Sentences with phrase «smaller symptom reductions»

Not exact matches

Fish oil supplements have been investigated as a treatment for adults with schizophrenia, but so far results have been mixed — four trials found no benefit while another four found a small reduction in symptoms.

The therapeutic dotential of dietary precursor modulation by a fish - oil - supplemented diet (n - 3 fatty acids), such as eicosapentaenoic acid (C20: 5,n - 3) and docosahexaenoic acid (C22: 6,n - 3) in the therapy of ulcerative colitis has been shown to result in a 35 % to 50 % decrease in neutrophil production of LTB4.28 Significant improvement in symptoms and histologic appearance of the rectal mucosa has been observed in several small series of patients with Crohn's disease and ulcerative colitis given fish oil at 3 to 4 g daily for 2 to 6 months in uncontrolled studies.29 However, a larger, randomized, double - blind trial comprising 96 patients with ulcerative colitis failed to reveal any benefit in remission maintenance or treatment of relapse on 4.5 g of eicosapentaenoic acid daily, despite a significant reduction in LTB4 synthesis by blood peripheral polymorphonuclear cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fatty acids.

A Cochrane Review25 of the effects of psychological treatments for people with dementia found that these treatments may contribute to a reduction in depressive symptoms, however evidence comes mostly from small - scale studies, with heterogeneous treatments.25 A recent systematic review of behavioural activation (BA) interventions for older people found that these are associated with a reduction in depressive symptoms in older people without dementia living in the community.26 The review also highlighted that most studies so far including people with dementia do not use well - defined interventions.

Reviews of cognitive behaviour therapy in schizophrenia indicate that evaluations are mainly case studies or uncontrolled trials.3 — 5 Four controlled trials have suggested that cognitive behavioural interventions can result in a reduction of psychotic and associated symptoms that are resistant to medication in chronic schizophrenia, 6 — 9 and a single trial has shown reduction of symptoms in acute schizophrenia.10 Although these trials are small and all suffer methodological limitations, particularly a lack of blind assessment, they represent encouraging evidence that cognitive behavioural interventions can have considerable benefits in reducing persistent hallucinations and delusions.

Limitations include small sample size, issues with the randomization of participants that resulted in differences between the groups at baseline, reliance on self - reported measures as reduction in symptoms were significant for adolescent reports but not for parent report, and generalizability due to the primarily female participant gender.

Further, there was a significant reduction of the parental inattention and hyperactivity / impulsivity symptoms on the ARS, with small effect sizes (ES =.36 and.48 respectively).