Sentences with phrase «small tumour»

In contrast, no Slc6a14 − / − female with PyMT transgene developed tumours at 3 months of age; however, at 4 months of age, small tumour nodules became detectable (Figure 2B), indicating a marked delay in mammary tumour development in PyMT - Tg mice as a consequence of Slc6a14 deletion.

Radiation techniques were subsequently developed for use after surgery to control small tumour growths.

Chemotherapy (drug treatment) was later developed to destroy small tumour growths that were not treatable by other methods.

But 24 % of small tumours had an aggressive biology, which shows that not all small tumours are the same.»

«We found that nearly one in four patients with small tumours are at risk of distant metastases and do benefit from chemotherapy,» said Dr Fatima Cardoso, senior author of the study, Co-Principal Investigator of MINDACT and Director of the Breast Unit of the Champalimaud Clinical Centre, Lisbon, Portugal.

«We're so fixated on «the smaller the tumour gets, the better», but what one doesn't think about is what one has left behind,» Swanton says.

Mice that received higher doses of the drug developed smaller tumours.

«If we can image missiles 15 000 miles away in distant skies and with the Hubble telescope can see craters on Mars, we should be able to develop better tools to image small tumours in women's breasts that are right in front of us,» says Susan Blumenthal, assistant surgeon general.

However, currently available probes that use this technology fail to maximize their specificity for tumours because of strong off - target signals, and thus, have limited ability to detect small tumours in a short timespan after systemic injection.

Cancer: treatment to kill small tumours (ablation techniques), deliver chemotherapy to larger tumours (transcatheter chemo - embolization), and provide symptomatic relief for bleeding and blockages of vessels and tubes caused by cancer.

The chemo had destroyed the smaller tumours, but the testicular cancer still needed addressing surgically.

Not exact matches

The suggestion is that a small number of such cells within tumours may be the precursors to the other cancer cells in those tumours.

Approximately one year after successful treatment with cytotoxic chemotherapy and radiotherapy, patients with advanced Small Cell Lung Cancer (SCLC), which primarily affects heavy smokers, generally relapse with recurrence of tumours that are resistant to further chemotherapy.

All tumours in the study were small — less than 1 cm — and the lymph nodes were free of cancer (node negative), which in principle should be a signal of good prognosis.

«Small node negative tumours can be very aggressive, even if they are classified as clinical low risk,» said de Azambuja.

«However, as antibodies are relatively large, they were not able to penetrate tumour tissue well; small molecules should be able to accomplish this better,» explains Scheuermann.

Lois Crandell, the president of Genetronics, says the procedure is painless and can eradicate tumours with doses of toxic drugs 400 times smaller than would be needed if the drugs were injected into the bloodstream.

We can not make robust conclusions because the subgroup of patients with negative EGFR was very small, but the hypothesis generated here is that those tumours do not respond well to necitumumab.»

This means that the tumour becomes smaller as cell proliferation decreases.

At present, radiologists find it difficult to spot tumours smaller than 5 millimetres across, he says.

Results from bowel cancer - prone mice given the smaller dose showed a 50 per cent reduction in tumour size while the high dose showed a 25 per cent reduction.

«Females do not find a mating partner within the small isolated populations any more,» explains Petra Kretzschmar, scientist at the Leibniz Institute for Zoo and Wildlife Research (IZW), «the long non-reproductive periods lead to the development of reproductive tract tumours.»

That's the new picture emerging from recent studies, which suggest that a small number of stem - cell - like cells within tumours give rise to all the rest of the cancerous cells.

An early sign that this might be the case came from a small clinical trial testing a new drug that has been developed without a particular tumour type in mind.

iTeos is now developing EOS200271 which is a synthetic, small molecule inhibitor of indoleamine 2,3 - dioxygenase (IDO1), which has demonstrated the same anti-tumour activity in multiple preclinical tumour models in combination with immune checkpoint inhibitors as competitors, but also has demonstrated superior brain penetration.

Notably, the higher density of smaller diameter blood vessels in the tumour experiments resulted in enhanced tumour growth.

They find that 7.3 % of bladder, 9.8 % of colon and 14.8 % of head and neck, and 5.6 % of rectal cancers contain the presence of viral RNA, implying that virsuses may have a role in a small fraction of these tumours.

In both early stage non-small cell lung cancer and limited stage small cell lung cancer, we found evidence of a significant association between continued smoking and recurrence of the primary tumour; in limited stage small cell lung cancer, we found also evidence of a substantial elevation in the incidence of a second primary tumour.

Because SLC6A14 is essential for tumour growth yet dispensable for normal development and tissue maintenance, small molecules that block amino acid import through this transporter could be effective and selective anti-cancer agents, particularly as components of rational drug combinations.

Scientists looked at tumour samples and found that the drug penetrates the core of the tumour as well as the surrounding areas which contain smaller numbers of cancerous cells.

Many in vivo processes, including morphogenesis or tumour maturation, involve small populations of cells within a spatially restricted region.

MELGEN groups have shown that mutation screening, gene expression (using the Illumina cDNA - mediated Annealing, Selection, extension, and Ligation (DASL) Assay) platform and state of the art next generation sequencing can be applied successfully to small formalin fixed paraffin embedded (FFPE) tumours.

The first step is to understand how a small fraction of the tumour cells often escape therapy while becoming more malignant.

The effect of keratinocyte growth factor on tumour growth and small intestinal mucositis after chemotherapy in the rat with breast cancer

Most pituitary tumours responsible for Cushing's disease are small and symptoms include increased drinking and urination, increased appetite, a pot - bellied appearance, and changes to the skin.

They often start off as crusty irritated sores then progress to small bleedingsores or lumps and ultimately end up as large invasive tumours.

I can not think of an immediate link between the tumour on the lip and the vomiting; I see that you are already giving famotidine (Pepcid AC) and I guess you may be feeding smaller meals more often, if not you should be.

Mike Kohn, DVM: «In response to this [vaccine] violation, there have been increased autoimmune diseases (allergies being one component), epilepsy, neoplasia [tumours], as well as behavioural problems in small animals.»

This may occur before surgery, if a small sample of dog tumour is collected.

A biopsy may also occur after cancer surgery, if dog tumours are small and do not show signs of spreading.

Developed based on the mutations found in individual tumours, they may take the form of monoclonal antibodies, small molecular entities or immunotherapies.