Sentences with phrase «specific cell fate»

The pathway that it takes decides in which valley it will finally settle, providing a metaphor for the acquisition of a specific cell fate.

These workers considered that this fluctuation might account for reversible lineage priming towards specific cell fates.

Not exact matches

The two - part approach netted a set of mutations seen only at relapse that enabled the team to sift and sort leukemic and normal stem cells using tools developed in the Dick lab a few years ago to zero in on specific cell types fated to relapse.

By monitoring stem cell differentiation on gels that mimic the stiffness and nanofibrous structure of biological tissue, researchers have identified the specific molecules that stem cells use when selecting bone and cartilage fates.

Her research team placed the evolutionarily conserved castor (Cas) gene, which encodes a zinc finger protein, in a genetic circuit with two other evolutionarily conserved genes, hedgehog (Hh) and eyes absent (Eya), to determine the fates of specific cell progeny (daughters).

The expression of specific genes in a particular root cell determine its fate — the zone in which it will function, Subramanian explained, so he is identifying which micro-RNAs direct gene expression to achieve this differentiation.

It will be interesting to determine if specific EFTF subsets can fate pluripotent cells to other (nonretinal) neural lineages.

Each cell fate is characterized by a regulatory network of factors, typically transcription factors that maintain a specific state through reciprocal feedback interactions.

A better understanding of this master switch regulator may help to understand, how cells that have a common origin take on a specific fate in the body to build an organ and may also help to understand the development of certain leukemias.

Found that muscle - specific histone methyltransferases and microRNAs regulate the activity of Hand2, a transcription factor essential for ventricle formation and more recently showed that microRNAs can efficiently guide stem cell fate decisions.

In doing so, specific cell types may activate immune responses to fine tune cell - fate decisions at the organismal level; for instance, DNA damage in germ cells induces an innate immune response in worms that promotes endurance of somatic tissues to allow delay of progeny production when germ cells are hit by DNA damage.

Because the embryo is transparent it is possible to use fluorescent proteins to label specific cells and their components, and then use this to watch the fate of the cells in the presence or absence of different genes.

Both human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) can colonize the mouse embryo in a manner predicted from classical developmental fate mapping and faithfully recapitulate tissue - specific fate post-transplantation.

Our findings suggest that pluripotency is determined by the capacity of a mixed population of lineage - biased intermediates to commit to different cell fates in specific contexts.