Sentences with phrase «specific cell surface»

An inherent problem with this approach is that the presence of specific cell surface markers does not directly reflect the transcriptional state of a cell.

These capacities are more prevalent in cancer cells that feature a specific cell surface protein called CD44, Tang said.

By means of a non-obese diabetic / severe combined immunodeficiency disease (NOD / SCID) xenotransplant assay in combination with specific cell surface markers (CD44 + CD24 - / low), CSCs were enriched from metastatic and primary breast tumors and were shown to have the ability to reestablish tumor heterogeneity after transplantation [1].

Significantly, cells with reduced mtDNA became self - renewing and expressed specific cell surface markers characteristic of breast cancer stem cells.

Not exact matches

It then travels down the respiratory tract and binds to epithelial cells lining the lung airways via specific molecules on the cell surface.

At the end of September, the European Commission approved a marketing application for Lutathera, a radioactive molecule that targets specific receptors found on the surface of neuroendocrine tumor cells.

Advances include development of routes and surfaces that are more wheelchair and walker friendly; signage that includes Braille text and other tactile information to describe specific points of ecological interest; and trail «tours» that can be experienced through cell phones and other smart devices.

According to the American Pregnancy Association, the Rh factor is a specific type of protein on the surface of red blood cells.

To target liposomes to certain tissues or cells, such as tumour cells, a specific binder of a unique protein (an antigen) on the targeted cell, known as a monoclonal antibody, must be linked to the liposome surface.

After 24 days the cells had developed surface proteins that identified them as specific types of lung cell, including alveolar cells, which allow the exchange of gases, and cilia, which expel bacteria and dirt (Respiratory Research, DOI: 10.1186 / 1465-9921-10-105).

In another study, Rezende helped functionally characterize the specific fragments of the cell surface protein, Als5p, that allows the pathogenic fungus, Candida albicans, to bind to its host.

In their study, which has just been published in the journal PNAS, the researchers demonstrate that the defence protein docks on to a specific target in the nematode: a modified sugar found on the surfaces of the worm's intestinal cells but also on those of molluscs like snails.

This drug (vedolizumab) blocks a specific adhesion molecule on the surface of the T - cell and thereby inhibits immune cells from binding themselves to receptors present in the intestine, preventing the T - cells from penetrating the blood vessels in the intestinal tissue.

The fungal toxin binds to specific sugar structures which occur on the surface of intestinal cells of the nematode Caenorhabditis elegans.

The team found that after exposure to chemotherapy, the cells began developing physical markings usually seen in CSCs, including receptors on the cell surface to which specific proteins can bind.

Several studies have used cell - surface markers — proteins found on the outer membranes of tumor cells — to identify glioblastoma stem cells; but the specific markers used have been controversial and can not reflect molecular processes going on within tumor cells.

Using this strategy, researchers can engineer specific cells to produce a surface receptor that binds to a chemical compound known as CNO, a derivative of clozapine.

Gilbert reports that her team has tested such a combination in people, and has seen cell - mediated immunity to the universal proteins, as well as antibodies to specific surface proteins.

Other researchers have already loaded hollow origami structures with drugs to target specific types of cancer cells, created DNA «robots» that walk across surfaces, and mimicked the shape of viruses.

Researchers at Georgetown University Medical Center recently discovered that these drugs also interact with specific proteins on the surfaces of nerve cells — which could also lead to increased pain when patients wake up.

Most cancer vaccines developed to date have been designed to recognize and attack a specific known molecule — such as a cell - surface receptor — that is likely to be found on cancerous cells in any patient with that type of tumor.

«The antibody binds to a specific protein, called CD44s, which is expressed on the surface of pancreatic cancer stem cells.

In their report published in Science Immunology they describe how expression of a specific molecule — complement C5a — is required to cause the immune cells called neutrophils to adhere to joint surfaces and migrate into the joint, a process known to set off the inflammatory cascade.

They have also isolated specific receptors on the surfaces of cancer cells that green tea compounds may interact with.

The researchers found that POSTN acted through a specific integrin receptor that was present on the surface of many BLBC cells.

A normal cell has chemical receptors on its surface that link up with specific molecules generated by the body and control the timing of such functions as eating and sleeping.

The use of cell surface markers to isolate specific cell populations is one common method for separating cells; however, isolating live cells based on their RNA expression is a powerful new way enabling the study of small cell niches in nongenetically modified animal models and human tissue.

Research groups in Munich, Essen, and Brussels have now detected a highly specific and exceptionally strong variant of this adhesion, in which the bacterial surface molecule HopQ binds itself to so - called «Carcinoembryonic Antigen - Related Cell Adhesion Molecules,» or CEACAMs for short, inside the stomach.

Researchers at Karolinska Institutet have identified cell surface markers specific for the very earliest stem cells in the human embryo.

Once they are engineered with antibodies that bind to specific receptors on the surface of targeted cells, these nanoparticles also can, in principle, become highly specific to the disease they are designed to treat.

They have screened combinations of antibodies that bind to specific proteins on the surface of the immature and mature stem cells and that can be used for flow cytometry, a common laboratory technique for sorting cells.

Current efforts are focused on identifying TB - specific surface proteins that are targeted by CD4 + and CD8 + T cells and testing them in their multi-organ computational model.

By varying properties such as charge, composition, and attached surface molecules, researchers can design nanoparticles to deliver medicine to specific body regions and cell types — and even to carry medicine into cells.

Since cancer cells bear very specific antigens on the surface, the corresponding antibodies bind to these molecules and thus inhibit tumor growth.

Each T - cell recognizes just one specific pattern on the cell's surface and there are thousands of different T - cells.

This could be done by attaching molecules to the surface of the bots that bind to specific receptors on the outside of certain types of cell.

A specific lung - targeting molecule is attached to the carrier's surface and the steriod, dexamethasone, an anti-inflammatory, is loaded into the nanogel, which then binds to lung endothelial cells lining the inside wall of the blood vessels where it rapidly delivers the drug.

T cells are collected from the patient's blood and genetically engineered to express cell - surface proteins called CARs, which recognize specific molecules found on the surface of cancer cells.

One of the immunotherapeutic approaches that has been explored thus far relies on the use of monoclonal antibodies that specifically target a protein present on the surface of prostate cancer cells called prostate specific membrane antigen (PSMA) to elicit an anti-tumor immune response and control the cancer.

They work by sticking to specific proteins found on the surface of cancer cells, flagging them up to be killed by the immune system.

For example, he's designing nanoparticles that bait specific immune system cells by displaying certain features on their surface; inside, the nanoparticles contain an antigen of a particular microbe.

The cancer cell marker that Johnson and her team identified was a specific change in protein glycosylation, that is, a unique pattern of sugars decorating a protein found on the cell surface.

Each well holds a specific antibody that will bind selectively to one type of cancer cell type, based on genetic markers on its surface.

CXCR4 cell surface and intracellular expression was detected by flow cytometry after co-staining with the N - terminal specific CXCR4 antibody 4G10 and the extracellular loop (ECL) specific antibody 12G5 whose epitope includes the CXCR4Δ18 deleted residues [42].

Receptors are proteins that are usually located on the external surface of the cell membrane; they provide specific recognition sites for messenger substances such as hormones, neurotransmitters and growth factors.

It is regulated by receptor proteins located at the surface of specific cells that form a layer around the future break point.

These effects can be seen as a general response to the primitive signal conveyed by NGF through its specific receptors on the cell surface.

Researchers from immune biology professor Annette Oxenius's group have now discovered what keeps NK cells from killing off their «colleagues from the other department» of the immune system: healthy CD8 + cells are able to detect the immune messenger substance type 1 interferon, which binds to specific receptors on the surface of these immune cells and thereby conceals their stress.

«But the desired cells often lack a readily accessible surface marker, or that marker is not specific enough, as is the case for cardiac muscle cells.

Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes adhesion molecules, a class of cell surface proteins that function in the interactions of immune cells with other cells, including antigen - specific recognition and cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune disease.