Sentences with phrase «smallest number of mutations»

We want to introduce the smallest number of mutations necessary to recreate the passenger pigeon's ecology.

Our job now is to figure out how to make immunotherapy effective against those tumors with small numbers of mutations.

When you get to cancers like breast, prostate and kidney, which have smaller numbers of mutations, the drugs aren't quite as effective.

And judging from the small number of mutations it had accumulated, it came from there only about a thousand years ago.

A small number of these mutations have been found previously in other cancers, and drugs have been developed to target these mutations,» said lead author Raphael Bueno, MD, chief of the Division of Thoracic Surgery at BWH and co-director of the BWH Lung Center.

Not exact matches

But in March, Lichun Tang of China's Beijing Proteome Research Center and colleagues reported using CRISPR / Cas9 to correct disease - causing mutations in a small number of viable human embryos.

(Previously, scientists had used CRISPR / Cas9 to repair mutations that affect smaller numbers of people with Duchenne, and in cell types that weren't necessarily clinically relevant.)

If a bacterial population can become antibiotic - resistant even when only a small number of individuals have the appropriate genetic mutations, doctors who collect and analyze small bacterial specimens from patients may underestimate just how resistant the infection is as a whole, Collins notes.

Following the study of several hundred patients, there remained a small number in whom only one mutation could be found in MMACHC.

Recent years have seen extensive research on the genetics of prostate cancer, with over a hundred mutations identified, however most of these are only present in a small number of men.

The team also found that the flightless cormorants have an abnormally high number of genetic mutations affecting cilia — small, hair - like structures that protrude from cells and regulate everything from normal development to reproduction.

Genetic factors are clearly indicated as evidenced by dominant mutations in three different genes have been identified that account for the small number of cases of familial, early - onset AD.

Carriers of BRCA2 mutations composed a smaller sample set; in particular, the number of women with BRCA2 - associated ovarian cancers was relatively small.

To date, no links between the small number of patients infected with the mutated virus have been found and the mutation does not appear to spread.

Lung cancer treatment is an evolving field of science, currently there are several pathways under investigation as a possible treatment target.1 - 3 Targeted treatment is currently considered to be more efficient compared to the non-specific cytotoxic drugs, however; the small number of patients identified with mutations, limit the application of these drugs.

Mutations in CDKN2A account for approximately 40 % of familial cases, and predisposing mutations in CDK4 have been reported in a very small number of melanoma Mutations in CDKN2A account for approximately 40 % of familial cases, and predisposing mutations in CDK4 have been reported in a very small number of melanoma mutations in CDK4 have been reported in a very small number of melanoma kindreds.

This work shows that TREM2 is important not just in the relatively small number of patients carrying mutations, but potentially in all of Alzheimer's.»

We found mutations in a gene called «POT1» that increased the risk of melanoma in a small number of these families.

Still, some of those common variants may contribute in a small way to the risk of ASD, and if a child inherits a significant number of risky mutations, the combination might cross the threshold for developing the disorder.

First it will be necessary to formally exclude the COMMD1 gene by sequencing all of COMMD1 in a small number of affected dogs that are known to not carry the COMMD1 deletion to ensure there is not a second mutation in the same gene.

The same mutation has also been identified in a small number of French bulldogs with a clinically identical cataract (Mellersh, unpublished).