Not exact matches
In a new study, Murphy, a molecular biologist at Princeton University, showed that long -
lived bodily, or
somatic,
cells in Caenorhabditis elegans, a one - millimeter nematode commonly used as a model for aging studies in labs, activate genetic pathways completely separate from those found in long -
lived egg, or oocyte,
cells.
The function of these genes were involved in molecular maintenance strategies, such as DNA repair, chromosomal maintenance, immune response and programmed
cell death The authors argue that the «slower rate of change in these functions is consistent with increased constraint on
somatic cell maintenance as would be required in these relatively long -
lived and large - bodied mammals, illustrated by the additional large and long -
lived species with slower rates in these genes (e.g. double - strand break repair gene XRCC4 is also highly constrained in elephant.»
So while unicellularity is clearly a successful way of
life for many organisms, for others the collective benefit of multicellularity appears to outweigh the loss of individual fitness for each
somatic cell that is denied a chance to pass on its particular genome.
The group, led by Hwang Woo Suk at Seoul National University, cloned human embryos using
somatic cell nuclear transfer, a process that biologists have used to clone
live animals.
With the
living evidence of Dolly, and other animals cloned from adult
cells, the idea that an adult
somatic cell could become a reprogrammed embryonic - like
cell regained a spotlight in the scientific community.
These specialized reproductive
cells — familiar to us as sperm and eggs in humans — set the stage for complex multicellular
life because they free up all the other
cells in the body (known as
somatic cells) to specialize for many other functions.
After mimicking stem
cell proteostasis in
somatic cells, his group found that these
cells live longer and are more protected from age - related diseases.
The Cas9 / gRNA - modified fibroblasts were subjected to nuclear reprogramming by
somatic cell nuclear transfer, resulting in
live - born goats carrying single - gene mutation.
The single - gene knockout fibroblasts were successfully used for
somatic cell nuclear transfer (SCNT) and resulted in
live - born goats harboring biallelic mutations.
Somatic cells acquire mutations throughout the course of an individual's
life.