Sentences with phrase «specific adaptive immune response»

When accompanied by an antigen in protein form, generation of a strong, antigen - specific adaptive immune response characterized by CD4 T cells.

Not exact matches

The UNC research team, led by Lemon and Jason Whitmire, Ph.D., Associate Professor in UNC's Department of Genetics, is now poised to investigate the complicated interplay of nonspecific «innate» and specific «adaptive» immune responses that ultimately control the infection and eliminate HAV from the host — processes that are not well understood for any of the five human hepatitis viruses.

They serve to contain viral infections while the adaptive immune response is generating antigen - specific cytotoxic T cells that can clear the infection.

Following transmission by mosquitoes, the early specific (also called adaptive) immune response to WNV is thought to be dominated by antibodies, and, consistent with this, the researchers found that older mice had less potent WNV - specific antibody responses during the early phase of infection.

Adaptive immune responses are initiated by the clonal selection of naive T lymphocytes, which recognize their cognate ligands through antigen - specific T cell receptors.

The group also has experience in the creation of custom panels for the analysis of pathogen specific immune responses with focus on innate and adaptive arms of the immune system.

Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.