; Plasma HDL cholesterol (HDL - C) metabolism in the progression of atherosclerosis; the genetic epidemiology of the metabolic syndrome and low HDL - C levels established by the Turkish Heart Study.