Because stem cells can become bone, muscle, cartilage and other
specialized types of cells, they have the potential to treat many diseases, including Parkinson's, Alzheimer's, diabetes and cancer.
Its eyes have 16
specialized types of cells.
Our muscles are made of muscle cells, our livers of liver cells, and there are even very
specialized types of cells that make the enamel for our teeth or the clear lenses in our eyes!
The scientists note that certain
specialized types of cells in the liver could also have limited virus reproduction and put a damper on systemic inflammation and blood clotting problems in resistant mice.
«Absence of a transcription factor halts tooth development in mid-stride: Without the transcription factor Sp7, two
specialized types of cells that create dentin and enamel fail to mature.»
«We know that CEP63 depletion leads to problems during meiosis,
a specialized type of cell division that is required for male germ cells to produce sperm,» explains Stracker.
Normally, the cells Nobel used for the test would divide and give rise to
a specialized type of cell in the central nervous system called an oligodendrocyte.
In their new study, co-corresponding authors Wei Wang, PhD, professor in the departments of Chemistry and Biochemistry and Cellular and Molecular Medicine, and Gary S. Firestein, MD, professor in the Department of Medicine, investigated epigenetic patterns in fibroblast - like synoviocytes (FLS)--
a specialized type of cell that lines the inside of joints.
Chameleons change their colors using chromatophores,
a specialized type of cell that contains tiny sacs of pigments; when a chameleon shifts color, they do so by expanding or contracting these sacs to change the color of the cells.
Not exact matches
The researchers dialed the skin
cells back, developmentally speaking, to produce induced pluripotent stem
cells (iPSCs)-- a special
type of cell that can both self - renew, making more iPSCs, and differentiate,
specializing into almost any other
cell type.
These
cells, which can become several different
types of blood
cells, are similar to the
specialized stem
cells found in bone marrow that can churn out new blood
cells.
The back - and - forth attachment and removal
of methyl groups also fine - tunes gene expression in stem
cells, which can mature,
specialize and multiply to become muscle, bone, nerve, or other
cell types.
Duke University biologist Pelin Volkan and colleagues have identified a set
of genetic control switches that interact early in a fly's development to generate dozens
of types of olfactory neurons,
specialized nerve
cells for smell.
They concluded from that evidence that these
specialized RNAs were coming from two
types of epithelial
cells that line the GI tract.
Researchers have found that when properly enticed, some
types of specialized human
cells can revert to a more nascent state (see p. 85).
Tfh
cells are a
type of CD4 + T helper
cells specialized in providing help to B
cells, which are the
cells that make antibodies.
Researchers also plan to modify the genetic set up
of induced pluripotent stem
cells (iPS), which can be differentiated into
specialized cell types or tissues.
Using an animal model, the UAB researchers found that a lack
of Sp7 interrupts the maturation
of two
types of specialized cells that help create teeth.
In a second study, they applied CellNet's teachings to a recurring question in stem
cell biology: Is it feasible to directly convert one
specialized cell type to another, bypassing the laborious process
of first creating an iPS
cell?
«Most attempts to directly convert one
specialized cell type to another have depended on a trial and error approach,» notes Cahan, principle architect
of CellNet and a post-doctoral scientist in the Daley lab.
However, two
types of cells in the olfactory epithelium (
specialized tissue responsible for sense
of smell), are mixed together and form a mosaic pattern despite expressing different
types of cadherins.
Each
of these onion - shaped sensory structures contains several different
types and subtypes
of taste receptor
cells, each with a
specialized function.
Adult stem
cells: They have less flexibility and «stemness» to change into different
cell types, but they can still produce new
cells,
specialized to become part
of a particular organ or tissue, such as muscle
cells or neural
cells.
This is one
of the first studies to show that a
specialized cell type that was thought to be at the end
of its ability to differentiate can revert to an earlier state under the right conditions.
Earlier mouse studies by Li and his collaborators had indicated that the expression
of several imprinted genes changes as hematopoietic stem
cells embark on their journey from quiescent reserve
cells to multi-lineage progenitor
cells, which form the many highly
specialized cell types that circulate within the blood stream.
Isolated and grown from the patients» fat, these
specialized cells have the potential to develop into several different
types of tissue.
The current study revealed that amlexanox exerts its effects through a
specialized type of fat
cell by increasing the level
of a second messenger molecule called cAMP.
Understanding this
specialized chromatin «ground state» has the potential to provide insights into the yet mysterious process
of epigenetic reprogramming to totipotency, the ability to give rise to all
cell types.
It has billions
of parts, many used to activate and silence genes — an arrangement that allows individual
cells to
specialize as brain
cells, heart
cells and some 200 other different
cell types.
«Now we can take easy to obtain blood samples, and make the main
cell types of neurological systems — the central nervous system and the peripheral nervous system — in a dish that is
specialized for each patient,» said Bhatia.
In the breast, the ducts designed to carry milk during and after pregnancy are composed
of two highly
specialized cell types and a niche
of stem
cells that gives rise to both
types.
Studying a new
type of pinhead - size, lab - grown brain made with technology first suggested by three high school students, Johns Hopkins researchers have confirmed a key way in which Zika virus causes microcephaly and other damage in fetal brains: by infecting
specialized stem
cells that build its outer layer, the cortex.
Neural crest
cells are a
type of stem
cell; during vertebrate embryonic development, they eventually differentiate into
specialized cells such as those that make facial skeleton
cells or those that create pigment
cells.
The 10 - millimeter long robot is made up
of four layers: tissue composed
of live heart
cells, two distinct
types of specialized biomaterials for structural support, and flexible electrodes.
When a stem
cell divides, each new
cell has the potential either to remain a stem
cell or become another
type of cell with a more
specialized function, such as a muscle
cell, a red blood
cell, or a brain
cell (Fig 1).
Immunological Invisibility Cloak Among them is Joel Linden, Ph.D., who recently reported that jamming signals transmitted by membrane proteins called adenosine receptors, which are expressed on T
cells and on
specialized cell - killing
cells called NK
cells, made both
cell types more effective in halting lung metastasis
of melanoma
cells.
He plans to figure out how and if the sequence
of developmental signals directs embryonic stem
cells to transform into more
specialized cell types.
Kriegstein said the identification
of hundreds
of novel biomarkers for diverse
cell types will improve scientists» understanding
of the emergence
of specialized neuronal subtypes.
The gene, known as gata5, acts in embryonic
cells, which are primordial, unspecialized
cells that form in the earliest stage
of embryonic development and are genetically programmed to evolve into one
of many
specialized cell types, such as skeletal muscle
cells, nerve
cells, blood
cells, skin
cells, and liver
cells.
Current efforts, mostly conducted in animal models, involve attempting to derive and aggregate embryonic stem
cells, exposing them to such factors as acetic acid, allowing them to differentiate, or
specialize, and then sorting through these
cells to extract the
cell types of interest.
Differentiation
of a
cell into a more
specialized cell type is directed by cellular circuits.
We offer defined and xeno - free laminin
cell culture matrices for reliable expansion
of pluripotent
cell and differentiation and maintenance
of specialized cell types
The ability
of adult stem
cells to divide and generate both new stem
cells (called self - renewal) as well as
specialized cell types (called differentiation) is the key to maintaining healthy tissues.
Unlike other
cell types, stem
cells are unspecialized
cells uniquely capable
of making copies
of themselves (self - renewing), differentiating into
specialized cell types, and helping to maintain some tissues in the human body.
When a stem
cell divides, it has the potential to either remain as a stem
cell (process known as «self - renewal») or to become a different
type of cell with a more
specialized function («differentiation»).
The most interesting aspect
of the study, say the authors, is the discovery
of a new,
specialized function
of a certain
type of regulatory T
cell, which is to enable microbes to play useful roles by keeping them from causing inflammation.
Stem
cells are undifferentiated
cells which have the potential to develop into many different
types of specialized tissues.
Luckily, different
cell types tend to have different things on their surfaces, which play particular parts in their
specialized roles in the tissue, so it is a matter
of identifying and targeting
cell - surface markers that are specific to these abnormal
cell types.
Neuronal progenitor
cells resemble stem
cells in that they have the ability to
specialize into different
cell types, though with a more limited range
of differentiation.
Multicellular organisms like plants and animals are complex co-operative structures made
of many
specialized cell types, while a single yeast
cell can survive and proliferate without the help
of others.