Directed by Mark Pellington («Arlington Road,» «U2 3 - D») and written by first - timer Glenn Porter, «I Melt with You» stars Rob Lowe, Thomas Jane, Jeremy Piven and Christian McKay («Me and Orson Welles») as four smart yet deeply stupid 40 -
something college buddies who reunite for drug and booze - laden fun in Northern California's ultra-scenic Big Sur.