Sentences with phrase «small molecules»

An ideal model for the evaluation of small molecule inhibitors in two disease models simultaneously.

His primary interests are novel small molecule drugs, next generation vaccines, and cell therapies.

Moreover, protein - protein interactions can be directly targeted with small molecules.

By differentiating cells over and over under various conditions, his group intends to use them to screen for small molecules that might interfere with the disease process.

Those features present significant challenges in drug discovery, and in fact, DNA - binding proteins traditionally have been considered to be beyond the reach of even small molecule inhibitors.

She also investigated the mode of action for such small molecules in controlling bacterial behaviors.

Researchers focused on two species of bacteria that break up dietary fibers from food into small molecules called short - chain fatty acids.

The scientists report that the next step is to identify this cell - to cell signal and attempt to block it using small molecules.

Food and drink must be changed into smaller molecules of nutrients before the blood absorbs them and carries them to cells throughout the body.

This is believed to be the first study to focus on small molecules associated with this disease.

The smart gel could provide structural rigidity in organs such as the lungs, and can contain small molecules like water or drugs to be transported in the body and released.

Free radicals are unstable small molecules which are generated by an oxygen environment.

The platform serves as a potential way to help researchers quickly discover new carriers for a broad range of treatments, from small molecules to gene therapies.

However, it's not easy to design small molecules against transcription factors — by their nature they don't have a molecular structure we can easily design blocking chemicals against.

We're trying to make small molecules right now.

Small molecules targeting the zinc - binding enzyme could block the toxin's effects.

First, the fungi accumulate sugars and other small molecules in their cells, which, in turn, brings in more water.

Protein is a compound comprised of chains of smaller molecules known as amino acids, and it's the basic building block of your body.

She began by studying how small molecules recognize DNA.

«When we discover a new small molecule, we have the advantage of knowing that it works in vivo,» he says.

We're convinced, based on this result, that we can put together a platform that would enable on - demand assembly of complex small molecules.

Plants are capable of making tens of thousands of different small molecules — an average leaf for example, produces around 20,000.

But few labs use it to track interactions between small molecules in membranes, he said.

This barrier works to protect the brain from toxins by allowing only small molecules to pass through.

The GI tract is where we break down food into much smaller molecules, that are then absorbed and used by the body to make energy, repair tissue, and clear toxins.

Certain small molecules in particular have affinity for particular types of cells.

Unfortunately, not every gene product can be targeted with conventional small molecule inhibitors.

The acidity of urine — as well as the presence of small molecules related to diet — may influence how well bacteria can grow in the urinary tract, a new study shows.

These large molecule drugs differ from traditional pharmaceuticals in that they are usually injected, while small molecule pharmaceuticals are taken in tablet form.

However, while small molecule drugs can cause unwanted side effects because they are easily absorbed in the body, protein drugs can have the opposite problem: they can be too big.

The team discovered that adding small molecules made from amino acids in the outer coordination sphere increased the speed without requiring additional energy to drive the catalyst.

These methods are useful in studying protein - protein interactions and identify and optimize small molecule drugs to inhibit these interactions.

PROFESSIONAL SUMMARY * An experienced scientist with excellent managerial and training skills in small molecule analysis.

But the mechanisms involved in most diseases are inside cells, and reaching those requires small molecules, at least for now.

Works with start - up company to navigate a complex small molecule patent landscape and develop an exclusivity proposition attractive to large pharmaceutical partners.

Their analysis identified a series of possible small molecules that make economic sense and could be made by converting captured CO2.

We are working on how to screen for and isolate small molecules to impact that pathway and test them in animal models for a number of different diseases.

Final breakdown of remaining small molecules of food occurs in the lower small intestine.

The bacteria break up large molecules that the host can not digest, and the host in turn absorbs many of the resulting small molecules for energy and nutrients.

The human body builds all the different kind of proteins it needs for these tasks by putting smaller molecules called «amino acids» into chains.

The automated process has the potential to greatly speed up and enable new drug development and other technologies that rely on small molecules.

Small molecule drugs were used to inhibit the function of a cellular pathway associated with protein synthesis.

Second is the lack of understanding of the detailed molecular mechanisms of regeneration and thus the lack of identified proteins that can be targeted with small molecules.

However, a different solution is required for small molecules because they lack a common functional group that can be employed for attachment to the solid phase.

The newly crafted molecule is non-toxic, simple to produce, and cost - effective compared to the production of alternate treatment strategies, such as antibodies and small molecule inhibitors.

To use fructose for energy, the body needs to convert it into another type of simple sugar called glucose or into other smaller molecules.

During digestion, they make vitamins that are vital for life, send signals to the immune system, and make small molecules that can help your brain work.