Trends in 24 - h urinary
sodium excretion in the United States, 1957 - 2003: a systematic review.
He and a colleague reviewed studies between 1957 and 2003 that measured
sodium excretion in urine — a very accurate way of determining salt intake that gets around the difficulties in figuring out exactly how much salt is in your food.
But approximately 90 percent of the participants in the PURE study had either a high (greater than 5.99 grams per day) or moderate (3 to 5.99 grams per day) level of sodium excretion; approximately 10 percent excreted less than 3 grams per day, and only 4 percent had
sodium excretion in the range associated with current U.S. guidelines for sodium intake (2.3 or 1.5 grams per day).
Not exact matches
«Further, the study also showed that consuming larger amounts of potassium
in the diet counterbalances the adverse affect of high
sodium excretion on blood pressure
in cardiovascular disease outcomes.»
Danish researchers have found that sleep deprivation causes healthy children, between the ages of eight and twelve, to urinate significantly more frequently, excrete more
sodium in their urine, have altered regulation of the hormones important for
excretion, and have higher blood pressure and heart rates.
This measure, known as 24 - hour urinary
sodium excretion, provides a rough estimate of the amount of
sodium a person consumed
in the previous day.
In the CKD study, BMI and sex were the primary cardiovascular risk variables but
sodium excretion also contributed to cardiovascular risk of hypertensives.
The «wildly speculative values» of 3 to 7 grams per day referred to by Cordain came from a cohort study published
in 2011
in The Journal of the American Medical Association
in which
sodium intake of almost twenty - nine thousand patients with established cardiovascular disease or diabetes mellitus was estimated by twenty - four - hour urinary
sodium excretion.26 During the follow - up of fifty - four months, the study found that daily
sodium intake below three grams and above seven grams significantly increased cardiovascular risk.
Mente, A, O'Donnell M, Rangaranjan S and others: «Associations of urinary
sodium excretion with cardiovascular events
in individuals with and without hypertension: a pooled analysis of four studies:» Lancet 2016 May 20.
The majority of subjects
in both studies were overweight and obese.8 Obesity is associated with increased
sodium excretion and with increased cardiovascular risk.
In the lowest category of sodium excretion, with an average of 1.9 grams per day, the percentage of subjects that had CVD events was higher (7.2 percent) than that of the second category (6.8 percent), with average excretion of 3 grams per day, even though the average BMI and percentage of high - risk males was lower in the lowest categor
In the lowest category of
sodium excretion, with an average of 1.9 grams per day, the percentage of subjects that had CVD events was higher (7.2 percent) than that of the second category (6.8 percent), with average
excretion of 3 grams per day, even though the average BMI and percentage of high - risk males was lower
in the lowest categor
in the lowest category.
The observed increase
in mortality and CVD events among those with daily
sodium excretion less than 3 grams is consistent with the findings of many other studies.3, 4,6,7,22 During follow - up, one hundred twenty - six patients (4.5 percent) developed end - stage renal disease (ESRD).
SODIUM EXCRETION AND RISK OF CARDIOVASCULAR DISEASE IN PATIENTS WITH KIDNEY DISEASE A second study cited by the CDC under the consistency criteria, «Sodium excretion and risk of cardiovascular disease in patients with chronic kidney disease» 7 included 3757 subjects with chronic kidney disease (CKD), 55 percent males, who experienced 804 CVD events during 6.8 years follow
SODIUM EXCRETION AND RISK OF CARDIOVASCULAR DISEASE IN PATIENTS WITH KIDNEY DISEASE A second study cited by the CDC under the consistency criteria, «Sodium excretion and risk of cardiovascular disease in patients with chronic kidney disease» 7 included 3757 subjects with chronic kidney disease (CKD), 55 percent males, who experienced 804 CVD events during 6.8 years fol
EXCRETION AND RISK OF CARDIOVASCULAR DISEASE
IN PATIENTS WITH KIDNEY DISEASE A second study cited by the CDC under the consistency criteria, «Sodium excretion and risk of cardiovascular disease in patients with chronic kidney disease» 7 included 3757 subjects with chronic kidney disease (CKD), 55 percent males, who experienced 804 CVD events during 6.8 years follow - u
IN PATIENTS WITH KIDNEY DISEASE A second study cited by the CDC under the consistency criteria, «
Sodium excretion and risk of cardiovascular disease in patients with chronic kidney disease» 7 included 3757 subjects with chronic kidney disease (CKD), 55 percent males, who experienced 804 CVD events during 6.8 years follow
Sodium excretion and risk of cardiovascular disease in patients with chronic kidney disease» 7 included 3757 subjects with chronic kidney disease (CKD), 55 percent males, who experienced 804 CVD events during 6.8 years fol
excretion and risk of cardiovascular disease
in patients with chronic kidney disease» 7 included 3757 subjects with chronic kidney disease (CKD), 55 percent males, who experienced 804 CVD events during 6.8 years follow - u
in patients with chronic kidney disease» 7 included 3757 subjects with chronic kidney disease (CKD), 55 percent males, who experienced 804 CVD events during 6.8 years follow - up.
Mills KT and others: «
Sodium excretion and risk of cardiovascular disease
in patients with chronic kidney disease» JAMA 2016 May 24 - 31; 31 (20): 2200 - 10.
The percentage of CKD patients who had cardiovascular events during follow - up was higher (18.4 percent)
in the lowest quartile of urinary
sodium excretion (average
excretion 2.5 grams per day) than the 16.5 percent
in the second quartile (average
excretion 3.3 grams per day).
The reference range of 4 to 5 grams per day was used
in assessing the risk of
sodium excretion above and below the reference range.
but only
in the highest quartile of
sodium excretion.
It is noted that a
sodium intake of less than 2 grams per day, which approximates the
sodium intake of the paleo diet with no added salt, was associated with a 68 percent increase
in cardiovascular disease risk during follow - up of fifty - four months
in the study reviewed
in the Kresser blog.26 Another study, which excluded subjects with cardiovascular disease, hypertension and diabetes, found that after thirty - three months, the cardiovascular risk of those with daily
sodium excretion of 1.9 grams was 36 percent higher after adjustment for body mass index and sex than the risk of those excreting 3 grams.6
The
sodium excretion of the study subjects of 3.8 grams per day was significantly higher than the average
sodium excretion of around 3.4 grams per day
in the U.S. and Canada.
However,
in the Hamilton
sodium studies, assessments of the association between
sodium excretion and CVD risk were made
in which subjects with such preexisting conditions were excluded, with no significant effects on outcomes.
Table 1 below includes pertinent data on BMI and number and percentage of males by category of urinary
sodium excretion, together with the percentage of subjects
in each category who experienced CVD events during follow - up.
In contrast, a negligible percentage of the population of the U.S. and Canada are at increased risk due to
sodium excretion of more than 7 grams / day.
These values are derived from twenty - four - hour urinary
sodium excretion measurements
in studies involving over one hundred thousand participants.4 Cordain implies that
sodium intake
in «non-westernized people» is far lower than
in the US, but
in fact the average daily
sodium intake
in Asia, Africa and the Middle East is about 50 percent higher than the 3.4 grams per day
in the U.S. and Canada.24, 25
Mente A, and others «Assessment of urinary
sodium and potassium
excretion in Canadians using 24 - hour urinary
excretion» Can J Cardiol 2016 Mar; 32 (3): 319 - 26.
When
sodium excretion exceeded 7 grams per day there was no significant change
in risk (hazard ratio 0.90).
Fatal and nonfatal outcomes, incidence of hypertension, and BP changes
in relation to urinary
sodium excretion.
In addition, it improves endothelial function and arterial flexibility, improves blood and oxygen supply to the heart, reduces platelet aggregation, and has a mild hypotensive effect via vasodilation and the promotion of
sodium excretion.
In the kidneys, dopamine increases the
excretion of
sodium, as well as the urine output.
This allows the
excretion of extra retained
sodium and fluid
in the urine.
Fatal and Nonfatal Outcomes, Incidence of Hypertension, and Blood Pressure Changes
in Relation to Urinary
Sodium Excretion.
In the process, sodium is lost too, and it may result in lowered blood pressure (in Overlack et al. the counter-regulators had 10 % higher average sodium excretion than salt - resistant group, and 20 % higher than salt - sensitive group
In the process,
sodium is lost too, and it may result
in lowered blood pressure (in Overlack et al. the counter-regulators had 10 % higher average sodium excretion than salt - resistant group, and 20 % higher than salt - sensitive group
in lowered blood pressure (
in Overlack et al. the counter-regulators had 10 % higher average sodium excretion than salt - resistant group, and 20 % higher than salt - sensitive group
in Overlack et al. the counter-regulators had 10 % higher average
sodium excretion than salt - resistant group, and 20 % higher than salt - sensitive group).
-RCB- elevated
sodium level within kidneys, either as a result of pathological bottleneck such as reduced number of nephrons, or simply due to heightened intake - or both - may activate pro-inflammatory cytokines and chemokines
in proximal tubular cells, may cause oxidative stress by activating ROS - producing NADH oxidase enzymes, or blood vessel constriction by inhibiting kidney arginine transport and nitric oxide synthesis; elevated renal inflammation, oxidative stress and restricted blood flow all can impair the efficacy of
sodium excretion, more so combined (if extensive, it can also result
in post-natal reduction of nephron units)
And levels of urinary
sodium excretion were inversely related to the risk of dying of cardiovascular causes, Staessen and colleagues reported
in the May 4 issue of the Journal of the American Medical Association.
It's important to maintain a balance between
sodium and potassium
in the diet, because
sodium intake can affect potassium
excretion, and vice versa.
In each group, urinary sodium excretion changed little between the run - in and intervention phase
In each group, urinary
sodium excretion changed little between the run -
in and intervention phase
in and intervention phases.
Results were similar after adjustment for changes
in weight and urinary
sodium excretion.
One measured fluid, electrolyte, and renal indices of hydration over eleven days of caffeine consumption
in human subjects, finding that doses of up to 6 mg caffeine per kilogram of body weight had no effect on body mass, urine osmolality (urine concentration), urine specific gravity (concentration of excreted materials
in urine), urine color, urine volume,
sodium excretion, potassium secretion, creatinine content, blood urea nitrogen (forms when protein breaks down), and serum levels of
sodium and potassium.
Studies have shown that the absorption, distribution, and
excretion of selenium
in food were distinctly different from those
in sodium selenite.
Aldosterone hormone regulates the electrolyte and water balance of the body and is involved
in the
excretion of potassium and retention of
sodium.