Sentences with phrase «solid tumor types»

«ECHO - 203 is part of the broader ECHO clinical development program investigating efficacy and safety of epacadostat as a core component of combination therapy in a broad range of solid tumor types as well as hematological malignancies,» said Naing.

A combination of the indoleamine 2,3 - dioxygenase 1 (IDO1) inhibitor epacadostat with the anti — programmed death ligand 1 (PD - L1) antibody durvalumab was well tolerated in a phase I trial of patients with multiple solid tumor types.

Our research shows that Tumor Treating Fields have an antimitotic effect in more than 18 solid tumor types in culture and in eight in vivo tumor models.

The study evaluated the efficacy and safety of cabozantinib compared to placebo in 9 different solid tumor types including breast, lung, ovarian, and prostate.

The FDA granted accelerated approval to pembrolizumab (Keytruda, Merck) as a second - line treatment for all metastatic solid tumor types classified as MSI - hi (high microsatellite instability) or dMMR (deficient DNA mismatch repair).

Not exact matches

Right now, that's where most of the big successes have come from, but that could one day include solid tumors and maybe even autoimmune diseases like Type 1 diabetes, Epstein said.

While more sensitive assays have enabled doctors to take smaller samples of some types of solid tumors, oncologists have long dreamed of avoiding traditional biopsies altogether.

Brain tumors are the most common type of solid cancer in children, but they're still poorly understood,» Venneti says.

«It's very difficult to produce a mouse model of a solid tumor of the type we see in most women who are diagnosed with cervical cancer.

The findings also have potential uses for most other types of solid tumors, including those affecting the lungs and ovaries, because the same protein and enzyme are involved, François said.

Consequently, «metformin is being studied in various solid tumors,» Karmalis says, «and has the potential to change treatment paradigms for a number of cancer types,»

«Deficiencies in repair of DNA identified in many types of solid tumors.»

That's why we applied different cancer types — not just for solid tumors, but for cancers like leukemia,» Gu said.

«But mounting evidence confirming angiotropism and EVMM has revolutionized the knowledge of how cancer spreads through the body to the point that other scientists have confirmed the process in other solid tumor cell types such as pancreatic cancer.»

Caris performed the molecular profiling on 48,733 solid tumor samples to assess the prevalence of homologous recombination deficiency in about 20 different types of solid tumors.

Purushotham points out, «The feasibility of intraoperative CLI as shown in this study, in combination with the wide applicability of F -18-FDG across a range of solid cancers, provides a stepping stone for clinical evaluation of this technology in other solid cancer types that also experience incomplete tumor resection due to close or involved margins.»

The research team of Dr Bassam Janji in the Laboratory of Experimental Cancer Research at LIH's Department of Oncology is specialized in the study of the tumor microenvironment in different types of solid tumors, including skin cancer.

In the new study, scientists built upon previous discoveries that a safe, non-reproducing vaccine strain of T. gondii could cure mice of several types of solid tumors, and identified which parasite proteins and which immunological pathways are required to break immune tolerance.

Unlike other solid tumors, there has been limited progress in understanding the contribution of genetic risk factors to the development of uveal melanoma, researchers say, primarily due to the absence of comprehensive genetic data from patients as the large sample cohorts for this rare cancer type have not been available for research.

Adds Liu: «With metastatic cancers accounting for around 90 % of deaths from solid tumors, the hope is that one day a device that can enable the analysis of single tumor cells circulating in the blood could make a big difference in early diagnosis, detection and monitoring of numerous types of cancer, without invasive biopsies.»

Although breast cancer was the initial focus and featured in the study published online today, the team has also conducted experiments with other types of solid tumors, with similar results.

«The CDK4 and 6 proteins are critical drivers of the cell - division cycle and are required for the formation and growth of various types of solid tumors,» says Dana - Farber's Shom Goel, MD, PhD, co-first author of the study with Molly DeCristo of the Hematology Division at BWH.

This discovery has implications for the understanding of glioblastoma as well as others types of solid tumors.»

Inclusion Criteria: • Availability of tumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion critumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion criTumor type specific exclusion criteria

She explores solid tumor analysis by NGS, explaining that annotation is directed at FDA - approved drugs in selected tumor types.

Single - cell DNA solid tumor profiling enables high resolution of the genomic diversity in a variety of tumor types.

Clinicians also conduct clinical research and three current, ongoing studies include investigations into canine osteosarcoma, the most common bone cancer in dogs; soft tissue sarcomas, the most common type of solid tumors in dogs; and feline fibrosarcoma, injection - site tumors in cats.

There is little solid data on the outcome of different tumor types because many dog owners do not have the necessary diagnostic testing performed to determine the exact type of tumor that afflicts their dog.

Seventeen years experience in Biotechnology and Pharmaceutical Sales * Multiple product launches in Biotechnology both in Solid and liquid tumor types * Proven ability to generate fresh ideas and implement creative customer focused solutions * Effective team leader excellent interpersonal communication and presentation skills * Experience in identifying market trends and developing the appropriate business plan * Selected t...