By utilizing the tools of cell and molecular biology, he studies the mechanisms by which chemical (for example,
specific cell adhesion molecules) or mechanical signals (for example, cyclic strain) are sensed by cells and alter their proliferation and specialization to either promote tissue growth or destruction.
Not exact matches
This drug (vedolizumab) blocks a
specific adhesion molecule on the surface of the T -
cell and thereby inhibits immune
cells from binding themselves to receptors present in the intestine, preventing the T -
cells from penetrating the blood vessels in the intestinal tissue.
Research groups in Munich, Essen, and Brussels have now detected a highly
specific and exceptionally strong variant of this
adhesion, in which the bacterial surface molecule HopQ binds itself to so - called «Carcinoembryonic Antigen - Related Cell Adhesion Molecules,» or CEACAMs for short, inside the
adhesion, in which the bacterial surface
molecule HopQ binds itself to so - called «Carcinoembryonic Antigen - Related
Cell Adhesion Molecules,» or CEACAMs for short, inside the
Adhesion Molecules,» or CEACAMs for short, inside the stomach.
Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes
adhesion molecules, a class of
cell surface proteins that function in the interactions of immune
cells with other
cells, including antigen -
specific recognition and
cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular
adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune disease.
Endothelial
cell specific adhesion molecule (ESAM) localizes to platelet — platelet contacts and regulates thrombus formation in vivo.