Sentences with phrase «specific ctl»

TCR analyses show that CMV - specific CTL have highly restricted clonality with greater restriction in the larger expansions.

In this study, we show that in elderly individuals seropositivity for human CMV leads to the development of oligoclonal populations of CMV - specific CTL that can constitute up to one - quarter of the total CD8 T cell population.

Furthermore, CMV - specific CTL have a highly polarized membrane phenotype that is typical of effector memory cells (CD28 -LRB--), CD57 (+), CCR7 -LRB--)-RRB-.

Such virus variants selectively suppress LCMV - specific CTL responses and cause persistent infections in immunocompetent mice.

Our results show that LCMV variants that emerge during infection in vivo play a crucial role in the suppression of virus - specific CTL responses and in the maintenance of virus persistence.

Using adoptive transfer experiments we found that spleen cells from persistently infected (carrier) mice actively suppressed the expected LCMV - specific CTL response of spleen cells from normal adult mice.

The transfer of spleen or lymph node cells containing LCMV - specific CTL resulted in virus clearance and prevented establishment of the carrier state.

The suppression of LCMV - specific CTL responses by carrier spleen cells is not mediated by a suppressor cell, but is due to the presence of genetic variants of LCMV in spleens of carrier mice.

(PMID: 9545200) Dunbar PR, Chen JL, Chao D, Rust N, Teisserenc H, Ogg GS, Romero P, Weynants P, Cerundolo V. Cutting edge: rapid cloning of tumor - specific CTL suitable for adoptive immunotherapy of melanoma.

While the individual effects of the drugs on virus - specific CTL differ somewhat depending on specific assays, schedules, and doses, treatment with any of the three HDAC inhibitors impaired the ability of CTL to kill HIV - infected immune cells.

In collaboration with Pedro Romero, Vincenzo Cerundolo and colleagues demonstrate that, unlike virus - specific CTLs, the highest frequency of tumor - specific CTLs can be found in tumor - infiltrated lymph nodes.

HIV - 1 — specific CTLs have an unusual phenotype and are low in perforin [15, 16, 43], and it has been suggested that progressive loss of CD4 + cell help may be important.

Not exact matches

In our study, CD8 − T cells from CD4 KO rejector mice failed to display CTL or DTH activity, yet they were capable of inducing donor - specific apoptosis of corneal endothelial cells.

The laboratory of Vincenzo Cerundolo is the first group to report the use of tetrameric soluble class I / peptide complexes (tetramers) for the identification of tumor - specific cytotoxic T lymphocytes (CTLs), and subsequently shows that these novel reagents allow rapid and accurate analysis of human CTL responses.

The suppression was specific for the CTL response and LCMV - specific antibody responses were not affected.

Although we believe our approaches have broad potential across multiple therapeutic areas, we are focused in oncology and have engineered our technologies to activate the immune system's natural ability to create tumor - specific cytotoxic T cells, or CTLs, to fight cancer.

These approaches are designed to generate strong, tumor - specific cytotoxic T lymphocytes (CTLs) and attempt to overcome shortcomings of other approaches.

Although they have distinct mechanisms of action, the lead agents from both platforms — CMB305 and G100 — where designed to convert «cold» tumors, or those without CTLs, to «hot» tumors, or those with CTLs specific for the antigens expressed by the tumor.

Such a dramatic accumulation of virus - specific effector CTL might impair the ability to respond to heterologous infection and may underlie the negative influence of CMV seropositivity on survival in the very elderly.

They do, however, play a key role in helping to boost the anti-tumor immune response by: (1) expanding the number and improving the function of existing CTLs that are specific to the same tumor antigen; and (2) providing help to other immune cells, including B lymphocytes that are precursors to antibodies and natural killer (NK) cells that are also important in the overall anti-tumor immune response.

ZVex ® and GLAAS ™ are our complementary discovery platforms designed to activate and expand the immune system's natural ability to create tumor - specific cytotoxic T cells (CTLs) in vivo.

Similar to CTLs, these CD4 T cells will be specific to a tumor antigen, but unlike CTLs, they generally can not kill antigen - bearing tumor cells.

This process activates the CD8 T cell and causes it to divide, creating millions of CTLs to kill tumor cells that bear that specific tumor antigen, including neoantigens.

We believe DCs are the most important immune cells to target because they initiate the specific immune response that generates CTLs to kill the tumor.

(D) H - 2d - specific allo - CTL lines were established from splenic CD8 - SP cells, and CTL assay was analyzed for CTL function by using specific (P815) and nonspecific (EL4).