Sentences with phrase «specific cell surface proteins»

These capacities are more prevalent in cancer cells that feature a specific cell surface protein called CD44, Tang said.

Not exact matches

According to the American Pregnancy Association, the Rh factor is a specific type of protein on the surface of red blood cells.

To target liposomes to certain tissues or cells, such as tumour cells, a specific binder of a unique protein (an antigen) on the targeted cell, known as a monoclonal antibody, must be linked to the liposome surface.

After 24 days the cells had developed surface proteins that identified them as specific types of lung cell, including alveolar cells, which allow the exchange of gases, and cilia, which expel bacteria and dirt (Respiratory Research, DOI: 10.1186 / 1465-9921-10-105).

In another study, Rezende helped functionally characterize the specific fragments of the cell surface protein, Als5p, that allows the pathogenic fungus, Candida albicans, to bind to its host.

In their study, which has just been published in the journal PNAS, the researchers demonstrate that the defence protein docks on to a specific target in the nematode: a modified sugar found on the surfaces of the worm's intestinal cells but also on those of molluscs like snails.

The team found that after exposure to chemotherapy, the cells began developing physical markings usually seen in CSCs, including receptors on the cell surface to which specific proteins can bind.

Several studies have used cell - surface markers — proteins found on the outer membranes of tumor cells — to identify glioblastoma stem cells; but the specific markers used have been controversial and can not reflect molecular processes going on within tumor cells.

Gilbert reports that her team has tested such a combination in people, and has seen cell - mediated immunity to the universal proteins, as well as antibodies to specific surface proteins.

Researchers at Georgetown University Medical Center recently discovered that these drugs also interact with specific proteins on the surfaces of nerve cells — which could also lead to increased pain when patients wake up.

«The antibody binds to a specific protein, called CD44s, which is expressed on the surface of pancreatic cancer stem cells.

They have screened combinations of antibodies that bind to specific proteins on the surface of the immature and mature stem cells and that can be used for flow cytometry, a common laboratory technique for sorting cells.

Current efforts are focused on identifying TB - specific surface proteins that are targeted by CD4 + and CD8 + T cells and testing them in their multi-organ computational model.

T cells are collected from the patient's blood and genetically engineered to express cell - surface proteins called CARs, which recognize specific molecules found on the surface of cancer cells.

One of the immunotherapeutic approaches that has been explored thus far relies on the use of monoclonal antibodies that specifically target a protein present on the surface of prostate cancer cells called prostate specific membrane antigen (PSMA) to elicit an anti-tumor immune response and control the cancer.

They work by sticking to specific proteins found on the surface of cancer cells, flagging them up to be killed by the immune system.

The cancer cell marker that Johnson and her team identified was a specific change in protein glycosylation, that is, a unique pattern of sugars decorating a protein found on the cell surface.

Receptors are proteins that are usually located on the external surface of the cell membrane; they provide specific recognition sites for messenger substances such as hormones, neurotransmitters and growth factors.

It is regulated by receptor proteins located at the surface of specific cells that form a layer around the future break point.

Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes adhesion molecules, a class of cell surface proteins that function in the interactions of immune cells with other cells, including antigen - specific recognition and cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune disease.

Finally, we have developed new techniques utilizing surface sensing of translation (SUnSET) and bioorthogonal noncanonical amino acid tagging (BONCAT) coupled with stable isotope labeling by amino acid in cell culture (SILAC) to selectively isolate and quantify newly synthesized proteins within specific temporal windows.

Our idea is to develop molecular structures (tiny machines) that would interact with specific proteins on the surfaces of these cells and stimulate them in response to light that enters the eye.

In fact, internalization of the prepared nanoparticles may depend on various factors, one being surface charge of nanoparticles, another one being the presence of specific receptors on cell surface and finally, it will also depend on the composition of the protein corona [30]- [32].

Intestinal permeability was assessed by Ussing chamber; epithelial cell (EC) ultra-structure by electron microscopy; RNA expression of genes coding for junctional proteins by Q - real - time PCR; immune response by in - vitro antigen - specific T - cell proliferation and cytokine analysis by cytometric bead array; intestinal microbiota by fluorescence in situ hybridization and analysis of systemic antibodies against intestinal microbiota by surface staining of live bacteria with serum followed by FACS analysis.

In the absence of the arginine protein, a lower number of T helper cells contained their surface receptors, as a specific protein chain which is part of the receptor complex requires an adequate amount of arginine molecules.