Sentences with phrase «small molecule libraries using»

Phenotypic screening of small molecule libraries using iPSC - based models to identify novel drug candidates and disease mechanisms.

Encoding method for OBOC small molecule libraries using a biphasic approach for ladder - synthesis of coding tags.

Not exact matches

Still eager to make an MIS - like contraceptive for all women that is cheap and easy to use, perhaps as a pill, the researchers are searching libraries of small molecules to find one that mimics the action of MIS.

They identified AM404 as a potential antiviral agent by screening the National Institutes of Health Clinical Collection, a library of small molecules that have been used clinically in humans, using a high - throughput screening system.

The MSC is a core facility providing the use of high throughput screening technology (HTS), as well as expertise and reagents, necessary for the screening of the library of small molecules for biologically active compounds in a variety of readout systems.

In another experiment, a more direct test of druggability, the researchers used a library of small molecules — broadly representing potential drug molecules — to see which could compete with the probe in binding covalently to reactive lysines on human proteins.

The course gives a broad introduction to high throughput screening (HTS) that is technique used to identify biologically active small organic molecules through screening of compound libraries with the help of robust test systems and advanced instrumentation.

Once the Vanderbilt small molecule library has been screened for potential modulators of the Y4 receptor, I will use the results to design efficient and accurate descriptors that can be used with artificial neural networks to predict activity at the Y4 receptor based on a small molecule's structural properties.

Using this information, we will then take advantage of recent advances in the quantification of assembly to screen candidate small - molecule libraries for enhanced activity in assembly acceleration, inhibition, and misdirection.

The investigations are frequently combined with large scale perturbation methods, including gene - based (RNAi, miss - expression of wild type and mutant genes) and chemical approaches using small molecule libraries.