Sentences with phrase «small noncoding»

One of the gene's molecular targets, for example, is a microRNA (a small noncoding RNA molecule) called let7, which in turn regulates hundreds of other genes, so the effects of Lin28a can set off a complex array of regulatory interactions.

The patterns of a type of molecule that influences epigenetic inheritance, called small noncoding RNA, differed between the two groups, as did methylation patterns in the sperm DNA in the two groups, the team reports today in Cell Metabolism.

In a study exploring the molecules controlling osteoclast differentiation in the cancer setting, Ell et al. have identified miRNAs (microRNAs are small noncoding RNAs that regulate gene expression) whose levels were consistently down - or up - regulated in differentiating osteoclasts.

Small noncoding microRNAs (miRNAs) have been found in such abundance that they have been christened the «dark matter» of the cell, a view reinforced by an analysis of the small RNAs found in Arabidopsis (pp. 1567 and 1525).

Not exact matches

Many are probably simply the consequence of 6 million years of genetic drift, with little effect on body or behavior, whereas other small changes — perhaps in regulatory, noncoding sequences — may have dramatic consequences.

Extensive research has already examined the function of microRNAs, a category of small evolutionarily conserved noncoding RNAs about 22 to 24 nucleotides in length that target protein - coding genes in a sequence - specific manner.

That DNA includes slightly less than 21,000 protein - coding genes (some researchers once estimated we had more than 100,000 such genes); «genes» for 8800 small RNA molecules and 9600 long noncoding RNA molecules, each of which is at least 200 bases long; and 11,224 stretches of DNA that are classified as pseudogenes, «dead» genes now known to really be active in some cell types or individuals.

«Molecular defenses spearheaded by small RNAs called piRNAs (my favorite noncoding RNAs) can keep transposons from jumping,» Saey says.

One way to control expression, he explains, is through microRNA, small pieces of noncoding genetic material that control whether a gene's protein is generated from the DNA blueprints inside cell nuclei.

3) This finding also reveals the possibility that maternal small - noncoding RNAs participate in fetal epigenetic regulation during pregnancy.

MiRNAs are small endogenous noncoding RNAs which negatively regulate gene expression.

These robust regulators of genetic programs comprise a novel class of small, noncoding RNAs that regulate gene expression by repressing protein translation.

Using genome - scale RNA interference (RNAi) screening and other high - throughput methodologies to uncover the functions of noncoding RNAs in the mammalian system, the McManus Lab has generated and characterized many small (micro) RNA conditional knockout mice.