Sentences with phrase «specific animal model»

Please contact one of our scientists for references pertaining to your specific animal model.

Since olfactory sensory neurons regenerate throughout life, even in humans, the investigators were able to measure neuron regeneration in specific animal models.

The CRISPR - Cas technology generates specific animal models of disease and is transforming model generation in mice, rats, rabbits, and larger animals.

Not exact matches

Strategies that boost the cell's quality control programs, rather than disarm specific pathologic proteins, have looked promising in lab animals that serve as models for human neurodegenerative disorders including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.

To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.

Now, the researchers have discovered an alternative in a mouse model: in the case of breast tumours with a specific defect in DNA repair, the animals can be cured using already established, cheap chemotherapy drugs, if enough DNA damage can be inflicted on the resting tumour cells.

And the trouble with extrapolating so much from mouse studies is that «nobody has actually shown over the long term how long these quote un-quote improvements persist, and we don't know whether it's broadly improving aspects of aging or it's specific to certain tissues,» said Matt Kaeberlein, a biologist who studies aging in dogs and other animal models at the University of Washington.

In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.

However, it was unclear at this stage in their research if this was a species - specific finding limited to animal tumor models or if this was a biologic phenomenon that may also be present in cancer patients.

Importantly, these devices also will open up new approaches to drug development not possible with animal models today, such as personalized medicines and development of therapeutics for specific genetic subpopulations using chips created using cells from particular patients.»

The use of cell surface markers to isolate specific cell populations is one common method for separating cells; however, isolating live cells based on their RNA expression is a powerful new way enabling the study of small cell niches in nongenetically modified animal models and human tissue.

The engineered T cells also performed successfully in a mouse model of PV, killing desmoglein - specific B cells and preventing blistering and other manifestations of autoimmunity in the animals.

Using an animal model, they found that TIMP - 1 recruits immune cells by increasing the levels of a specific signaling molecule in the liver.

No previous studies have investigated the direct effect of sugar consumption on the development of breast cancer using breast cancer animal models or examined specific mechanisms, she added.

The researchers» strategy — generating disease - specific nerve cells, identifying a causative gene for developmental defects, validating the gene - specific defect in animal models, and then investigating interactions with other genes both in animal models and in humans — represents a promising new approach for understanding the mechanisms underlying some of the most intractable psychiatric illnesses.

Our scientific team works closely with our Clients to develop new animal models, new procedures and assays as required by specific projects.

For this purposes animal models and specific coculture systems have been developed.

Scientists from the LoGrasso lab have been able to show in animal models that inhibiting a specific enzyme protects heart cells and surrounding tissue against serious damage from heart attacks.

Other animal models either express oncogenes in a tissue - specific manner or shut down the expression of tumor suppressor genes in the whole tissue.

The comprehensive information presented for each cell therapy includes: an overview of the therapy, a list of therapeutic cells utilized in the specific treatment, mode and regimen of cell delivery, mechanism of action, formulation, in vitro data, animal models, preclinical data and related clinical trials.

These exosomes contain specific microRNAs that promote myelination of aging brain as well as brain damaged by multiple sclerosis modeled in animal brain tissues.

Having previously published data on a variety of experimental mAbs against AS species in animal models -LRB-[16,20]; possibly [21]-RRB-, Prothena's Dale Schenk presented new data on additional experimental antibodies at SENS Research Foundation's Rejuvenation Biotechnology 2014 conference, roughly contemporaneous to its publication, [22] along with information specific to the humanized candidate PRX002, which is now being advanced into clinical trials.

Each cell - based treatment approach is presented as a potential therapy for a specific disease or a disease category (e.g.: cardiovascular diseases, metabolic diseases, etc.), studied in animal models or in humans.

«We discovered that a specific protein, thrombospondin - 2 (TSP2), is elevated in wounds of patients with diabetes as well as in animal models of diabetes,» said Britta Kunkemoeller, a doctoral student at Yale University who conducted the study.

These trials from WAVE are slightly unique, because the company has not conducted studies in HD animal models with their specific drugs.

Despite a large number of sex - specific gametogenesis proteins uncovered in the model organisms Drosophila, C. elegans and mice, no conserved male - or female - specific gametogenic factors common to all lineages of animals have been clearly demonstrated [30]--[33].

Making use of cell and animal models, my laboratory group addresses some of the fundamental questions of how ethanol exposure injures the liver, with a goal ofidentifying the individual targets of ethanol - induced injury and the specific responses of the key cell types within the liver, as well as the integrated, organismal response to this ethanol - induced injury.

As one of the three initial cores established when the Buck Institute was founded, the Genomics Core has played a vital role in helping shape investigations in the basic molecular biology of aging, from assisting in the investigation of how specific drugs can extend lifespan in simple model organisms such as the nematode C. elegans, to facilitating studies in various animal models of age - related disease.

With an animal model that replicates at least some aspects of OCD, researchers can dig deeper into the specific neurotransmitters and systems involved in the disorder.

No previous studies have investigated the direct effect of sugar consumption on the development of breast cancer using breast cancer animal models or examined specific mechanisms, she added.

«The dog and cat industry has long served as a model of how to provide support for animals throughout all stages and challenges of life,» says Lucas Stock, communications manager at Oxbow Animal Health based in Omaha, Neb. «Knowledge and education regarding the longevity and specific health needs of small animals has evolved considerably in recent decades and across all sectors.»

However, rather than traditional floral and geometric motifs, these vases boast modern hieroglyphs of Mexican and Norteño drug culture - marijuana leaves, guns, skulls, pin - up models, bottles of liquor, packs of cigarettes, and animals that symbolize specific drugs: the rooster, marijuana; the goat, heroin; and the parrot, cocaine.

Opening: «Eduardo Sarabia: Ballads» at Other Criteria Combining decorative art objects with motifs referencing the Mexican and Mexican - American drug scene — ranging from guns, skulls, and nude pin - up models to marijuana leaves and animals symbolizing specific illegal drugs — Eduardo Sarabia makes art from Narco culture.

The composite model, which implements Google's TensorFlow neural network processing as well as models such as Pascal and Cityscapes, essentially determines what items in the image are classified as human, animal, food or some other genre as well as define specific ranges for these items.

(See sociocultural systems model) Species specific — A phenomenon that is unique to a given species of animal, and to only that species.