Sentences with phrase «social defeat paradigm»

Specifically, our data with the CSDS model suggests that animals most susceptible to social stress after going through the 10 - day social defeat paradigm exhibit increased social avoidance behavior, anhedonia and potentiated fear responding to sound cues.

Our goal in using this multifaceted model was two-fold 1) to confirm and further characterize the distinct behavioral traits in animals most susceptible to social stress after going through the 10 - day social defeat paradigm compared to undefeated control animals; 2) to provide pharmacological validation for this model using standard antidepressant medications such as fluoxetine and imipramine.