Sentences with phrase «specific cell population»

As a result, the mice developed significantly increased numbers of a specific cell population in the blood, which the researchers characterized as MDSCs.

However, another report found that miR - 7 expression correlated with poorer prognosis of breast cancer, and these apparently conflicting results suggest that miR - 7 may be differentially expressed in a specific cell population of breast cancer (26).

Techniques enabling the isolation of specific cell populations have advanced our ability to identify and characterize niche cell types which may be used to replace or engineer cells / tissue.

The use of cell surface markers to isolate specific cell populations is one common method for separating cells; however, isolating live cells based on their RNA expression is a powerful new way enabling the study of small cell niches in nongenetically modified animal models and human tissue.

In a Nature paper introducing the optogenetic tool, Konermann and Zhang showed they could package LITEs in viral vectors and genetically target them to specific cell populations.

T - DDOGs also successfully regulated expression of channelrhodopsin - 2, commonly used in optogenetics, opening up the possibility of adapting GFP lines for optogenetics experiments in specific cell populations.

Cre - DOG is also suitable for optogenetic studies, and since cells infected with AAV - Cre - DOG retain normal neuronal function, this system may make optogenetics in specific cell populations even easier.

These cells were detected in the peripheral region of the EBs as specific cell populations, such as SSEA1 - positive, OCT -4-positive cells, OCT -4-positive, VASA - positive cells, and OCT -4-negative, VASA - positive cells.

Not exact matches

Scientists could build chips containing cells from patients with specific genetic mutations, which could predict drug responses in specific populations, as well as personalized chips that predict an individual's drug response.

Neuroscientists at Cold Spring Harbor Laboratory (CSHL) have mobilized advanced imaging and computational methods to comprehensively map — «count» — the total populations of specific types of cells throughout the mouse brain.

They demonstrated that non-obese diabetic (NOD) mice treated with a specific (AID / RAD51) pathway inhibitor had larger populations of certain B cells that were capable of suppressing diabetogenic T cell responses, and greatly reduced T1D development, compared with untreated controls.

In this study, the researchers found that a specific population of immune cells called macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin - 10 (IL - 10), which can interact with receptors on intestinal epithelial cells to promote wound healing.

He then evaluated the levels of specific microRNAs in populations of highly metastatic, compared to poorly metastatic, cancer cells taken from the same patient.

PCC 7942) and observed marked differences in the levels of specific complexes in cell populations that were grown under nitrogen - depleted conditions.

By varying the compositions of lipids, cues, and diffusible factors in the scaffolds, we engineered a very versatile and flexible platform that can be used to amplify specific T cell populations from blood samples, and that could be deployed in existing therapies such as CAR - T cell therapies,» said Mooney, Ph.D., a Core Faculty member at the Wyss Institute and leader of its Immunomaterials Platform.

Led by Matthew P. Anderson, MD, PhD, Director of Neuropathology at BIDMC, the scientists determined how a gene linked to one common form of autism works in a specific population of brain cells to impair sociability.

Researchers take advantage of this feature to obtain populations of synchronized bacteria that can be used to study specific cell cycle processes.

A couple of other research groups have also sorted stem cells based on gene expression, but they have not done so specifically with the goal of enriching cell populations for a specific tissue, the researchers said.

The code that a monkey's brain uses to represent faces relies not on groups of nerve cells tuned to specific faces — as has been previously proposed — but on a population of about 200 cells that code for different sets of facial characteristics.

In the different cell types, the loops begin and end at different specific chromosomal locations, so each cell line's genome appears to have a unique population of loops.

So I [thought], I know a little bit of immunology, I know a little bit of engineering, and I really want to talk about developing systems that can modulate antigen presentation or expand T cell populations in a specific direction.

«For the broad application of stem cell - derived pituitary cells in the future, cell replacement therapy may need to be customized to the specific needs of a given patient population,» Zimmer says.

A new study in Nature Genetics identifies a specific population of pluripotent embryonic stem cells that can reprogram to totipotent - like cells in culture.

When coexpressed with a recombinase, these intracellularly expressed ssDNAs target specific genomic DNA addresses, resulting in precise mutations that accumulate in cell populations as a function of the magnitude and duration of the inputs.

From these three cell populations different functional tissue cells arise, such as skin cells, muscle cells, and specific organ cells.

Dr. Angulo and his team plan to expand on their findings about this specific patient population by examining data beyond BMI, including fat distribution and differences in cell signaling proteins, such as cytokine and adipokine profiles.

These proteins are crucial for tissue healing by instructing various processes, including the activation of specific stem cell populations, ensuring that lung tissue can be restored to its original condition.

A Ludwig Cancer Research study published online September 14th in Nature reports a novel technique to map specific chemical (or «epigenetic») modifications made to the protein packaging of DNA using a small population of cells.

In this report, we found that CSCs (CD24 − / CD44 + / ESA +) isolated from metastatic breast cell lines are significantly more metastatic than non-CSC populations in an organ - specific manner.

The scientists then stained the embryo with specific markers to identify cell populations.

Dr. Cui's research concluded that the cancer resistance was mediated by a specific population of leukocytes (granulocytes and monocytes) and that these cells, when transfused to a mouse with cancer, would cure the cancer.

This two - volume reference integrates this exciting area of biology, combining the prerequisites for a general understanding of adult and embryonic stem cells, the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations, as well as a presentation by the world's experts of what is currently known about each specific organ system.

Cell markers are helpful tools used to identify a specific immune cell populatCell markers are helpful tools used to identify a specific immune cell populatcell population.

With Dr. Bill Carlezon, Dr. McCullough is investigating the cell - type specific contributions of neuron populations within the nucleus accumbens to stress related pathologies.

They are the only means to target and manipulate specific cell types (populations) within neuronal networks in living animals.

The researchers found that a specific stem / progenitor cell population was inhibited following radiation in mice missing Nrf2, and that alveolar type 2 cells in these mice were more likely to change into myofibroblasts — a cell type implicated in fibrosis.

As part of this global aim we have demonstrated that one of the most abundant stromal populations, the cancer associated fibroblasts (CAFs), can sample and present tumour antigen to T cells in an antigen specific - antigen dependent manner resulting in T cell deletion.

Such performance - enhancing alterations will include reprogramming using non-integrating vectors or small molecules, the identification of the specific cell within the CS populations which provides therapeutic benefit, and the long - term consequences of CS cell transplantation.

We identify a population of mesodermal cells in a developing invertebrate, the marine annelid Platynereis dumerilii, that converges and extends toward the midline and expresses a notochord - specific combination of genes.

This may be relevant for understanding the evolution of the large human CMV - specific CD8 + T cell populations seen in humans.

However, with few exceptions, the stem cell and regenerative medicine industry has remained inadequately capitalized to carry out large - scale clinical trials independently, and major pharmaceutical firms have tended to show more interest in the use of hiPSCs as a source of large, pure populations of specific somatic cells for use in drug compound screening and toxicology tests, than they have in therapeutic uses of stem cells and their derivatives.

In this study, we show that in elderly individuals seropositivity for human CMV leads to the development of oligoclonal populations of CMV - specific CTL that can constitute up to one - quarter of the total CD8 T cell population.

Upon transfer of aged donor CD4 T cells to young hosts, there was significantly reduced expansion and germinal center (GC) differentiation of the antigen - specific B cell population after immunization.

To define the phenotype and function of specific cellular populations involved in the cross-talk between cancer and immune cells we make use of both flow - cytometry and mass - cytometry.

Senescence is a specific physiological stage of cells characterized by long population doubling time.

Janbazian L, Price DA, Canderan G, Filali - Mouhim A, Asher TE, Ambrozak DR, Scheinberg P, Boulassel MR, Routy JP, Koup RA, Douek DC, Sekaly RP, Trautmann L. Clonotype and repertoire changes drive the functional improvement of HIV - specific CD8 T cell populations under conditions of limited antigenic stimulation.

Through long - established collaborations in Durban and Kimberley, these studies in particular seek to define: the immune responses that are effective in control of HIV infection; the impact of HLA - mediated selection pressure on HIV at the individual and population level; the mechanisms of HIV non-pathogenicity; the nature and consequences of ontogeny of the virus - specific immune response; and finally the prospects for interventions including antiretroviral therapy, alone or in combination with broadly neutralising antibodies and / or T - cell vaccines, to achieve HIV eradication.

Our tool thus allows users with biological knowledge to study the possible effects that their set of SNPs might have on these genes and predict their cell - specific expression levels relative to the population.

Our findings suggest that pluripotency is determined by the capacity of a mixed population of lineage - biased intermediates to commit to different cell fates in specific contexts.

We found that CMV - specific CD4 + T cells were significantly expanded in healthy young and old carriers compared with purified protein derivative -, varicella zoster virus -, EBV -, and HSV - specific populations.