This enabled them to «smuggle» calcium ions into cells and see what happened to
sodium channels when the calcium concentration changed abruptly.
Not exact matches
When the neuron gets a cue, gates on
sodium channels are thrown open, ions rush in, and the voltage surges.
When bulky amino acids are introduced at these positions, the
channel width no longer corresponds to the size of
sodium ions, and instead cesium ions are transported.
When researchers talk about
channel selectivity, they're referring to the ability of peptides or small molecules to turn off only one particular
sodium channel.
When appropriately stimulated, the
channels open,
sodium ions flow in, and the muscle cells contract.
When nerve cells receive a signal of pain or other sensation, the signal opens
sodium channels and floods the cell with positively charged
sodium ions, which positively charge the neurons until the electrochemistry changes enough to inactivate the
channels and close them.
Zheng, being a membrane protein rookie, had what he calls a stroke of beginners luck
when he and his team solved the structure for a voltage-gated
sodium channel, a
channel others in the field had long been working to solve.
When stimulated, the
channels open and
sodium rushes in changing the chemical gradient (middle, below), which in turn causes nearby
channels to open and so on; if the neuron reaches a certain threshold of open
channels, it fires an electrical impulse.