Sentences with phrase «soft agar»
"Soft agar" refers to a special gel-like substance commonly used in scientific experiments. It helps scientists grow and study cells outside the body in a controlled environment. Full definition
By using molecular genetic tools to reduce the amount of PC in human lung cancer cells, the team observed decreased cell growth, a compromised ability to form colonies in soft agar (a gelatinous material specifically used to grow bacteria and other cells), and a reduced rate of tumor growth in mice.
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This resulted in a reduced 7SK snRNA level and caused a significant increase in cell proliferation and anchorage - independent growth in soft agar (Figure 3B — D, Figure 3 — figure supplement 1B — D).
(E) Rat1 - DD cells expressing kinase - inactive alleles of MELK (D150A or T167A), fail to grow as colonies in soft agar.
Unlike Rat1 - DD - MELK cells, both Rat1 - DD - MELK - D150A and Rat1 - DD - MELK - T167A cells exhibited only limited growth in soft agar or in mice (Figure 4D — F).
Regarding the transformation of HMECs, we and others have shown that mutant PIK3CA, Ras or NeuT alone can induce colony formation of HMEC - DD cells in soft agar, but is not sufficient to promote tumor formation of these cells in mice (Hahn et al., 1999; Zhao et al., 2003; Zhao et al., 2004).