Not exact matches
COLD SPRING HARBOR, N.Y. — When breast cancer spreads, it moves in gangs of ready - to - rumble
tumor cells, a
small genetic study
suggests.
A multicenter team of researchers reports that a full genomic analysis of
tumor samples from a
small number of people who died of pancreatic cancer
suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.
However, about 10 percent of them are common across multiple cancers,
suggesting that a relatively
small number of therapies targeting these core dependencies might each hold promise for combatting several
tumors.
Together, these results
suggested that EMT contributes to the establishment of a
small cell subpopulation in malignant
tumors; this population is then capable of driving the regeneration of the
tumor, even when the bulk
tumor cell mass is destroyed by therapeutic regimens.
When they blocked IKK2 activity in the mice with lung cancer, the mice had
smaller tumors and lived longer,
suggesting that the enzyme is necessary for NF - KB to stimulate
tumor growth.
The technique could also be applied after chemotherapy, the authors
suggest, in cases where the drugs had eliminated most the
smaller cancer, leaving only a few larger
tumors behind.
Because of
small sample size, the changes in
tumor - initiating cell number were not significant (P > 0.05), but these data are supportive of the in vitro findings and
suggest that hypoxia may have a positive effect on the
tumor - initiating cell population in ER - α — positive breast cancers and a negative effect in ER - α — negative
tumors.
Preliminary evidence from the
small clinical trial, led by William Gillanders, MD, also
suggests that the vaccine primed the patients» immune systems to attack
tumor cells and helped slow the cancer's progression.
This early onset
suggested to Al that the number of predisposing events in these pediatric
tumors must be quite
small.
THURSDAY, May 3, 2018 (HealthDay News)-- Much of the debate over when to start having mammograms has focused on lives saved, but new research
suggests that early screening might also translate into
smaller tumors and less aggressive breast cancer treatments.