Grants issued last summer totaling nearly $ 50 million will go toward producing the first 8,500 or
so of the cell lines, each carrying one disabled, or «knocked out,» gene.
Not exact matches
For example, if I come from a long
line of brown - eyed people, can I aim to alter the DNA molecules in my reproductive
cells so as to pass on to my son «genes for blue - eyedness»?
Newborns typically have loose junctures between the
cells of the stomach
lining,
so during the first few months
of life, these junctures grow tighter as your baby's protective tummy barrier matures.
«It has the magic
of both great antibody response and inducing a strong, strong T
cell response that will be a safety net —
so if a virus breaks through the first
line of defense, you will have T
cells to make sure you don't get very sick,» Sullivan says.
The year's most prominent science issue, federal support
of embryonic stem
cell research, is
so controversial that the sons
of Ronald Reagan gave dueling speeches at the opposing party conventions; Michael Reagan backs President George W. Bush's policies, including the ban on funding for research on new stem
cell lines, while Ron supports Senator John Kerry's promise to lift restrictions.
The unaltered hemagglutinin is akin to a key that unlocks a
so - called receptor molecule in
cells lining the upper airways
of humans and other mammals.
First she deprived juveniles
of vision in one eye
so that the corresponding brain
cells failed to make connections; once the mice reached maturity, they were put in a water maze that required them to recognize a pattern
of fine
lines to find a floating platform.
When they think about how
cells put together the molecules that make life work, biologists have tended to think
of assembly
lines: Add A to B, tack on C, and
so on.
At perhaps 11,000 years old, CTVT is the oldest known
line of mammalian
cells on Earth,
so it's no longer evolving much.
As other researchers asked for samples, the
cells replicated, grew, and proliferated
so wildly that they often took over and wiped out
cell lines of any kind with which they happened to come in contact.
(Federal funding restrictions forbid National Institutes
of Health - funded labs from working on the
cells, because they were derived via cloning,
so recipients also need to show that they have a legal place to work with the
cell lines.)
A study combining tumor
cells from patients with breast cancer with a laboratory model
of blood vessel
lining provides the most compelling evidence
so far that a specific trio
of cells is required for the spread
of breast cancer.
Proponents
of ESC research counter that most
of the new
cell lines could be derived from donated, unused human embryos created by couples seeking fertility treatment, and that more than a third
of zygotes fail to implant after conception,
so those would be lost by chance anyway.
And
so, you know, again theoretically, you could take one stem
cell line and create tens
of thousands
of tons
of food.
«The beautiful thing,» Lanza says, «is that if you have an embryonic stem
cell line that is O negative, because it's immortal you could create an unlimited amount
of universal blood that would match virtually everybody,
so you wouldn't have to worry about matching blood types.»
So far, Menendez and his colleagues have discovered the fatty acid cuts the expression
of the gene in ovarian, stomach, and colon cancer
cell lines.
In the different
cell types, the loops begin and end at different specific chromosomal locations,
so each
cell line's genome appears to have a unique population
of loops.
Moreover,
cell lines vary in their ability to make different tissues, such as heart muscle or cartilage,
so a suite
of clinical - grade
lines is needed, Braude says.
The only stem
cell research he would permit, Bush said, was research using existing embryonic
lines as well as
so - called adult stem
cells, which occur in anyone
of any age.
Before dividing, pairs
of identical chromosomes
line up in the middle
of the elongated
cell, and the microtubules, emanating out from the centrioles on either side, help pull the chromosomes in opposite directions
so that each new
cell receives one member
of each chromosome pair.
Researchers have conducted
so many studies with HeLa
cells that they've become somewhat
of a problem; scientists will periodically suffer the embarrassment
of finding that HeLa
cells contaminate their other
cell lines.
With
so much work needed in studying the nature
of stem
cells and using them to study disease processes, therapies based on ES
cells seem very far down the
line, noted Lorenz Studer
of Memorial Sloan - Kettering Cancer Center in New York, who pointed out that
so far there have only been two published papers on therapeutic cloning, both
of them in mice.
GM - CSF is thought to act by moving progenitor
cells out
of the bone marrow
so that they can replenish the
linings of blood vessels.
The group urged the creation
of two central databases: One on stem
cell lines in use worldwide and one on intellectual property rights
so scientists can readily access information.
They're carried in the blood and must get past the
so - called blood - brain barrier, composed
of specialized
cells lining the walls
of capillaries in the brain.
To do
so, they started with a human embryonic stem
cell line, which they chemically nudged to become
cells that form what's known as the primitive streak on the hollow ball
of cells of the early embryo.
Endothelial progenitor
cells (EPCs) differentiate into the
cells that make up the
lining of blood vessels, and
so play roles in vasculogenesis and angiogenesis.
The Joslin team found that intestinal tumors grow just as quickly in a mouse cancer model whose «epithelial»
cells lining the inside
of the intestine have been genetically modified
so that insulin can't activate the
cells.
In goblet
cell metaplasia, exposure to allergens such as pollen, mold and dust mites initiates a series
of biochemical reactions that causes the
cells that
line the air passages
of the lungs to change from their normal state into
so - called «goblet
cells,» which produce substantial amounts
of excess mucus.
These bacteria often take up residence inside
cells lining the intestine, but they employ different methods
of doing
so.
Despite the long
lines outside
of technology stores anytime a new gadget is released, there was a time not
so long ago when people in the United States actually went about their days minus
cell phones, personal computers, electronic readers and televisions.
And then our newest
line of research is relevant to
cells in the spinal cord,
so I'm especially excited to come to Gladstone and find new collaborators to work with on that project.
(The first
line of human
cells to survive in vitro is the
so - called HeLa
cells, grown in 1951 — it's still the most commonly used
cell line for human
cell research.)
Newer
lines of research are focused on understanding cancer stem (CSC)
cell biology
so that therapies targeting them can be developed.
Conversely ghrelin, produced mainly by P / D1
cells lining the fundus
of the stomach, exerts appetite stimulating effects and
so levels are typically at their peak pre-meal and decrease post - prandially.87 As weight - loss is associated with increased fasting levels
of ghrelin 88 and reduced suppression in response to a meal in obese subjects 89, changes in circulating ghrelin levels have been assessed in several IER studies.
«It makes the
cells that
line the gut healthier,» says Chris Kresser, author
of Unconventional Medicine and co-founder
of the California Center for Functional Medicine, «
so you don't have that permeability.
Our gut
lining is one
of the most active sites
of cell production and growth, which requires a good supply
of natural Vitamin A. Poor digestion causes Vitamin A deficiency, and gut disease is a symptom
of Vitamin A deficiency,
so this is a sort
of «chicken and egg» relationship.
We want to have phytosterols constantly flowing through our gut throughout the day,
so they'll continue to keep stuffing the bins
of our intestinal
lining cells, allowing excess cholesterol to pass.
You allow your gastrointestinal
lining more time to recover and rebuild, bearing in mind the
cells of your gut
lining like to replace themselves every 2 days as compared with every 8 years or
so for the neurons in your brain.
Intestinal mucosal
cells are replaced within 6 days; this means that there is a tremendous turnover
of cells, even more
so for people with conditions exhibiting damage to the gut
lining.
So, you get some extreme damage and you get lots
of basically wearing away
of this single
cell lining between your small intestine and your blood stream.
Gift Idea: Along with the Citrus Stem
Cell Serum, give them our Normal Skin Travel Kit,
so they can try more
of our
line!
It works to activate the skin's defence
line cells (Langerhan
cells) and in doing
so it assists in a complete rejuvenation
of the skin's texture with improvement in skin elasticity, strength and hydration.
I was surprised to hear that I needed to be moisturizing and exfoliating more often to reduce dryness and the amount
of dead skin
cells I had causing those fine
lines I was trying
so hard to erase.
Ninety minutes on the origins
of the
so - called HeLa
cell line sound about as dramatically inviting as a teeth - cleaning.
I can't think
of another game
so destroyed by its dialogue as Splinter
Cell: Conviction; not by bad
lines alone (which are nothing novel in gaming) but by the way Ubisoft's designers and programmers used them.
But
so great is this culture's obsession with her that Syd has developed a nice little side -
line peddling her infections on the black market to a man who, by day, sells celebrity steaks grown from the
cells of the star
of your choosing.
There is probably nobody out there who has not had to deal with the pitfalls
of the modern - day conference call: crying babies or dogs barking on the
line of the person working from home; the dude calling in from his
cell phone with bad reception; the lady dialing in from the airport with flight announcements on the P.A. system interrupting every 30 seconds; the loud talker; the soft talker; the foreign accent - talker you can not understand; the two people who keep talking over each other; the business - speak cliches you must endure («at the end
of the day»); and
so on.