Not exact matches
«It's seen as a
memory condition but the first thing to go is
loss of
spatial orientation.»
Pathological hallmarks of AD, including plaques and
loss of synaptic markers, are readily apparent at nine months of age in huAPP / PS1 mice along with clear deficits in
spatial memory when compared to wild type controls [7, 10, 11, 31].
J147 prevented the
loss in
spatial working
memory, whereas donepezil did not.
We have previously shown ex-vivo its beneficial effect on synaptic transmission and plasticity in a mouse model of the OPHN1
loss of function.Here, we report that chronic treatment in adult mouse with Fasudil, is able to counteract vertical and horizontal hyperactivities, restores recognition
memory and limits the brain ventricular dilatation observed in Ophn1 - / y However, deficits in working and
spatial memories are partially or not rescued by the treatment.
«Warning signs are changes in mood or personality, withdrawal from work or social activities, decreased or poor judgment, misplacing things and losing the ability to retrace steps, new problems with words both in speaking and writing, trouble understanding visual or
spatial relationships, confusion with time or place, difficulty completing familiar tasks, challenge in planning or solving problems and
memory loss,» according to The Alzheimer's Association.
Research at the University of New South Wales suggests that high - sugar diets can lead to
memory loss — in fact rats fed a high sugar diet suffered deterioration in
memory and
spatial recognition in less than one week.
Yabut defined «peridementia» as the period in which the subject starts to have a mild version of the
loss of intellectual capacity that is associated with dementia — i.e., impairment of attention, orientation,
memory, judgment, language, motor and
spatial skills, and function.