Sentences with phrase «small number of proteins»

In contrast to other types of glycosylation, O - linked modifications with glucose and fucose affect only a small number of proteins, including the essential signaling receptor Notch.

The fact that introduction of a small number of proteins into adult human cells could produce cells that are equivalent to embryo stem cells takes us into an entirely new era of stem cell biology.

«Our work suggests that the apparent complexity of protein networks is deceiving, and that a circuit involving a small number of proteins might control each cellular function,» said senior author Shohei Koide, PhD, professor of biochemistry & molecular biophysics at the University of Chicago.

Not exact matches

Even before treatment, cancer patients in the study had a small number of infection - and tumor - fighting T cells that target these unusual proteins, the researchers found.

The researchers found that aggressive LUAD cells expressed a number of proteins that allow them to persist outside the lungs in small numbers.

«The number of protein functions that are currently targeted by drugs is incredibly small compared to the total number of protein interactions that could be targeted for therapeutic benefit,» says Geoffrey Wahl, a professor in Salk's Gene Expression Laboratory.

When newly hatched majors were injected with molecules that increased the number of small chemical groups attached to their DNA's protein scaffolding, they behaved like minors.

A 1 - millisecond simulation of the folded protein BPTI reveals a small number of structurally distinct conformational states whose reversible interconversion is slower than local relaxations within those states by a factor of more than 1000.

Nestler: It's, to a first level of approximation, it's simple and straightforward, that there are a set number of modifications that could be made to the DNA itself or to the proteins that bind to DNA and control its structure, and activity and that those small number of modifications either turn a gene on or off.

The number of experimentally determined protein structures is quite small at the moment, but this will change markedly over the next 5 years.

In the study, researchers used the blood of seven people who survived Ebola Bundibugyo virus infection during the 2007 outbreak in Uganda to isolate a large number of B cells that produce antibodies, which are the small protein molecules capable of inactivating the virus.

The branch uniting the fungi and animals is well - supported based on a number of molecular phylogenetic datasets, including the nuclear small subunit ribosomal RNA gene (Wainwright et al., 1993; Bruns et al. 1993), unique and shared sequence insertions in proteins such as elongation factor 1α (Baldauf and Palmer, 1993), entire mitochondrial genomes (Lang et al., 2002), and concatenated protein - coding genes (Steenkamp et al., 2006).

Vescor, advised by its scientific founders White and Kimmelman, whose research has shown inhibition of autophagy can dramatically impact tumor growth in pre-clinical models, will develop small molecule inhibitors of a number of protein targets at critical nodes of the autophagy cascade, perform investigational new drug (IND) enabling studies, and move these into clinical development.

By use of purified proteins, a small number of components are sufficient for the assembly of filopodia - like bundles: WASP - coated beads, actin, Arp2 / 3 complex, and fascin.

Dr. King points out that a number of oral drug candidates inhibit PKC - delta and that it may be possible to suppress PKC - delta production with microRNAs (small RNA molecules that help to regulate protein generation).

A number of different strategies are being pursued, including small - molecule drugs and antisense therapies, all with the same goal in mind: to therapeutically boost the levels of full - length SMN protein.

Using this network as a feature calculator, we train standard classifiers that assign proteins to previously unseen compartments after observing only a small number of training examples.

That's just a small fraction of the number of possible combinations available when cells make proteins.

This approach also compensates for any theoretical over-representation of proteins in pooled samples by a single or small number of individuals.

(Of course high protein / low carb foods will have little or no glucose response, so when you divide a moderate insulin response number by a very small glucose response, you get a large number.)

As per my p.s. — I suspect the majority of deaths are in the over 65s — where higher protein intake is associated with lower mortality and the smaller number of deaths in the 50 - 65 group may explain some of the large confidence intervals and relative risks.

Piperine also interferes with inflammatory signaling mechanisms and inhibits pro-inflammatory cytokines, which are small proteins secreted by some cells and linked with a number of degenerative diseases.

There may have also been some very small number of human studies that also showed a negative effect of soy, but then again — those were done with isolated soy protein, not traditional soy foods like: edamame, tofu, tempeh, and soy milk.

Protein in those diets is of higher quality and furnished in smaller amounts based on the results of studies published a number of years ago.

CANIDAE is made with a very small number of ingredients — it's a limited ingredient diet, high - protein, grain free, premium dog food.

A smaller number of allergies may be caused by food (usually the protein source) and inhalant (things they breathe in that are in the air).