Sentences with phrase «somatic stem»

Adult stem cells — also called somatic stem cells — can be derived from the dog's own fat tissue and marrow.

Somatic stem cells, known as cyst progenitor cells, and differentiating cyst cells are labeled in red.

The strongest challenge to this approach, granting the periodic replenishment of somatic stem - cell pools with autologous but OncoSENS - ready stem cells, has been the possible existence of functions of TERT (telomerase reverse transcriptase — the catalytic subunit of telomerase), other than the lengthening of telomeres itself.

These cells are also called somatic stem cells.

In addition, the Garcia - Perez lab studies the impact of LINE - 1 retrotransposons in somatic stem cells and in Fanconi Anemia patients.

The collection of protocols includes the isolation and maintenance of stem cells from various species using «conventional» and novel methods, such as derivation of ES cells from single blastomeres, differentiation of stem cells into specific tissue types, isolation and maintenance of somatic stem cells, stem cell - specific techniques and approaches to tissue engineering using stem cell derivatives.

Through the screening of numerous natural ingredients based on the proliferative and migratory ability of the somatic stem cells, her team found several ingredients for the skin rejuvenation and launched skincare products with a concept of stem cell activation.

Pluripotent stem cellderived somatic stem cells as tool to study the role of microRNAs in early human neural development

MSCs are considered adult or somatic stem cells and remain in a non-proliferative, quiescent state during most of their lifetime, until stimulated by the signals triggered by tissue renewal, damage and remodeling processes.

«No one has ever studied protein synthesis in somatic stem cells.

The team did several experiments to be sure that the hub cells were involved, including one in which they genetically marked the hub cells and saw the mark appear in the newly formed somatic stem cells — a clear sign that hub cells had divided to make new stem cells.

But in the rest, the somatic stem cells grew back.

When the somatic stem cells were destroyed, the hub cells cranked up their machinery for cell division.

«When we finally figured out a way to kill all of the somatic stem cells, we thought that the rest of the tissue would probably just empty out,» she says.

According to Tomokatsu Ikawa, the first and corresponding author of the paper published in Stem Cell Reports, «We decided to look at the possibility that somatic stem cells could be maintained in a stem cell - like state where they could proliferate without undergoing differentiation.»

One key question to be answered is whether the barrier is established in all somatic stem cells of the body.

Not exact matches

If ESCR using «excess» embryos from IVE» continues, the next step will likely be the pursuit of such «therapeutic» cloning — the creation of embryos through somatic cell nuclear transfer (SCNT) to provide individually tailored stem cell therapies.

The study also found that in addition to its role in determining the sex of somatic cells, Sxl regulation by m6A is required to initiate germline stem cell differentiation for developing eggs.

In theory it is possible to transform either somatic cells (most cells of the body) or cells of the germline (such as sperm cells, ova, and their stem cell precursors).

In May 2013, Mitalipov was the first scientist in the world to demonstrate the successful use of somatic cell nuclear transfer, or SCNT, to produce human embryonic stem cells from an individual's skin cell.

Some can reproduce from outgrowths of stems, roots, and bulbs, but others are even more radical, able to create new embryos from single somatic cells.

More recently, researchers have induced stem cells from diseased human somatic cells, which may serve as new model systems for various illnesses.

There has been great interest in CRISPR - Cas9 as a tool to develop anticancer cell therapies or to correct genetic defects that cause hereditary in stem and somatic cells.

Stem cell researchers call them «a major step in the right direction,» although some were disappointed that NIH didn't open the door to the use of embryos created for research purposes — including through somatic cell nuclear transfer (cloning) and parthenogenesis (from an unfertilized egg).

Reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) provides a powerful tool for in vitro disease modeling and drug screening.

As «immature» somatic cells, stem cells can mature into different types of cells, thus making them responsible for the development of all the tissues and organs in the body.

Australian researchers have so far generated over 50 embryonic stem cell lines from surplus embryos, and three research groups have been licensed to attempt somatic cell nuclear transfer.

The creator of Dolly the sheep has ended his focus on somatic cell nuclear transfer, or cloning, in favor of another approach to create stem cells

His group began with 242 eggs, but after removing the eggs» nuclei and swapping in those of somatic cells, the investigators produced only 30 blastocysts (week - old embryos), from which they coaxed just one stem cell line into being.

As an alternative to harvesting them from embryos, scientists can also obtain pluripotent stem cells by treating mature somatic cells with a cocktail of transcription factors to regress them so that they are nearly as flexible as embryonic stem cells.

He reported in May 2013 using the Dolly technique, known more formally as somatic cell nuclear transfer, to derive stem cells from cloned human embryos, including from a baby with an inherited disorder.

The new finding brings a measure of closure to a story that first rocked the science world in February 2004, when Hwang and colleagues at Seoul National University announced they had cloned a female donor's cell by transferring its nucleus into one of her egg cells stripped of its nucleus in a procedure known as somatic cell nuclear transfer (SCNT), and harvested embryonic stem cells from the resulting fusion.

«Researchers are just now figuring out how adult somatic cells such as skin cells can be turned into embryonic stem cells.

Called induced pluripotent stem cells (iPSCs), these cells can be differentiated into any somatic cell type, making them a potentially valuable weapon against numerous diseases.

However, in a bid to figure out what happens when the somatic cyst stem cells are killed off, Matunis suggested that graduate student Phylis Hétié figure out how to best do away with them, thinking the task would be straightforward.

In a new Cell Reports paper, a team led by John P. Cooke, M.D., Ph.D., of the Houston Methodist Research Institute, has identified and characterized a biological factor critical to the transformation of adult somatic cells (cells that are not sperm or egg cells) into stem cells.

However, these problems associated with histocompatibility may be solved using autologous donor adult stem cells, therapeutic cloning, stem cell banks or more recently by reprogramming of somatic cells with defined factors (e.g. induced pluripotent stem cells).

Human embryonic stem cells derived from affected embryos during a pre-implantation diagnostic (PGD), as well as the conversion of somatic cells, such as skin fibroblasts, into induced pluripotent stem cells by genetic manipulation, offer the unique opportunity to have access to a large spectrum of disease - specific cell models.

Human pluripotent stem cells from two sources today, one physiological embryonic stem cells «ES» from the embryo, and the other experimental cells «iPS» induced pluripotency by reprogramming genetic somatic cells.

Comparisons of genetically matched human pluripotent stem cells reveals that somatic cell nuclear transfer is the ideal means of generating cells for replacement therapy

Disease - specific human pluripotent stem cells, from embryonic origin or derived from reprogramming somatic cells, offer the unique opportunity to have access to a large spectrum of disease - specific cell models.

This is hardly surprising, as the discovery, by Shinya Yamanaka, of the process to produce embryonic - like, fully pluripotent stem cells from ordinary somatic (body) cells has -LSB-...]

Prior to the advent of iPSCs in 2007 the only method researchers may have had to produce a genetically matched stem cell line from a patient's own cells was Somatic Cell Nuclear Transfer (SCNT), i.e., cloning.

Researchers have developed a new technique for creating human embryonic stem cells by fusing adult somatic cells with embryonic stem cells.

One of those teams created a cloned embryo from the somatic cells of a diabetic patient; this embryo was then destroyed in order to generate an insulin - producing embryonic stem cell line.

The second method used somatic cell nuclear transfer (cloning techniques) to exchange all the mtDNA from the patient's cells with normal mtDNA from an egg donor in order to derive embryonic stem cells that are patient - specific with respect to nuclear DNA, but «rescued» with respect to mtDNA.

He was also a Fulbright Scholar, and was part of the team that cloned the world's first human embryo, as well as the first to successfully generate stem cells from adults using somatic - cell nuclear transfer (therapeutic cloning).

By comparing the V. carteri germ and somatic cell transcriptomes, Matt and Umen found that the somatic cells had more transcripts from young, lineage - specific genes, whereas the germ cells had more transcripts from ancient genes that are similar to those expressed in stem cells from animals and land plants.

They included cloning (somatic cell nuclear transfer, accomplished in many placental mammals), stem cell gametogenesis (has been done in mice), direct engineering of early stage embryos (has been done in several mammals), embryonic stem cell editing, and primordial germ cell (PGC) editing.

STAP (stimulus - triggered acquisition of pluripotency) cells were thought to be engineered stem cells created when hematopoietic stem cells from the spleens of newborn mice were exposed to an acid environment, triggering their conversion from multipotent somatic cells to pluripotent - like stem cells.