Sentences with phrase «somatic mutation rates»

Not exact matches

Recent studies of somatic mutations in tumor cells revealed a fascinating phenomenon: a reduction in the mutation rate of highly transcribed regions, likely attributed to the fidelity conferred by transcription - coupled DNA repair mechanisms.

Cancers related to chronic mutagenic exposures, such as lung cancer (tobacco smoke) and cutaneous melanoma (UV radiation), have the highest rates of somatic mutations.

That's why it's possible to have a very high validation rate (> 90 %) for somatic mutations in solid tumors like lung cancer.

The six tumors with matched normal DNA harbored 15 somatic mutations on average (range 3 - 31), a mutation rate lower than adult GBM but higher than another pediatric brain tumor, medulloblastoma.

ii) HNPCC: germ line inactivation of one allele of either of the mismatch repair genes MSH2 or MLH1 in combination with somatic inactivation of the other allele leads to an increase in the mutation rate, which in turn speeds up the adenoma to carcinoma progression.