It builds on a 2011 discovery by Berman and Laird that first determined loss of these DNA marks — called methyl groups — occurs in
specific areas of the genome in cancer.
Researchers have previously harnessed this system to create gene - editing complexes composed of a DNA - cutting enzyme called Cas9 and a short RNA that guides the enzyme to
a specific area of the genome, directing Cas9 where to make its cut.
According to Dr. Burgess, the team is now working to extend the period that sperm cells can be cultured, so there is more time to select cells that have the foreign gene inserted in
specific areas of the genome in what is commonly called a «targeted gene knockout.»
Not exact matches
These regions can be clumped into larger
areas of the
genome called quantitative trait loci, which are known to contain genes that produce a
specific physical effect, such as shaggy hair.
They found four key
areas of the
genome where
specific SNPs correlate with skin color.
The locus sits close to an
area of the
genome where humans and chimps are known to share
specific combinations
of genes.
Scientific working groups will drive forward
specific areas of analysis including statistics and population genetics (led by Gil McVean and Roberto Amato), technology benchmarking (led by Dan Neafsey and Jim Stalker) and reference
genomes (led by Matt Berriman and Thomas Otto).
An international speaking panel will bring together top researchers in the
areas of genome wide scanning (GWS), the major histocompatability complex (MHC), genetic testing, genetic counseling, and
specific genetic disorders
of cats and dogs.