Sentences with phrase «small study trials»

Not exact matches

Some small studies have suggested that synbiotics could provide benefits to a range of other conditions influenced by the gut microbiome as well, including obesity, diabetes, and non-alcoholic fatty liver disease, but larger - scale clinical trials focusing on each of those conditions are needed.

The results, which mirror those of similar, small - scale studies of the illegal drug in recent years, come as MDMA is about to enter larger, Phase 3 trials this summer.

Although Lu - PSMA - 617 put up good numbers in its small single - arm study, it still needs to outperform a physician's choice of approved treatments in a much larger global trial.

Improved postharvest practices: A recent research study undertaken by WFLO with funding by the Bill & Melinda Gates Foundation provides an great assortment of data on the results of 12 past projects, postharvest losses % for 26 crops, a description of the value chain for 30 crops in 4 countries (Rwanda, Benin, Ghana and India) and 21 field trials of postharvest technologies suitable for helping small farmers reduce losses and improve their incomes.

The sample size was small, and the researchers stated that the research findings indicate the need for a randomised control trial (RCT) as RCT's are widely recognised as the best study design.

Studies of the Nurse Family Partnership model followed children to 6 years and found significant program effects on language and cognitive functioning as well as fewer behaviour problems in a randomized controlled trial study.24 In addition, more recent evaluations of Healthy Families America have shown small, but favourable effects on young children's development.25, 26

Although some SIDS experts and policy - makers endorse pacifier use recommendations that are similar to those of the AAP, 272,273 concerns about possible deleterious effects of pacifier use have prevented others from making a recommendation for pacifier use as a risk reduction strategy.274 Although several observational studies275, — , 277 have found a correlation between pacifiers and reduced breastfeeding duration, the results of well - designed randomized clinical trials indicated that pacifiers do not seem to cause shortened breastfeeding duration for term and preterm infants.278, 279 The authors of 1 study reported a small deleterious effect of early pacifier introduction (2 — 5 days after birth) on exclusive breastfeeding at 1 month of age and on overall breastfeeding duration (defined as any breastfeeding), but early pacifier use did not adversely affect exclusive breastfeeding duration.

In the many responses to Gov. Cuomo's efforts to introduce formal and public teacher evaluation, teachers, union leaders and educational leaders have offered little but delaying tactics, such as more study is needed or how about conducting small trials.

Small - scale studies have suggested that the nets do work, but there haven't been any large - scale clinical trials.

The HYPO - RT - PC trial, a randomized multi-institutional phase III trial in Scandinavia, was designed to assess outcomes from highly accelerated extreme hypofractionation, which is delivered in smaller number of high doses — seven fractions of 6.1 Gy each in this study.

We believe that photophobia is one of the elements which may increase the risk of people suffering from panic attacks, but this is a small study, so it needs to be confirmed by a longer - term follow - up trial.

The actual disparity in number of cases between the two groups was small, with 129 lung cancers in all, and the trial wasn't set up to study that disease.

«This is a really very small trial and the results should not be over-interpreted,» says Tony Wyss - Coray, a neurologist at Stanford University in California who led the study.

In 2011, Science's editors will be watching a smaller detector at the Large Hadron Collider called LHCb, which will study B mesons in great detail; new techniques that should lead to the discovery of many more genes contributing to adaptation; an ignited fusion burn at the National Ignition Facility; broadly neutralizing antibodies, which are capable of disabling a wide range of viral variants; the first plug - in hybrid electric cars whose batteries are charged from a wall socket go on the market; and the results of the first phase III trial of a malaria vaccine.

Small studies have been limited to single academic centers or carefully selected randomized trial participants, and results have not been replicated through subsequent studies.

Using simple statistics, without data about published research, Ioannidis argued that the results of large, randomized clinical trials — the gold standard of human research — were likely to be wrong 15 percent of the time and smaller, less rigorous studies are likely to fare even worse.

Previous studies have shown that a small molecule known as ONC201 currently in advanced cancer clinical trials, targets self - renewing colorectal cancer stem cells.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.

Those encouraging findings from the small - scale pilot study formed the basis for this multi-center clinical trial led by Carley and Zee.

«Previous studies suggest that reducing heart fat is feasible through weight loss or weight management, but these studies only looked at small numbers of people and there have been no clinical trials linking cardiovascular outcomes with heart fat changes due to weight management interventions.

Investigative studies of human biology with an emphasis on disease, including small clinical trials

However, the researchers believe that the studies are too few and too small, and that new clinical trials are needed to take this research to the next level.

But to convince funding agencies that such trials are warranted, Schernhammer says, existing data from smaller studies first need to be pooled and analyzed.

The study, published in the July issue of the journal Epidemiology, offers benefits over typically used randomized clinical trials, as such studies are often too small to identify rare side effects or may be performed in a group of patients who do not take other types of medications or have other conditions that could skew the drug's effect in a broader group following approval.

This finding augments limited trial and smaller observational study results.

The study was the first randomized - controlled trial to examine the potential benefits of the low fat diet on the management of MS.. The study found no significant differences between the two groups in brain lesions detected on MRI brain scans or on other measures of MS.. But while the number of trial participants was relatively small, study leaders believe the significantly improved fatigue symptoms merited further and larger studies of the diet.

Five years ago, the small community that studies dengue began discussing challenge trials, which made some people nervous, says Anna Durbin of Johns Hopkins Bloomberg School of Public Health in Baltimore.

In a few weeks, meeting participants learned, enough data may be available from small phase I trials of a vaccine jointly made by the U.S. National Institute of Allergy and Infectious Diseases and GlaxoSmithKline (GSK) that began in September to launch efficacy studies.

Our study was small and lasted for six months so further trials need to be carried out to develop these results.

The eagerly awaited results from the world's first large - scale trial of a malaria vaccine are in, and they confirm what other, smaller studies had shown: The vaccine, called RTS, S, offers partial protection, cutting episodes of malaria in babies and toddlers in half.

A new study by researchers at Rice University and institutions in Israel showed patients in a small trial experienced remarkable improvement after two months of treatment.

«Lithium, long used in mental health as a highly effective mood stabiliser, has been on the radar as a potential disease modifying treatment for Alzheimer's disease with positive evidence from preclinical studies and a number of small clinical trials.

Table 1: Selection, Design & Construction of HSV - based Oncolytic Viruses Table 2: Selection, Design & Construction of Adenovirus - based Oncolytic Viruses Table 3: Selection, Design & Construction of Vaccinia Virus - based Oncolytic Viruses Table 4: Selection, Design & Construction of Vesicular Stomatitis Virus - based Oncolytic Viruses Table 5: Selection, Design & Construction of Newcastle Disease Virus - based Oncolytic Viruses Table 6: Selection, Design & Construction of Various Virus - based Oncolytic Viruses Table 7: Current Company - Sponsored Clinical Trials of T - Vec Table 8: Clinical Trials of ColoAd1 Table 9: Clinical Trials with JX - 594 Table 10: Clinical Trials with GL - ONC1 Table 11: Clinical Trials of CAVATAK (CVA21) Table 12: Clinical Trials with MV - NIS Table 13: Overview of Oncolytic Viruses by Development Phase & Virus Family Table 14: Profile of Approved and Marketed Oncolytic Viruses Table 15: Pivotal Study Design of Oncolytic Viruses in Late Stage Development Based on Previous Clinical Results Table 16: Approved Indications of Immune Checkpoint Inhibitors Table 17: Active Clinical Studies of Oncolytic Viruses in Combination with Immune Checkpoint Inhibitors (ICI) Table 18: Planned Clinical Studies of Oncolytic Viruses in Combination with Immune Checkpoint Inhibitors (ICI) Table 19: Active or Planned Clinical Studies of Oncolytic Viruses in Combination with Other Anti-Cancer Therapeutics Table 20: Pattern of Transgenes in Oncolytic Viruses in Relation to Development Phase Tables 21a and 21b: Indications and Frquency and Way of Administration of Oncolytic Viruses in Active and / or Positive Completed Clinical Studies Table 22: Small and Medium Pharma & Biotech as Partner for Regional Co-Development of Oncolytic Viruses Table 23: Immuno - Oncology Portfolio of Major Pharma & Biotech with Interest in Oncolytic Viruses Table 24: Interests of Major Pharma & Biotech in Oncolytic Viruses Table 25: First Generation Oncology Virus Companies and their Sources of Technology Table 26: Second Generation Oncology Virus Companies and their Sources of Technology Table 27: Third Generation Oncology Virus Companies and their Sources of Technology Table 28: Fourth Generation Oncology Virus Companies and their Sources of Technology Table 29: Grants, Credits & Donations Table 30: Financing by Venture Capital, Private Equity and Other Private Placements Table 31: Collaboration & Licensing Agreements Table 32: Companies Listed on Stock Exchange & Offerings Table 33: Mergers & Acquisitions

In addition to the small sample size and the fact that the trial was not designed or intended as an efficacy study, one important caveat is that because the trial was not investigator - blinded, it is likely that at least some bias was introduced into the assessments, particularly on the more subjective ones such as the IGA and some components of the MDS - UPDRS II and III subscales.

Only the smaller, earlier part of the trial, which studied mating effectiveness has been published.

A Clinical Core has capability to safely and efficiently distribute clinical studies of vaccine immunosafety for biomarker discovery from small intensive trials to large - scale studies of adult, paediatric and other populations.

A comprehensive review on Aurora kinase: small molecule inhibitors and clinical trial studies

The Animal and Human Imaging Shared Resource enables Cancer Center investigators to execute high throughput, quantitative and noninvasive in vivo imaging studies on animal models, apply and validate MRI, optical, CT, PET, SPECT and ultrasound methods for noninvasive detection and characterization in small animals and incorporate emerging and clinical relevant quantitative MRI and PET protocols into Phase I, II and III clinical trials in a centralized, cost effective manner.

Omecamtiv mecarbil is a selective, small - molecule currently being studied in a Phase 3 clinical trial of ~ 8000 patients as a potential treatment for heart failure with reduced ejection fraction in collaboration with Amgen and in partnership with Servier.

Study designs, both large scale clinical trials as well as smaller mechanistic studies, will take into consideration and take advantage of the heterogeneity of clinical phenotypes in the study deStudy designs, both large scale clinical trials as well as smaller mechanistic studies, will take into consideration and take advantage of the heterogeneity of clinical phenotypes in the study destudy design.

Phase 2b trials are larger than phase 2 (sometimes involving thousands of participants), but smaller than a phase 3 study.

Establishment of a collaboration with the European Lung Cancer Working Party which led to a phase II study on patients with refractory or relapsing small cell lung cancer (clinical trial # 1081 - http://www.elcwp.org/).

«Although it is known that statins do increase the risk of diabetes, the best available evidence about the size of this excess risk comes from randomised trials, which have suggested a much smaller risk than was found in this study.

Reviews of clinical trials on hypnosis have concluded that the evidence of its effectiveness for smoking cessation is insufficient, but other research shows promise: The preliminary results from a small 2007 study of smokers hospitalized with cardiopulmonary diseases showed that the patients who chose to participate in a hypnotherapy session were more likely to be nonsmokers six months later than patients who chose nicotinereplacement therapy (NRT) alone.

People in the study only had brain scans at the end of the trial, which means the researchers couldn't say whether their brains had gotten smaller over time.

Apple cider vinegar has been shown to increase insulin sensitivity in several studies, including a small but impressive trial in women with PCOS.

A number of small, controlled trials and case studies have tested the impact of yoga for those with spinal cord disease (myelopathy), traumatic brain injury, Guillain - Barre syndrome, amyotrophic lateral sclerosis (ALS), peripheral and diabetic neuropathies, adrenomyeloneuropathy, neurocardiogenic syncope, and other neurological anomalies.

The study, recently conducted at the Washington School of Medicine in St. Louis, is one of several university trials revealing that a small amount of beet juice is all it takes to beef up your exercise performance and endurance.

Initial studies looking at fasting a few days before chemotherapy in mice and dogs yielded positive outcomes, spurring small trials in humans.

A Dive Into the Research Some studies, including a small 2016 cohort trial and a 2014 mouse model, only found benefit after 48 to 72 hours of fasting.