Sentences with phrase «somatic alterations»
"Somatic alterations" refers to changes or modifications that occur in the cells of an organism's body, other than in the reproductive cells. These alterations can include genetic mutations or modifications that may arise during a person's lifetime, resulting in differences between cells within the body. Full definition
David Chen «High - dimensional profiling of somatic alterations in homologous recombination - deficient cancer subgroups»
dartmouth.edu
To be also able to characterize the single cell genome and epigenome, we are developing new approaches for the identification of somatic alterations or open chromatin states.
The authors examined interactions between tumor proliferation levels (Ki67), histological categories, intrinsic subtype, and somatic alterations in these two categories of tumors.
Distribution of somatic alterations, each case is represented in a different color.
UNLABELLED: Cancer genome characterization efforts now provide an initial view of the somatic alterations in primary tumors.
In summary, this study sheds light on the somatic alteration landscape of ER - positive breast cancers and offers insight into some of the mechanisms of aromatase inhibitor resistance.
Contents: AML Sequencing • Capture Validation • Somatic Alterations • Mutation Profile • Evolution and Clonality • Convergent on IDH2 • Carl Zimmer Article • References Acute myeloid leukemia (AML) is a cancer of myeloid blood cells, in which abnormal white blood cells accumulate in the bone marrow and interfere with normal blood cell production.
A key advantage of whole - genome sequencing in cancer is that it captures the full scope of somatic alterations (from SNVs to large structural variants) throughout the genome.
To study these units of life CNAG has successfully established robust sequencing - based processes to quantify gene expression of thousands of single cells and we continue developing new approaches for the identification of somatic alterations and chromatin states in single cells.