Sentences with phrase «specific cell sites»

They drip, if you will, into the bloodstream where they travel to the distant tissues and organs, where they then bind to the tissues» and organs» specific cell sites called receptors.

Not exact matches

Called SIF - seq, for site - specific integration fluorescence - activated cell sorting followed by sequencing, this new technique complements existing genomic tools, such as ChIP - seq (chromatin immunoprecipitation followed by sequencing), and offers some additional benefits.

Site - specific administration of chemokines (CXCL9 - 10) restored homing signals that were diminished in septic hosts to permit recruitment of effector cells to the skin.

«Unlike previous studies we isolated different immune cell types from the actual site of disease to determine whether specific subsets of immune cells (specific T cell groups) have equal sensitivity to vitamin D.»

Morphine and its derivatives seem to exert their effects by binding to specific receptor sites on cells in the brain and the spinal cord.

«It seems like the whole Drosophila community is switching over to ΦC31 because it's both more efficient and its 100 percent site specific,» notes Michele Calos, a geneticist at Stanford University who is a pioneer in work on the ΦC31 integration scheme in mammalian cells.

HCV invades cells in the body by binding to specific receptors on the cell, enabling the virus to enter it.2 Once inside, HCV hijacks functions of the cell known as transcription, translation and replication, which enables HCV to make copies of its viral genome and proteins, allowing the virus to spread to other sites of the body.2 When HCV enters the host cell, it releases viral (+) RNA that is transcribed by viral RNA replicase into viral -LRB--) RNA, which can be used as a template for viral genome replication to produce more (+) RNA or for viral protein synthesis.

The authors report that their findings represent the first demonstration of a functional link between changes in T cell activation and targeting of specific integration sites by HIV - 1.

Antibody responses are initiated in lymph nodes close to the site of initial infection (so - called draining lymph nodes, or DLNs), where antigen - presenting cells, helper T cells, and antibody - producing B cells migrate to and interact to form so - called «germinal centers» and produce a highly specific antibody response.

Short DNA sequences known as «PAM» (shown in yellow) enable the bacterial enzyme Cas9 to identify and degrade foreign DNA, as well as induce site - specific genetic changes in animal and plant cells.

This enabled them to build an atlas of specific binding sites within the context of whole cells.

Receptors are proteins that are usually located on the external surface of the cell membrane; they provide specific recognition sites for messenger substances such as hormones, neurotransmitters and growth factors.

Site - specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.

Current understanding of Bcl - xL's structure describes a protein with three regions — a core that interacts with proteins involved in cell death, a flexible region lacking defined structure (IDR) with an unknown function, and a membrane - anchoring region that attaches the protein to specific sites within the cell.

So instead of taking a shotgun approach to killing a cancer cell, we are using a targeted approach that is not necessarily specific to an anatomical site, but rather the specific mutation identified in the tumor.

In this context, the Lingwood laboratory studies B cell antibody responses to both HIV and influenza with the goal of 1) understanding how antigenic sites of vulnerability are initially perceived by specific germline B cell receptor (BCR) sequences and 2) how that recognition process can direct antibody affinity maturation toward production of broadly neutralizing anti-viral responses.

They determined that altering the expression level of LIGHT (a specific type of molecule that binds to a receptor site of another cell) and also lymphotoxin (LT) on T cells significantly impacted the cholesterol and triglyceride levels.

Programmable nucleases, ZFN, TALEN and RGENs enable gene knockout in cultured cells and organisms by producing site - specific DNA double - strand breaks, whose repair via error - prone non-homologous end joining (NHEJ) or microhomology - mediated end joining (MMEJ) gives rise to frameshift mutations.

The stem cells must be safely implanted into the correct site within the eye and, in order to be functional, must establish working connections with specific parts of the brain.

Berkeley Lab's Len Pennacchio (left) and Axel Visel led the development of a new technique for identifying gene enhancers called SIF - seq, for site - specific integration fluorescence - activated cell sorting followed by sequencing.

CRISPR / Cas9 can also deliver the CAR gene to a very specific site within the T cell genome, which may reduce the risk of gene insertion at incorrect or undesired locations.

We have recently developed the use of site - specific nucleases to genetically engineer human pluripotent stem cells, which can be maintained indefinitely and differentiated into any cell type of interest.

Introduction of DNA double - strand breaks by site - specific endonucleases called meganucleases is being successfully used to target endogenous genes in human cells.

These 45 variants are significantly enriched for protein - coding changes (n = 13), direct disruption of transcription - factor binding sites (n = 3), and tissue - specific epigenetic marks (n = 10), with the last category showing enrichment in specific immune cells among associations stronger in Crohn's disease and in gut mucosa among associations stronger in ulcerative colitis.

This provided the mechanism by which bacteria acquire immunity to specific viral infections, allowed introduction of specific mutations at desired sites, and provided the means to transfer efficient Cas9 - directed break, repair, and editing to any cell type.

Persistent inflammation induced by prolonged or repetitive exposure to specific allergens, typically characterized not only by the presence of large numbers of innate and adaptive immune cells (in the form of leukocytes) at the affected site but also by substantial changes in the extracellular matrix and alterations in the number, phenotype and function of structural cells in the affected tissues.

Cancer cells can spread tо mаnу ԁіffеrеnt parts оf tһe body, tһoυgһ thе mоѕt common sites are thе lungs, liver, brain, anԁ bones, аnd еach kind оf cancer tends tо spread tо specific sites.

In the opposite situation, when a healthy immune system reacts to environmental factors through cytokine production, PRPs send signals via specific cell receptor sites to decrease the production of cytokines in order to balance the immune system.

receptor sites: molecules on the surface of the body's cells that allow specific hormones to pass into the cell (via a lock - and - key effect) to perform their regulatory function.

Each antigen has a specific site where binds to the blood cells.

Special areas of interest include the interaction of gases and airborne particles to produce cellular and structural changes within site - specific regions and cells of the respiratory tract in both acute and chronic timeframes of exposure.

The site - specific installations are located in the two - story New Industries Building where «privileged» inmates were permitted to work; the Hospital main ward and psychiatric observation cells; A Block, the only cellblock not remodeled since the military prison was constructed in the early 20th century; and the Dining Hall.

In our latest employment - specific round - up, we highlight some of the notable jobs posted in big sister site Gamasutra's industry - leading game jobs section this week, including positions from 5th Cell, Insomniac and more.

For the opening reception, Hazelip will be occupying a replicated site - specific jail cell made of plexiglass that will be built to the size of a solitary confinement unit (six by nine feet).

[nggallery id = 16 template =» galleryview»] Among Morrison's recent works is Release, a site - specific installation relating to the 80th anniversary of Al Capone's release that has been up in a cell at the historical Eastern State Penitentiary in Philadelphia since March (it closes on November 30, 2010).

Popular Screen Sizes is a site - specific installation consisting of fourteen mirrors that range in size from a large television monitor down to a cell phone.

A fortnight later, the prescient Chilean artist Alfredo Jaar unveiled his new site - specific installation, The Garden of Good and Evil, in the Yorkshire Dales: a grid of 101 trees, sheltering nine steel cells no larger than two cubic metres.

The site - specific eight channel sound installation paired bird twitters to cell phone songs.

Using biology as a starting point for the study of boundaries and fragmentation in the human body, Joana Ricou presents in this, her first solo exhibit in Portugal, the series Multitudes (painting and works on wood and paper), paintings from the series Henrietta Lacks or HeLa cells searching, and the site - specific installation 60 kilos of Human Being (Oxygen, hydrogen, nitrogen, carbon, calcium and sulfur).

Acting head of Immigrations and Customs Enforcement Thomas Homan told Sen. Ron Wyden the agency does not use cell - site simulators — a type of surveillance gear often referred to as a «Stingray» that can track down a specific mobile device by emulating cell phone towers — to locate undocumented immigrants.

How do I handle requests for such references?Thank you so much for your help!CherylCHERYL M. EARLE3407 Old Dobbin Road, Montgomery, Alabama 36116 - 1903Home Phone: [phone] Cell Phone: [phone] Fax: [phone] E-mail: [email protected] position managing legal discovery and document review with opportunity to assist attorneys with civil litigationBAR ADMISSIONAlabama State Bar, 1999LAW - RELATED EXPERIENCELaw Firm, AlabamaResearch Attorney for Special Projects, Mass Torts Department, November 2001 — February 2008 • Managed Multi-District Litigation (MDL) Document Depository (September 2002 to February 2008) o Reviewed more than 1 million pages of evidentiary documents for litigation purposes and for inclusion in electronic databaseso Coordinated document review assignments with attorneys at local depository and at other sites across the USo Retrieved, reviewed and coded documents in Concordance and Summation legal databaseso Prepared memoranda and spreadsheets providing detailed analysis of discovery materials • Aided attorneys and support staff with processing and preparation of personal injury claims and litigationo Conducted legal research and drafted pleadingso Conducted supplementary online research for additional documents and information pertinent to litigationo Assisted with preparation of correspondence to clients and referring attorneyso Contacted clients for additional information needed in case preparation, litigation, and potential settlementso Prepared and input case intakes and referrals into databaseLaw School, AlabamaStudent Intern, Alabama Disabilities Advocacy Program (ADAP), August 1996 — June 1997 • Participated in law school clinical program under third - year law student practice rule (as authorized by Alabama Supreme Court) o Assisted attorneys and advocates in cases involving mentally ill patients confined to state mental health facilitieso Interviewed clients in person (at state facilities) and over the phoneo Worked with clients, attorneys, and social workers to investigate and resolve issues concerning involuntary confinement and treatmento Aided in legal research on an appellate brief submitted to the U. S. Court of Appeals for the Eleventh Circuit (ruling granted in favor of our client) Faculty Research Assistant for Library Services, Bounds Law Library, March 1996 — June 1997 • Prepared research and teaching materials for law school faculty; worked 20 hours per week while matriculating 10 - 15 hours per semester) o Investigated copyright issues related to procuring and reproducing texts for academic useo Conducted legal research using WESTLAW, LEXIS and the InternetADDITIONAL RELEVANT EXPERIENCEManufacturing Company (MC), Montgomery, AlabamaAdministrative Assistant and Cost Analyst, Materials Purchasing Department, April 1999 — September 2001 • Assisted materials buyers in negotiating and preparing commodities contracts between raw materials suppliers and MC for manufacturing plants in the US and Mexicoo Assisted Legal Department at MC's corporate headquarters with coordination and preparation of documents for litigationo Notified and educated suppliers about MC's freight - on - board policy and its corresponding Uniform Commercial Code (UCC) provisions; result was the reduction of freight claims for both the company and its supplierso Prepared contracts and purchase orders for raw materials and capital projects involving plant maintenanceo Solicited price quotations from current vendors and established Excel spreadsheet format which simplified quote submission process and allowed MC to track and compare usage volumes and costs over timeo Prepared and analyzed cost reports used by materials buyers and production planners in purchasing decisions, including cost reductions, materials consolidation, and selection of vendorso Acted as liaison between vendors and the Purchasing, Transportation and Accounting Departments on issues concerning inbound freight, commercial carriers, and payment terms for commodities, resulting in reductions in freight costs and greater payment discounts for raw materialso Established online databases and printed directories for the Purchasing Department, allowing buyers to have easier and faster access to current vendor informationo Completed Year 2000 (Y2K) compliance project, which involved data collection and communication with MC's past, present, and potential materials suppliers and service providersNot - For - Profit Organization, AlabamaAdministrative Assistant, Combined Federal Campaign, September 1998 — January 1999 • Aided Campaign Director with 1998 Federal Campaigns (CFCs) in City 1 and City 2, which together generated nearly $ 700,000 for more than 1,000 local, national and international charitieso Prepared weekly reports on donations using WordPerfect, Microsoft Word, Excel and dBase IVo Wrote script for Talent Showcase at City 1's 1998 CFC Kickoffo Assisted Director with merger of the City 1 and City 2 CFCs in 1999Regional Bank, AlabamaAdministrative Assistant, Year 2000 (Y2K) Department, March — June 1998 • Worked with Vice President of Corporate Projects on short - term project for the bank's Y2K Departmento Analyzed and processed data on Y2K readiness for all branches of Bank throughout the southeastern USo Organized meetings for personnel of Banko Communicated with vendors of computer hardware, software, and office equipment to request information on Y2K complianceo Prepared compliance files for Federal Reserve auditso Prepared in - house memoranda and reports using Microsoft Word and ExcelRecord / Music Promotion Company, AlabamaRecord Pool Co-Founder; Office Manager, September 1990 — December 1991 • Co-founded record pool to enhance promotion of music in Alabama and the southeastern USo Procured and distributed records from major and independent labels for club, radio and mobile disc jockeyso Coordinated jointly sponsored promotional events with record companies, radio stations and clubso Designed, wrote, and published bi-weekly reports and brochures to inform the music industry of the progress and popularity of music and performers in the region, with specific focus on the Alabama music sceneMajor University, AlabamaGraduate Research Assistant, AUM Department of Marketing, June 1989 — August 1990 • Worked 13 - 20 hours per week as a research assistant to Marketing faculty while carrying a full course load in the MBA programo Analyzed consumer surveys used in academic researcho Assisted Conference Chairperson with coordination for Atlantic Marketing Association (AMA) annual meeting (October 1989) o Co-authored five - year index and classification of AMA Proceedings (published Fall 1991) EDUCATIONLaw School, AlabamaJuris Doctor (JD), 1997 • Scholarshipso Seybourn H. Lynne Scholarship, 1996 - 97o Dexter C. Hobbs Memorial Scholarship, 1995 - 96o E. W. Godbey Memorial Scholarship, 1994 - 95 • Honorso Who's Who Among American Law School Students, 1996 - 94o Arthur Davis Shores Award, 1997 • Activitieso Frederick Douglass Moot Court Team Manager, 1996 - 97 Southern Regional Competition, Second Place National Competition, Eighth Placeo John A. Campbell Moot Court Competition, Spring 1996o Black Law Students Association Delegate, BLSA National Convention, 1997 Co-Chairperson, Public Relations Committee, 1996 - 97 Chairperson, Public Relations Committee, 1995 - 96 BLSA President's Award, 1996 and 1997o American Bar Association, 1996 - 97 Entertainment and Sports Industries Forum Intellectual Property Section Law Student Divisiono LAWS Student Group Leader, 1995 - 96Major University, AlabamaMaster of Business Administration (MBA), 1990Bachelor of Science in Business Administration (B.S.B.A.), 1988 (Major: Marketing — Advertising and Promotion Track) • Honorso Dean's List • Activitieso National Student Advertising Competition Team, 1988 - 90 Seventh District Competition: Third Place, 1990o Marketing Club, 1987 - 90 Vice President — Career Development, 1988 - 89o Public Relations / Advertising (PR / AD) Club, 1988 - 90 Charter Member, 1988 Active in fund - raising and membership driveso Theater Guild, 1988 - 90 Screening Committee, 1989REFERENCESAvailable upon request