Sentences with phrase «social defeat»

At the same time, the rodents had an even greater response to social defeat stress than normal mice do, suggesting their brains also are more susceptible to a depressive - like state.
Then they recorded brain activity as these mice were subjected to a stressful situation called chronic social defeat.
Again, the three groups of mice were exposed to the stressful experience of social defeat in the cages of other more aggressive mice.
Three groups of mice were individually placed in cages with aggressive mice and experienced social defeat, a stressful experience for them.
The authors suggested that moving schools often may lead to feelings of low self - esteem and a sense of social defeat.
The effect of escapable versus inescapable social defeat on conditioned defeat and social recognition in Syrian hamsters.
Our goal in using this multifaceted model was two-fold 1) to confirm and further characterize the distinct behavioral traits in animals most susceptible to social stress after going through the 10 - day social defeat paradigm compared to undefeated control animals; 2) to provide pharmacological validation for this model using standard antidepressant medications such as fluoxetine and imipramine.
Specifically, our data with the CSDS model suggests that animals most susceptible to social stress after going through the 10 - day social defeat paradigm exhibit increased social avoidance behavior, anhedonia and potentiated fear responding to sound cues.
Taylor, S.L., Stanek, L.M., Ressler, K.J., and Huhman, K.L. Differential brain - derived neurotrophic factor expression in limbic brain regions following social defeat or territorial aggression.
Research synopsis: The title of the research project that Katharine discussed at the conference is Social defeat in Syrian hamsters: Controllability, duration and social recognition.
Individual differences in novelty seeking predict subsequent vulnerability to social defeat through a differential epigenetic regulation of brain - derived neurotrophic factor expression
Behavioral Characterization and Pharmacological Validation of Chronic Social Defeat Stress Mouse Model I. MORGANSTERN, S. DAVIS, K. HOMA, E. SABATH, T. HANANIA... Abstract / Posters
(Nestler was at The University of Texas Southwestern Medical Center when his group started studying what researchers call chronic social defeat stress.)
These data suggest that for hamsters the ability to control (i.e., escape from) a socially stressful situation does not reduce the effect of social defeat on subsequent agonistic behavior.
Jeffress, E.C. and Huhman, K.L. Copulatory and agonistic behavior in Syrian hamsters following social defeat.
Looking inside the brains of animals exposed to chronic social defeat stress, the scientists observed hyperactive firing of neurons in the ventral tegmental area (VTA), a critical part of a reward circuit.
«Children spend substantial time with their siblings in the confinement of their family home and if bullied and excluded, this can lead to social defeat and self - blame and serious mental health disorder — as shown here for the first time.»
To demonstrate the effects of bullying, the researchers used an animal model simulating the physical and emotional stressors involved in human bullying — chronic social defeat stress.
By comparing gene expression in the brains of resilient and avoidant mice, Berton and colleagues discovered that bullying in avoidant mice puts GABA neurons in a state where they become more excitable and the mice exhibit signs of social defeat.
The Chronic Social Defeat Stress (CSDS) mouse model has received much interest recently as it closely mimics the dynamic range of individual responses to stressors such as the development of a major depressive disorder, anxiety, post-traumatic stress disorder or resil ¬ iency to these disease states.
While the Huhman laboratory primarily uses inescapable social defeat to model the clinical psychopathologies (e.g., anxiety, posttraumatic stress disorder) that can result from bullying or abuse, researchers have also shown that exposure to escapable social defeat results in CD, albeit to a reduced degree.
Using a yoked design, it was demonstrated that when the duration of social defeat was held constant, there was no effect of controllability on CD behavior exhibited during testing as shown by the finding that the two groups exhibited similar levels of CD.
This phenotype of susceptible mice showed very high discrimination from control undefeated animals, which was evident as long as 6 weeks after the social defeat stress.
After one social defeat, hamsters abandon all territorial aggression and become highly submissive, even towards a non-threatening social stimulus such as a caged hamster or a smaller, non-aggressive opponent.
Our findings first confirmed previous work with this model in demonstrating that compared to undefeated control animals, mice most susceptible to social defeat stress demonstrated a number of abnormalities in social avoidance, depression and anxiety as measured by routine test procedures.
The current series of studies present findings from two animal models of PTSD, namely the mouse chronic social defeat (CSDS) model (Berton et al., 2006; Golden et al., 2011) recently developed in collaboration with Dr. Eric Nestler and also the fear - conditioned, Wistar - Kyoto (WKY) rat model (DaSilva et al., 2011; 2013).
These analyses demonstrated very unique and specific behaviors related to anxiety and fear of the susceptible versus control mice that progressed over time and were evident as long as 6 weeks after the social defeat stress.
We have submitted Cbg ko and wild - type (WT) male mice to two different chronic stress paradigms - the unpredictable chronic mild stress and the social defeat.
Effects of the Novel Anti-Asthenic Drug Ladasten on Behavior and T - Cell Subsets Alterations in a Social Defeat Animal Model of Depression
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