The researchers found that strains of
Mycobacterium smegmatis in which the genes for the hydrogenases or the regulator DosR had been «knocked out» experienced a hundredfold reduction in the long - term survival compared to the normal bacterium, he says.
Working with a non-pathogenic cousin of M. tuberculosis called
M. smegmatis, the team used a mutant form of the bacteria that lacked the part of RbpA that interacts with fidaxomicin.
Professor Cook's team have established that Mycobacterium
smegmatis metabolises molecular hydrogen using three enzymes called hydrogenases.
In a lawsuit filed 23 February, Illumina suggested that Oxford Nanopore used a bacteria - derived pore called Mycobacterium
smegmatis porin (Msp).
In collaboration with researchers in the US and Germany, Otago microbiologists have teased out the mechanisms by which the aerobic soil microbe
Mycobacterium smegmatis is able to persist for extreme lengths of time in the absence, or near - absence, of oxygen.
Aldridge and her team, including Kirill Richardson, M.S., research technician in Aldridge's lab, based their study on Mycobacterium
smegmatis, a fast - growing, non-pathogenic relative of M. tuberculosis.
Eric J. Rubin, M.D., Ph.D., of Harvard T.H. Chan School of Public Health, and E. Hesper Rego, Ph.D., of Yale University School of Medicine, and their coworkers first studied Mycobacterium
smegmatis, a close relative of Mycobacterium tuberculosis (Mtb), the microbe that causes TB.
One such MDR bacterium is Mycobacterium tuberculosis, the causative agent of TB, whose phages can be isolated on the easy - to - grow non-pathogenic Mycobacterium
smegmatis.