Sentences with phrase «smaller oligomers»

Not exact matches

At the same time, researchers have found that much smaller protein clusters called oligomers — made of only a few copies of these proteins — can be highly toxic to motor neuron - like cells grown in the lab and thus are more likely to be the chief causes of brain - cell death in these diseases.

While these compounds did not reduce the amount of protein aggregates, they were found to reduce the protein's toxicity and to increase the stability of amyloid fibrils — a finding that lends further evidence to the theory that smaller assemblies of amyloid - beta known as oligomers, and not the fibrils themselves, are the toxic agents responsible for Alzheimer's symptoms.

Research by Finch's team in the mid -»90s also led to a startling discovery in Alzheimer's research: In 1998, working with neuroscientists at Northwestern University in Evanston, Illinois, the group reported that amyloid — the insoluble protein that piles up in the Alzheimer's - afflicted brain — is also highly neurotoxic when it clusters into small but soluble oligomers, dubbed ADDLs.

To recycle the skin, the device is soaked into recycling solution, making the polymers degrade into oligomers (polymers with polymerization degree usually below 10) and monomers (small molecules that can be joined together into polymers) that are soluble in ethanol.

We are interested in the role of secretory chaperones in the biochemistry and cell biology of the neuron and have shown that two small secretory chaperones can block the formation of both Abeta oligomers and fibrils in vitro and neurootoxic aggregates in cell culture models.

Small poisonous Aβ assemblies, called oligomers, bind strongly to vulnerable neurons in the brain, but in the presence of collagen VI, this binding was blocked.