Sentences with phrase «sodium channel»

The new antibody works by targeting the voltage - sensitive sodium channels in the cell membrane of neurons.

Up until now there has been an assumption that individual sodium channels function independently.

This molecule is particularly important in regulating sodium channels located on heart cells.

The researchers suggest that the enzymes could be modifying sodium channels, which would increase the amount of sodium that gets into cells.

But there are nine similar sodium channels responsible for a variety of functions in the body.

The equivalent sodium channel in humans could be a target for preventing the pain caused by acid build - up, a symptom of arthritis.

Like a type of door, sodium channels allow sodium ions to flow into nerve cells through tiny pores.

What it does is that it keeps sodium channels open in the cell membrane.

Small changes in the protein sequence of sodium channels of American compared with German cockroaches leave the latter susceptible to a venom that has little effect on the former.

«However, this did not reveal any increased formation of sodium channel proteins, which could have explained the overexcitation of nerve cells.»

A research group led by Professor Takahashi in collaboration with researchers in the France, United States, Germany, Finland, Spain and Taiwan found that there were RNA splicing abnormalities in the cardiac sodium channel in DM patients.

Spiders, Centipedes and Scorpions Not just any venomous creature will do to create sodium channel blockers.

Pyrethroids, the main class of pesticides used against bedbugs today, targets sodium channels in bedbug cells, just like DDT.

The team first tested the antibody in cultured cells engineered to express the Nav1.7 sodium channel.

«The [pain] signal might get generated by sodium channel 1.7, but it does not get sent to the brain by 1.8,» Rowe says.

Moreover, problems in sodium channels play a role in epilepsy and heart disorders — both common in children with SIDS.

The researchers found that, in mice lacking the fragile X protein, mGluR5 provides a signal to modify a kind of sodium channel so that such channels persistently allow too much sodium to flow into neurons.

This region of the 3 - subunit lies on the outside of the cell and binds to the heart sodium channel α - subunit.

Among other things, this means CFTR loses the ability to control a protein called the epithelial sodium channel (ENaC).

When the neuron gets a cue, gates on sodium channels are thrown open, ions rush in, and the voltage surges.

In this case, over time, amino acids in three different sodium channels found in nerves and muscle changed, allowing select snakes to resist the numbness and paralysis typically brought on by the toxin.

Dravet syndrome is one of the most challenging forms of childhood epilepsy, resulting from a specific genetic mutation that affects sodium channels in the brain.

Nerves can partially compensate for this damage with an increase of molecular gates called sodium channels.

Its additional sodium channels now malfunction, and the axon tries to compensate by creating even more channels.

To get nanoparticles to stick, Bezanilla and his team coupled them to a synthetic molecule based on Ts1, a scorpion neurotoxin, which binds to sodium channels without blocking them.

Voltage - sensitive sodium channels control the flow of sodium ions through the neuron's membrane.

«We thought that the conflicting results for sodium channels might be related to difficulties in existing methods to control the calcium concentrations that might affect these channels,» Ben - Johny says.

When nerve cells receive a signal of pain or other sensation, the signal opens sodium channels and floods the cell with positively charged sodium ions, which positively charge the neurons until the electrochemistry changes enough to inactivate the channels and close them.

Approximately 80 % of Dravet patients have mutations in the gene SCN1A which encodes the Nav1.1 sodium channel, however for the remaining 20 % of patients the underlying genetic cause has yet to be determined.

The group electrophysiologically examined the function of an abnormal sodium channel and found that it was compromised.

In addition, a computer simulation demonstrated that the compromised sodium channel function caused abnormalities in an electrocardiogram, which was similar to abnormalities in patients.

This enabled them to «smuggle» calcium ions into cells and see what happened to sodium channels when the calcium concentration changed abruptly.

Structural studies give insight into how a human sodium channel involved in pain perception can be selectively inhibited.

Further research determined that certain components of the cone snail venom, called conotoxins, targeted voltage-gated calcium channels, which, like sodium channels, handle communication between pain - sensing neurons and the brain.

Dr Chirgadze added: «Our research has important implications for our understanding of the mechanism of sodium channel behaviour.

«Without [sodium channel] 1.7, the pain signals simply don't get amplified to a level where it gets the signal up to the spinal cord and up to the brain,» so the brain never knows about it, he says.

Recent research shows that scorpion venom, too, can be a potent sodium channel blocker.

Their venom peptides hit a wide variety of pain targets, including sodium channels, calcium channels and other receptors.

King believes that venom - based peptides — short chains of amino acids — are better at being selective than small molecules because the venom peptides don't target the pore; they target a specific sodium channel switch.

When researchers talk about channel selectivity, they're referring to the ability of peptides or small molecules to turn off only one particular sodium channel.

In contrast, turning the switch permanently on led to increased late sodium channel current and arrhythmias even at baseline.

«This study identifies a specific site on the channel we can target to preserve normal sodium channel and heart function even under chronic stress,» Hund said.

«We know dysregulation of a protein enzyme called multifunctional CaM kinase II plays a role in disrupting sodium channel function in cardiac disease, but it was a matter of determining how this occurred and whether we could we prevent it for therapeutic benefit,» said Hund, an associate professor of biomedical engineering at The Ohio State University.

Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons.

Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium - sensitive weakness.