Sentences with phrase «small numbers of drug»

James J. Collins, a biologist at Boston University, has found that small numbers of drug - resistant bacteria help their vulnerable counterparts survive antibiotic onslaughts, even at a cost to themselves.

Not exact matches

And much of the reason its creators felt confident enough to invest all that time, money, and effort — given the small number of patients who might eventually use the medicine — can be traced to the Orphan Drug Act, a 1983 federal law that gave those who develop meds for uncommon diseases longer periods of marketing exclusivity and other financial incentives.

The three BW authors (Benjamin Elgin, Doni Bloomfield, and Caroline Chen) take us inside the aggressive — and, at times, even combative — sales practices that helped turn a drug that treats a relatively small number of people into a blockbuster.

However, it's far simpler to do consistent, smaller price hikes on drugs used by a far greater number of people in order to make up for revenue gaps.

If it works, it could be used in a far greater number of patients than Sarepta's drug, which is approved for a relatively small slice of the DMD patient pool.

Ionis only has a small handful of Food and Drug Administration (FDA)- approved therapies, but it has a clinical - stage portfolio that's 25 experimental therapies deep, and spanning a number of indications.

Breastfeeding is contraindicated in infants with classic galactosemia (galactose 1 - phosphate uridyltransferase deficiency) 103; mothers who have active untreated tuberculosis disease or are human T - cell lymphotropic virus type I — or II — positive104, 105; mothers who are receiving diagnostic or therapeutic radioactive isotopes or have had exposure to radioactive materials (for as long as there is radioactivity in the milk) 106 — 108; mothers who are receiving antimetabolites or chemotherapeutic agents or a small number of other medications until they clear the milk109, 110; mothers who are using drugs of abuse («street drugs»); and mothers who have herpes simplex lesions on a breast (infant may feed from other breast if clear of lesions).

The sponsors want to reduce the number of people who face criminal prosecution over small amounts of the drug.

In 2014, Christiano and other CUMC researchers identified the immune cells responsible for destroying hair follicles in people with alopecia areata and tested an FDA - approved drug that led to complete hair regrowth in a small number of patients.

When you get to cancers like breast, prostate and kidney, which have smaller numbers of mutations, the drugs aren't quite as effective.

«The number of protein functions that are currently targeted by drugs is incredibly small compared to the total number of protein interactions that could be targeted for therapeutic benefit,» says Geoffrey Wahl, a professor in Salk's Gene Expression Laboratory.

The actual numbers are small: Nine of 1591 participants who took Tamiflu were admitted to the hospital, and 22 of 1302 those not taking the drug ended up there.

Cell transplantation as a treatment for diabetes is still essentially experimental, uses cells from cadavers, requires the use of powerful immunosuppressive drugs, and has been available to only a very small number of patients.

Small amounts of the silvery grey metal are used to speed up or «catalyze» a number of key industrial processes, including those that make drugs, detergents and nitrogen fertilizer, and they even play a major role breaking down toxic pollutants in the catalytic converters of our cars.

Now, in a government - funded study for which Johns Hopkins investigators recruited a small number of otherwise healthy regular cocaine users through advertisements and word of mouth, results point to «impatience» as a clear barrier to condom use in those who are sexually aroused because of the drug.

Overall psychiatric drug prescription patterns in children and adolescents Children in the youngest group accounted for the smallest number (0.8 percent) of prescriptions for any psychiatric drug.

In this way, the effect of vaccines or drugs (for example) can be tested: the more effective the active ingredient is, the smaller the number of cells that are destroyed by the viruses and the lower the measured resistance change will be.

A small number of these mutations have been found previously in other cancers, and drugs have been developed to target these mutations,» said lead author Raphael Bueno, MD, chief of the Division of Thoracic Surgery at BWH and co-director of the BWH Lung Center.

Since its dangers were revealed, the drug has been banned for veterinary use in India, Nepal, Pakistan, and Bangladesh, and vulture numbers have shown small signs of rebounding.

Although a small number of repurposed and new drugs have recently become available to treat drug - resistant TB (including bedaquiline, delamanid, and linezolid), the authors warn that without accurate diagnostic tests to deliver individually targeted treatments, clear prescription guidelines on appropriate use and improved control efforts to prevent transmission, optimal dosing and administration, and well - functioning health care systems, the effectiveness of the drugs could be rapidly lost.

Now, a study in the journal Brain describes what could be considered a direct «aquarium - to - bedside» approach, taking a drug discovered in a genetic zebrafish model of epilepsy and testing it, with promising results, in a small number of children with the disease.

Lung cancer treatment is an evolving field of science, currently there are several pathways under investigation as a possible treatment target.1 - 3 Targeted treatment is currently considered to be more efficient compared to the non-specific cytotoxic drugs, however; the small number of patients identified with mutations, limit the application of these drugs.

Vescor, advised by its scientific founders White and Kimmelman, whose research has shown inhibition of autophagy can dramatically impact tumor growth in pre-clinical models, will develop small molecule inhibitors of a number of protein targets at critical nodes of the autophagy cascade, perform investigational new drug (IND) enabling studies, and move these into clinical development.

Often the numbers are too small to obtain the meaningful statistics required to seek approval of a new drug.

A phase 1 study is one in which the primary goal of the study is to understand whether the drug is safe in a small number of volunteers.

Dr. King points out that a number of oral drug candidates inhibit PKC - delta and that it may be possible to suppress PKC - delta production with microRNAs (small RNA molecules that help to regulate protein generation).

Scientists looked at tumour samples and found that the drug penetrates the core of the tumour as well as the surrounding areas which contain smaller numbers of cancerous cells.

A number of different strategies are being pursued, including small - molecule drugs and antisense therapies, all with the same goal in mind: to therapeutically boost the levels of full - length SMN protein.

But if you want to build a lean an powerful body this diet will be a perfect fit.When you think about it — only certain people have the genetics to build an elite level physique (not to mention that only a small number of people will decide to take the amounts of drugs the pros are using).

Candida normally lives in small, harmless numbers in your vagina, 4 but medications such as antibiotics can lower the probiotics (the good bacteria) in your vagina, causing yeast to spread.5 Corticosteroids, a type of drug used to treat symptoms of various diseases by lowering your immune system, may also cause yeast to grow.

Grapefruits have an a number of compounds in them that inhibit the drug - metabolizing enzyme isoform CYP3A4 predominately in the small intestine.

Intravenous drug use was thought to be prevalent only in the North East, however, during the NACP III phase, it was realised that smaller numbers were found in the other peripheral parts of the country.

A small proportion of animals must take medication for life, and another small number, unfortunately, die of Valley Fever in spite of drug treatment.

Drugs are tested by the people who manufacture them, in poorly designed trials, on hopelessly small numbers of weird, unrepresentative patients, and analysed using techniques which are flawed by design, in such a way that they exaggerate the benefits of treatments.