Our findings first confirmed previous work with this model in demonstrating that compared to undefeated control animals, mice most susceptible to
social defeat stress demonstrated a number of abnormalities in social avoidance, depression and anxiety as measured by routine test procedures.
The Chronic
Social Defeat Stress (CSDS) mouse model has received much interest recently as it closely mimics the dynamic range of individual responses to stressors such as the development of a major depressive disorder, anxiety, post-traumatic stress disorder or resil ¬ iency to these disease states.
At the same time, the rodents had an even greater response to
social defeat stress than normal mice do, suggesting their brains also are more susceptible to a depressive - like state.
To demonstrate the effects of bullying, the researchers used an animal model simulating the physical and emotional stressors involved in human bullying — chronic
social defeat stress.
Looking inside the brains of animals exposed to chronic
social defeat stress, the scientists observed hyperactive firing of neurons in the ventral tegmental area (VTA), a critical part of a reward circuit.
Not exact matches
While the Huhman laboratory primarily uses inescapable
social defeat to model the clinical psychopathologies (e.g., anxiety, posttraumatic
stress disorder) that can result from bullying or abuse, researchers have also shown that exposure to escapable
social defeat results in CD, albeit to a reduced degree.
Our goal in using this multifaceted model was two-fold 1) to confirm and further characterize the distinct behavioral traits in animals most susceptible to
social stress after going through the 10 - day
social defeat paradigm compared to undefeated control animals; 2) to provide pharmacological validation for this model using standard antidepressant medications such as fluoxetine and imipramine.
Specifically, our data with the CSDS model suggests that animals most susceptible to
social stress after going through the 10 - day
social defeat paradigm exhibit increased
social avoidance behavior, anhedonia and potentiated fear responding to sound cues.
We have also found that control and
defeated (
stressed) Cbg ko mice show no difference in the
social interaction test, while
defeated WT mice reduce their interaction time when compared to unstressed WT mice.
We discuss the truth behind making a profit on wellness, Dr. Chopra's spiritual belief systems, his exact morning routine, how to raise a conscious and mindful kid, his surprising
social media practices, how he's managed to avoid all
stress for the last 35 years, and the philosophies he thinks will help us
defeat the current global insanity crisis going on in the world today.